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  • 1
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    German Medical Science; Düsseldorf, Köln
    In:  67. Jahrestagung der Deutschen Gesellschaft für Unfallchirurgie, 89. Tagung der Deutschen Gesellschaft für Orthopädie und Orthopädische Chirurgie und 44. Tagung des Berufsverbandes der Fachärzte für Orthopädie; 20031111-20031116; Berlin; DOC03dguA14-7 /20031111/
    Publication Date: 2003-11-11
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 2
    ISSN: 1432-1181
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract The natural circulation loop DANTON at the Dresden University of Technology was designed to investigate the thermohydraulic properties of integrated reactor concepts with a natural circulation driven primary loop. It is not possible to reach a stable two-phase flow in the loop without passing flow instabilities. At an equilibrium of heating and cooling power the flow oscillations can exist at nearly constant frequencies and amplitudes. The oscillating mass flow signal had been investigated by various methods: (a) autocorrelation function, (b) Fast Fourier transformation, (c) estimation of a temporal Liapunov-exponent and (d) reconstruction of the system attractor in a three-dimensional phase space. The selected time-series express a non-linear behaviour, however, they are not chaotic. In comparison to the usual methods the applied analysing methods yield additional information about system frequencies, sensitiveness to disturbances and properties due to non-linear and chaotic behaviour in a natural circulation loop.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1433-0431
    Keywords: Schlüsselwörter Kniegelenk • Individualendoprothetik • Computerunterstütztes Operieren • Kinematische Optimierung • Minimal-invasives Vorgehen ; Keywords Knee joint • Custom-made endoprosthesis • Computer-aided surgery • Kinematic optimization • Minimal invasive procedure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract A new method is presented which allows the construction and implantation of highly precise custom-made endoprostheses for knee joints. The procedure is based on a computer-aided subtraction process of three-dimensional CT data. Using the differences of the CT scans, the endprosthetic components are modelled by means of a newly developed software package. The implants are manufactured by CNC machines and stereolithography. The method enables the surgeon to reduce bone resections and ensures an exact profile of the bone-implant interface. Incorrect positioning will be avoided and the implantation process can be performed more easily while the size of the operative approach will be minimized. Better postoperative kinematics and reduction of shearing effects will lead to better results in the long run. The procedure offers a series of new possibilities to optimize monocondylar and bicondylar knee joint endoprostheses.
    Notes: Zusammenfassung Es wird ein neuartiges Verfahren vorgestellt, das die Fertigung und Implantation von hochexakten individuell geformten Oberflächenprothesen am Kniegelenk ermöglicht. Die Vorgehensweise basiert auf einem computergestützten Subtraktionsprozess von CT-Volumendaten. Aus den Differenzen wird das Implantat als dreidimensionales (3D-) Objekt rechnerisch modelliert und über einen sterolithografischen Zwischenschritt mittels CNC-Fräsung bzw. gusstechnisch hergestellt. Durch das Verfahren wird nicht nur eine möglichst geringe und den individuellen Gegebenheiten angepasste Knochenresektion ermöglicht, sondern auch eine optimale Kontaktfläche zwischen der Prothesenkomponente und dem Knochen gewährleistet. Positionierungsfehler werden reduziert, gleichzeitig wird der Implantationsvorgang erleichtert und die Größe des notwendigen Operationszugangs erheblich verringert. Durch die bessere Kinematik und die Reduktion der Scherkräfte ist nicht nur eine bessere Funktionalität sondern auch eine längere Haltbarkeit zu erwarten. Das Verfahren bietet mannigfaltige Optionen zur Verbesserung der herkömmlichen monokondylären und bikondylären Kniegelenksendoprothetik.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1434-6036
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract. We are interested in the thermal diffusion of a solitary wave in the anisotropic Heisenberg spin chain (HSC) with nearest-neighbor exchange interactions. The shape of the solitary wave is approximated by soliton solutions of the continuum HSC with on-site anisotropy, restricting ourselves to large width excitations. Temperature is simulated by white noise coupled to the system. The noise affects the shape and position of the solitary wave and produces magnons. Using implicit collective variables we describe the former effects and neglect magnons (i.e. we use the so-called adiabatic approximation). We derive stochastic equations of motion for the collective variables which we treat both analytically and numerically. Predictions for the mean values and the variances of the variables obtained from these equations are compared with the corresponding results from spin dynamics simulations. For the soliton position we find reasonable agreement between spin dynamics and the results of the collective variable treatment, whereas we observe deviations for the other collective variables. The stochastic dynamics of the position shows both a standard Brownian and a super-diffusive component. These results are analogous to results for the isotropic case, previously studied by some of the authors. In the present article we discuss in particular how the anisotropy enters the stochastic equations of motion and the quantitative changes it causes to the diffusion.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Oxford, UK : Munksgaard International Publishers
    Allergy 58 (2003), S. 0 
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1365-2826
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Sensitization of adenylate cyclase is a recently discovered phenomenon. Melatonin can induce a sensitized response of adenylate cyclase in ovine pars tuberalis cells where the receptor for melatonin is endogenously expressed. Although the mechanism is not fully understood, sensitization of adenylate cyclase may be an important part of the mechanism by which melatonin encodes daylength in the pars tuberalis of sheep and other animals. We used this as a hypothesis to search for a natural ligand that would activate adenylate cyclase in ovine pars tuberalis cells. The approach revealed pituitary adenylate cyclase activating polypeptide to be an indirect activator of adenylate cyclase in the ovine pars tuberalis. We discuss this in relation to the mechanism and importance of sensitization to the function to the pars tuberalis.
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  • 7
    Electronic Resource
    Electronic Resource
    Copenhagen : Munksgaard International Publishers
    Allergy 55 (2000), S. 0 
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-2072
    Keywords: Key words Opioids ; Self-administration ; Progressive ratio ; Drug abuse ; Human
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Rationale: Although most opioid self-administration research has been conducted with laboratory animals, such research with humans is necessary to answer questions unique to human drug-taking behavior. Objective: We investigated the influence of morphine dose and an alternative non-drug reinforcer on choice between morphine versus money and examined the relationship between drug-reinforced behavior and subjective euphoria. Methods: Five male opioid users participated in the 7-week study. During the first 5 weeks, a single dose of morphine (0, 4, 8, 16, or 32 mg/70 kg) was available each week. On Monday, subjects received an IM injection of the dose tested that week. On Tuesday, Thursday, and Friday, subjects could work for morphine or money under a second-order, progressive ratio schedule. For each primary ratio completed on the drug lever, subjects earned one-ninth of the available drug dose, and for each ratio completed on the money lever, subjects earned $1. Total amount of drug earned was administered in a single IM injection at the end of the session; money earned was credited to the subject’s account. Results: As morphine dose increased, responding for drug increased in an orderly manner and responding for money decreased. During the final phase of the study, the lowest and highest doses that maintained drug responding for each subject were repeated, and the value of the alternative reinforcer was increased to $2 per ratio. This manipulation was associated with decreased drug-maintained responding at the lowest, but not the highest, reinforcing dose of morphine. Conclusion: The progressive ratio, concurrent access procedure may be useful in predicting the outcome of drug abuse treatment interventions that use alternate reinforcement strategies.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1432-2072
    Keywords: Key words Sibutramine ; d-Amphetamine ; Abuse potential ; Subjective effect ; Human
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Rationale: Sibutramine (Meridia) is a serotonin and norepinephrine reuptake inhibitor marketed for weight control. Previous studies demonstrated low abuse potential for 20 and 30 mg sibutramine (doses near the therapeutic range); however, no data existed on supratherapeutic doses. This study, therefore, examined 25 and 75 mg sibutramine in humans compared to d-amphetamine (20 mg) as a positive control and placebo as a negative control. Objectives: The study examined the acute subjective, reinforcing, and physiological effects of sibutramine to assess its abuse liability. Methods: Twelve polydrug abusers with no history of drug dependence participated in this double-blind, inpatient/outpatient study. Volunteers participated in four drug sessions, in which they completed subjective effects scales including the Profile of Mood States (POMS), Visual Analog Scales (VAS), and the Addiction Research Center Inventory (ARCI). The Multiple Choice Procedure (MCP) was used to evaluate reinforcing efficacy. Results: Sibutramine 25 mg produced subjective effects that were indistinguishable from placebo. Sibutramine 75 mg produced significant unpleasant effects, such as Anxiety, Confusion, and decreased Vigor. On the MCP, volunteers chose to give up an average of $4.04 from their study pay rather than receive the higher dose of sibutramine again. In contrast, d-amphetamine 20 mg produced positive mood changes and was well liked. Conclusions: These data indicate sibutramine lacks amphetamine-type abuse liability when administered acutely.
    Type of Medium: Electronic Resource
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