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  • 1
    ISSN: 1432-1173
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    HNO 48 (2000), S. 533-535 
    ISSN: 1433-0458
    Keywords: Schlüsselwörter Neurinome ; Nasenhaupthöhle ; Diagnostik und Therapie ; Key words Neurilemoma ; Nasal cavitiy ; Diagnosis and treatment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract A 35 years old male patient presented with serous nasal secretion, relapsing epistaxis and a slowly progredient nasal obstruction. Clinical examination and CT scans showed a tumor occupying the left middle meatus and the whole nasal cavity displosing the nasal septum to the right side. The tumor was resected by a midfacial degloving approach. Histological examination showed a neurinoma. By means of the presented case report and a review of literature, diagnosis and treatment of this rare nasal tumor are discussed.
    Notes: Zusammenfassung Die vorliegende Kasuistik beschreibt den Fall eines 35jährigen Patienten, der sich mit einer wässrigen Nasensekretion, rezidivierender Epistaxis und einer langsam progredienten, linksbetonten Nasenatmungsbehinderung in der HNO-Abteilung des BwK Ulm zur Abklärung vorstellte. Die klinische Untersuchung sowie das CT der Nasennebenhöhlen zeigten einen Tumor, der die komplette linke Nasenhaupthöhle ausfüllte und offenbar vom mittleren Nasengang ausging. Der Tumor wurde über ein Midfacial degloving in toto reseziert. Die histologische Aufarbeitung ergab die Diagnose eines Neurinoms. Anhand dieser Kasuistik und einer Übersicht über die Literatur wird die Diagnostik und die Therapie dieses seltenen Nasentumors dargestellt.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-0533
    Keywords: Key words Human brain ; Hippocampus ; Alzheimer’s disease ; Chromogranin B ; Synapse loss
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Synapse loss is crucially involved in cognitive decline in Alzheimer’s disease (AD). This study was performed to investigate the distribution and density of chromogranin B-like immunoreactivity in the hippocampus of control compared to AD brain. Chromogranin B is a large precursor molecule found in large dense-core vesicles. For immunocytochemistry we used an antiserum raised against a synthetic peptide (PE-11) present in the chromogranin B molecule. Chromogranin B-like immunoreactivity was concentrated in the terminal field of mossy fibers, the inner molecular layer of the dentate gyrus and in layer II of the entorhinal cortex. In AD, chromogranin B was detected in neuritic plaques. The density of chromogranin B-like immunoreactivity was significantly reduced in the inner molecular layer of the dentate gyrus and in layers II, III and V of the entorhinal cortex in AD brains. The present study demonstrates that chromogranin B is a marker for human hippocampal pathways. It is particularly suitable for studying nerve fibers terminating at the inner molecular layer of the dentate gyrus. It is present in neuritic plaques, and its density is reduced in a layer-specific manner.
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  • 4
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary Background The thickness of the sunscreen layer that is actually applied by consumers under usual conditions has been determined for photoprotective lotions and creams; however, this question is still unanswered for photoprotective lipsticks. Objectives To assess lipstick thickness (area density) and frequency of application per day for two commercially available photoprotective lipsticks with different consistency. Methods The study consisted of a laboratory test and a field experiment. In the laboratory test the applied lipstick thickness was determined as area density in mg cm−2 for a group of 28 panellists under standardized conditions. In a separate group of 18 subjects we assessed the area density and the frequency of application per day for two photoprotective lipsticks during a 6-day skiing course. Results In the laboratory test the median and 95% confidence interval of the area density was 0·98 mg cm−2 (0·66–1·65) and 0·86 mg cm−2 (0·63–1·40) for products A and B, respectively. The respective values of the field experiment were 1·58 mg cm−2 (0·79–2·23) (product A) and 1·76 mg cm−2 (1·16–3·50) (product B). Only 11% of all applications of lipstick A and 6% of all applications of lipstick B reached the reference area density of 2·0 mg cm−2. The difference between the median of the area density for lipstick A (firm consistency) and lipstick B (soft consistency) was not statistically significant. No statistically significant influence on the area density was found for age, sex, photobiological skin type or regular lipstick use. The median daily frequency of application was 2·2 times for lipstick A and 3·0 times for lipstick B. Conclusions Our investigation shows that photoprotective lipsticks are applied in a much thinner layer than recommended by international standards (2 mg cm−2). This results in a significant reduction of the photoprotective capacity. Furthermore, the frequency of application is too low for adequate protection. Therefore, we propose that the sun protection factor (SPF) should be assessed for an area density that reflects the actual usage patterns. As long as the test protocol is not adapted to the reduced area density, photoprotective lipsticks with high and ultrahigh SPF should be recommended, especially for individuals with increased risk for the development of lip malignancies.
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  • 5
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: At the new Munich high flux reactor FRM-II, the Munich Accelerator for Fission Fragments (MAFF) is under development. The main objective will be the production and study of new very heavy elements (Z〉100). To obtain this goal, intense beams of neutron rich isotopes (70〈A〈160) are required. Thermal neutron induced fission is considered the most suitable method to produce these isotopes due to the large fission cross section and high thermal neutron flux (〉1014 n/s*cm2) available at the new reactor. The target ion source design is based on the ANUBIS source at OSIRIS in Studvik, optimized for very high neutron fluxes. Using 1 g of 235U diluted in a graphite target, intensities of several 1011 ions/s for 91Kr, 132Sn, or 144Cs, e.g., are expected after mass separation. These singly charged ions will be charge bred in an electron cyclotron resonance ion source and then injected into the MAFF-LINAC to reach the energies at the Coulomb barrier. The production of intense ion beams of neutron rich isotopes by thermal neutron induced fission, the development of the target ion source, and the development of the fission target will be presented. © 2002 American Institute of Physics.
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  • 7
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 113 (2000), S. 876-882 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Spectral diffusion (SD) in polymethylmethacrylate (PMMA) doped with free-base tetraphenylporphine is investigated at 0.5–4.2 K on a time scale of 3–106 s via optical hole burning. Two contradictory results—within the framework of the two level system (TLS) model—are obtained. The first one is the absence of aging effects at temperatures near 4 K which puts the upper limit for the TLS relaxation times at tens of minutes. The second one is an intensive superlogarithmic SD on the whole time scale of the experiment, which is evidence for the presence of very slow relaxations, independent of the sample history on a time scale of up to two months. The results presented provide clear evidence of a deviation of SD behavior from the TLS model predictions at moderately low temperatures. The concept of structural relaxations is applied for a qualitative interpretation of the experimental data. © 2000 American Institute of Physics.
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  • 8
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Cytokeratin expression and epithelial differentiation in Warthin’s tumour and its metaplastic (infarcted) variant Aims: Warthin’s tumour is characterized by a bilayered columnar epithelium. Transformation into metaplastic (infarcted) Warthin’s tumour includes squamous metaplasia of the epithelium along with regressive changes in the stroma. Misinterpretation of metaplastic Warthin’s tumour for malignancy is a serious diagnostic pitfall. This study assesses the utility of cytokeratin expression in Warthin’s tumour and its metaplastic variant. Methods and results: Twenty-six cases of Warthin’s tumour, among them eight metaplastic Warthin’s tumours, were investigated employing immunohistochemistry. Both Warthin’s tumour and its metaplastic variant regularly expressed cytokeratins (CK) 7, 8, 18, and 19. Staining results with antibodies to CK10, 10/13, 1/2/10/11, and 20 were negative in all specimens. Immunoreactivity for CK 5/14 and 17 was restricted to basal cells in Warthin’s tumour, but involved basal as well as surface cells in metaplastic Warthin’s tumour. Conclusions: Warthin’s tumour and its metaplastic (infarcted) variant both express CK 7, 8, 18, and 19, which are typical for columnar differentiation. Cytokeratins typical of squamous differentiation are absent from Warthin’s tumour and its metaplastic variant, irrespective of the squamous morphology of the epithelium in metaplastic Warthin’s tumour. The expression of CK 5/14 and 17, which are typical of regenerative cells, is restricted to basal cells in Warthin’s tumour, but is expressed also in surface cells in metaplastic Warthin’s tumour.
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  • 9
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background  Thaumetopoea processionea L. (order Lepidoptera), the oak processionary moth, is found in oak forests in most European countries. Its third to sixth larval instars are armed with poisonous hairs (setae) containing an urticating toxin (thaumetopoein) potentially harmful to humans. Because T. processionea infests trees at the edges of forests or standing alone people frequently come into contact with its setae. In the woodland bordering on the western suburbs of Vienna conditions favouring its increase have led to frequent outbreaks of lepidopterism.Objectives  To determine the incidence of lepidopterism in a suburban environment with three separate caterpillar-infested oak trees and to ascertain the frequency of the various symptoms of lepidopterism and the manner of contact with setae.Methods  We conducted a telephone survey of all the households/institutions located within 500 m of the infested trees. To gain more information on patients' symptoms and on situations likely to lead to increased contact with setae we asked those who reported cutaneous reactions to complete a questionnaire. As part of the environmental study we described the outbreak site, examined patients and, with tape-strip samples taken from the surface of the soil, looked for setae persisting in the environment.Results  Of 1025 people surveyed 57 (5·6%) reported one or more symptoms of lepidopterism: 55 (96%) reported pruritus, 54 (95%) dermatitis, eight (14%) conjunctivitis, eight (14%) pharyngitis and two (4%) respiratory distress. The questionnaire was returned by 37 (69%) of the individuals with dermatitis. Of those, 16% had reacted with weal formation, 49% with papular rash and 22% with toxic irritant dermatitis. In 13% of respondents it was not possible to define the reaction. The risk factor analysis showed that airborne contamination was the most important cause: 97% of people had frequently passed an infested tree, 57% lived near a tree (in a neighbouring garden) and 32% had a tree in their own garden. Direct contact with larvae was of minor importance (38%). In four of the tape-strip samples intact setae were identified 1 year after the infestation.Conclusions  Lepidopterism caused by T. processionea is a public health problem of increasing significance. In years with outbreaks of the pest it can reach epidemic proportions in communities located near infested trees. Contact with airborne setae was mainly responsible for the occurrence of the disease.
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