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  • 1
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    German Medical Science; Düsseldorf, Köln
    In:  Evidenzbasierte Medizin - Anspruch und Wirklichkeit; 102. Jahrestagung der Deutschen Ophthalmologischen Gesellschaft; 20040923-20040926; Berlin; DOC04dogDO.01.03 /20040922/
    Publication Date: 2004-09-21
    Keywords: ddc: 610
    Language: English
    Type: conferenceObject
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  • 2
    ISSN: 1432-1173
    Keywords: Schlüsselwörter ; Herpes gestationis ; Schwangerschaftsdermatose ; Bullöses Pemphigoid ; BP180 ; Pruritus ; Key words ; Herpes gestationis ; Dermatoses of pregnancy ; Bullous pemphigoid ; BP180 ; Pruritus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Background and Objective: Pemphigoid gestationis (PG) is a rare pregnancy-associated autoimmune bullous disease characterized by autoantibodies to the 180 kD bullous pemphigoid antigen (BP180). The clinical spectrum of PG is polymorphic and for diagnostic purposes, a skin biopsy is usually taken demonstrating the deposition of autoantibodies. Patients and Methods: From 2 patients, skin biopsies were obtained for histopathologic and immunofluorescence studies. Circulating autoantibodies were characterized by immunoblotting and ELISA using a recombinant form of the immunodominant BP180 NC16 A domain. Results: The 2 PG patients described here did not show blisters but complained about severe itching. In the first case, PG presented in the first trimester of the second pregnancy as an erythema-multiforme-like disease. The second patient developed urticarial plaques a few days after delivery. PG was diagnosed by the detection of autoantibodies against recombinant BP180 NC16 A by immunoblot and ELISA analysis and confirmed by linear deposits of C3 at the cutaneous basement membrane zone on direct immunofluorecence microscopy. Skin lesions healed with oral prednisolon. Conclusions: In our two patients, non-bullous PG could be diagnosed by serological tests. Immunmoblotting and ELISA might be sensitive and specific tools when screening sera of patients with pruritic skin lesions in pregnancy for the presence of autoantibodies to BP180. In some cases, these newer techniques may make a skin biopsy unnecessary.
    Notes: Zusammenfassung Hintergrund und Fragestellung: Das Pemphigoid gestationis (PG) ist eine seltene, schwangerschaftsspezifische Autoimmundermatose mit Autoantikörpern gegen das 180 kD bullöse Pemphigoid Antigen (BP180). Das klinische Bild ist polymorph. Die Diagnose des PG wird meist anhand einer Biopsie mit Nachweis der Autoantikörper in der Haut der Patientinnen gesichert. Patienten/Methodik: Bei 2 Patientinnen wurden Hautbiopsien histopatholgisch und immunfluoreszenzoptisch untersucht. Die Autoantikörper wurden mittels Immunoblot und ELISA unter Verwendung einer rekombinanten Form der immundominanten BP180-NC16-A-Domäne charakterisiert. Ergebnisse: Bei den beiden vorgestellten Patientinnen verlief das PG ohne Blasenbildung, jedoch mit starkem Juckreiz. Bei unserer ersten Patientin manifestierte sich die Erkrankung im 1. Trimenon unter dem Bild eines Erythema multiforme, der 2. Fall trat wenige Tage postpartal unter dem Bild einer Urtikaria auf. Die Diagnose wurde jeweils durch den Nachweis von Antikörpern gegen rekombinantes BP180 NC16 A im Immunoblot und ELISA und durch lineare C3-Ablagerungen an der Basalmembran in der direkten Immunfluoreszenz gesichert. Die Hautveränderungen heilten bei beiden Patientinnen unter oraler Prednisolontherapie ab. Schlussfolgerung: Bei den beiden vorgestellten Patientinnen wurde anhand von Serumuntersuchungen ein PG ohne Blasenbildung diagnostiziert. Sowohl Immunoblot als auch ELISA erscheinen aufgrund ihrer hohen Sensitivität und Spezifität als Screeningverfahren zum Nachweis von Autoantikörpern gegen BP180 bei pruriginösen Schwangerschaftsdermatosen geeignet. In der Zukunft dürften sie mitunter die bisher unverzichtbare Hautbiopsie zur Diagnose eines PG ersetzen.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-055X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Munksgaard International Publishers
    Experimental dermatology 12 (2003), S. 0 
    ISSN: 1600-0625
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract. Virtual radiative corrections due to the long-range Coulomb forces of heavy nuclei with charge Z may lead to sizeable corrections to the Born cross-section usually used for lepton-nucleus scattering processes. An introduction and presentation of the most important issues of the eikonal approximation is given. We present calculations for forward electroproduction of rho-mesons in a framework suggested by the VDM (vector dominance model), using the eikonal approximation. It turns out that Coulomb corrections may become relatively large. Some minor errors in the literature are corrected.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Copenhagen : Munksgaard International Publishers
    Allergy 55 (2000), S. 0 
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1574-695X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Infections due to Klebsiella pneumoniae and other Klebsiella spp. are a leading cause of hospital-associated morbidity, especially in the intensive care setting. In this study, the hypothesis that normal human sera contain sufficient concentrations of K-antigen-specific antibodies to promote phagocytic killing of encapsulated, highly virulent Klebsiella organisms was tested. K2-antigen-specific IgG and IgM antibodies were detected in each of 10 normal sera, and such antibodies were functionally active in a phagocytic killing assay. Phagocytosis depended critically on sufficient numbers of neutrophils and was impaired by the presence of soluble Klebsiella capsular polysaccharide (CPS). Thus, insufficient numbers of neutrophils and circulation of soluble CPS but not lack of K-specific antibodies may be detrimental in Klebsiella sepsis. The efficacy of hyperimmune sera might be based not on enhancement of phagocytosis but on the neutralization of these detrimental effects of circulating CPS and LPS.
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  • 8
    ISSN: 1572-9540
    Keywords: resonance ionization mass spectrometry ; ultratrace analysis ; 41 calcium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract A compact resonance ionization mass spectrometer is presented. It is presently applied for sensitive and highly selective ultratrace determination of the long-lived radioisotope 41Ca for environmental, biological, and fundamental investigations. The development of coherent multistep resonance ionization enables the realization of experimental detection limits as low as106 atoms per sample and very high isotopic selectivity above 1012.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1434-6079
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract. Resonance ionization mass spectrometry (RIMS) has proven to be a powerful method for isotope selective ultra-trace analysis of long-lived radioisotopes. For plutonium detection limits of $\rm 10^{6}$ to $\rm 10^{7}$ atoms have been achieved for various types of samples. So far a three-step, three-color laser excitation scheme was applied for efficient ionization. In this work, a two-photon transition from an excited state into a high-lying autoionizing state, will be presented, yielding a similar overall efficiency as the three-step, three-color ionization scheme. In this way, only two tunable lasers are needed, while the advantages of a three-step, three-color excitation (high selectivity, good efficiency and low non-resonant background) are preserved. The two-photon transition has been characterized with respect to saturation behavior and line width. The three-step, two-color ionization is a possibility for an improved RIMS procedure.
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  • 10
    ISSN: 1572-9540
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Optical isotope shift measurements have been performed at the 244f Am fission isomers (T 1/2=1 ms) with low target production rates of 10/s employing resonance ionization spectroscopy in a buffer gas cell. The isotope shift ratio IS244f,241/IS243,241 = 42.0(9) has been measured at the 500.02 nm transition. A change in the nuclear mean charge radius $$\delta \langle r^2 \rangle _{{\text{opt}}}^{{\text{224}}f,241}$$ = 5.41(31) fm2 and an intrinsic quadrupole moment $$Q_{{\text{20}}}^{{\text{224}}f}$$ = 34.4 eb have been deduced with the deformed Fermi model. The small difference of the nuclear parameter Λ244f,242f = 0.069(21) fm2 between the 244f Am and 242f Am fission isomers results in a change of the quadrupole moment $$\delta Q_{{\text{20}}}^{{\text{224}}f,242f}$$ eb only and demonstrates the stability of the superdeformation in the second potential minimum if two neutrons are removed.
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