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  • 1
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Prodynorphin, the precursor of the dynorphin opioid peptides, has been shown to play an important role in several aspects of human diseases and complex traits, e.g., drug abuse, epilepsy, and mood disorders. The objective of this study was to identify polymorphisms in the 5′ control region of the human prodynorphin gene and to relate these polymorphisms to prodynorphin gene expression. Within the core promoter region, a 68-bp sequence was found to occur as a polymorphic element, either singular or as tandemly repeated element two, three, or four times. This 68-bp repeat element contains an AP-1 transcription factor binding site as demonstrated by electrophoretic mobility shift assay. Reporter gene assays were performed and provided evidence for allele dependent different promoter activity. Dynorphin was found to be involved in many pathophysiological processes so that the described prodynorphin alleles may correlate with the occurrence of several diseases, for example, drug addiction. However, prodynorphin allelic distributions were not significantly different in heroin addicts and control subjects.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 0044-281X
    Keywords: Schlüsselwörter Rehabilitationsforschung – geriatrische Rehabilitation – Rehabilitationserfolg – psychosoziale Aspekte ; Key words Rehabilitation research – geriatric rehabilitation – rehabilitation success – psychosocial aspects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary This study considers findings of psychological gerontology as particularly important for geriatric rehabilitation research. Its concrete aim was to describe the course and outcome of geriatric rehabilitation based on a wide range of success criteria, to explore the influencing role of age, sex, and diagnosis as well as to describe the variability pattern of success. The data were gathered from a sample of 100 older adults who underwent treatment in a German inpatient rehabilitation unit. Participants were assessed across five measurement occasions by use of a state-of-the-art geriatric assessment and psychological data collection part. The results underline, for one, that significant improvements of functional as well as psychological capacity were obtained. Second, age and sex played practically no role concerning the course of the success criteria, whereas diagnosis revealed some statistically meaningful effects. Third, it was found that the variability of success was characterized by a relatively homogenous pattern of gain with regard to functional criteria; with respect to psychological variables, heterogeneity was more pronounced and some participants show loss as well, a chance for further improvement of the geriatric rehabilitation.
    Notes: Zusammenfassung Diese Arbeit geht von der Notwendigkeit aus, grundlegende Erkenntnisse der psychologischen und sozialwissenschaftlichen Gerontologie stärker als bisher in die empirische Rehabilitationsforschung mit alten Menschen einzubeziehen. Konkretes Ziel war es, den kurz- und langfristigen Verlauf geriatrischer Rehabilitation mit Hilfe eines erweiterten Spektrums von Erfolgsmaßen zu beschreiben, den Einfluß der Variablen Alter, Geschlecht und Diagnose auf den Verlauf zu prüfen, sowie die interindividuelle Variabilität des Erfolges zu beschreiben. Dazu wurden 100 Patienten der stationären geriatrischen Rehabilitation über 5 Meßzeitpunkte hinweg einer eingehenden medizinisch-geriatrischen sowie psychologischen Erhebung unterzogen. Die Ergebnisse zeigen, daß die Rehabilitation sowohl kurz- als auch langfristig gute bis sehr gute Erfolge in geriatrisch-medizinischen und psychosozialen Aspekten der Lebensqualität erbringt. Das Lebensalter und das Geschlecht spielen nahezu keine Rolle im Hinblick auf den Verlauf der Erfolgsmaße, während sich deutliche Diagnoseeffekte nachweisen lassen. Hinsichtlich der Variabilität des Erfolges zeigen sich vergleichsweise homogene Verläufe in bezug auf die medizinisch-geriatrischen Erfolgsmaße mit deutlichen Erfolgen bei nahezu allen Teilnehmern. In bezug auf die psychosozialen Maße sind neben moderater ausfallenden Gewinne bei einigen Personen auch Verluste zu konstatieren, ein Hinweis, die Bemühungen in diesem Bereich zu verstärken.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] The dystonias are a common clinically and genetically heterogeneous group of movement disorders. More than ten loci for inherited forms of dystonia have been mapped, but only three mutated genes have been identified so far. These are DYT1, encoding torsin A and mutant in the early-onset generalized ...
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  • 4
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: Parabolic compound refractive lenses are high quality optical components for hard x rays. They are particularly suited for full field imaging, with applications in microscopy and x-ray lithography. Taking advantage of the large penetration depth of hard x rays, the interior of opaque samples can be imaged with submicrometer resolution. To obtain the three-dimensional structure of a sample, microscopy is combined with tomographic techniques. In a first hard x-ray lithography experiment, parabolic compound refractive lenses have been used to project the reduced image of a lithography mask onto a resist. Future developments are discussed. © 2002 American Institute of Physics.
    Type of Medium: Electronic Resource
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