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  • 1
    Call number: QV137:61/1(4) ; ZZ2003:2/1(4)/Mag
    Keywords: Tobacco Use Disorder ; Smoking Cessation ; Health Surveys ; DKFZ-publications
    Notes: Verantwortlich für den Inhalt: Deutsches Krebsforschungszentrum Stabsstelle Krebsprävention und WHO-Kollaborationszentrum für Tabakkontrolle.
    Pages: 24 + unnumbered p.
    Edition: 4., überarb. Aufl.
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    ZZ2003:2/1(4)/Mag departmental collection or stack – please contact the library
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  • 2
    Call number: ZZ2003:2/1/Mag
    Keywords: Tobacco Use Disorder ; Smoking Cessation ; Health Surveys ; DKFZ-publications
    Notes: Verantwortlich für den Inhalt: Deutsches Krebsforschungszentrum Stabsstelle Krebsprävention.
    Pages: 24 + unnumbered p.
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  • 3
    Call number: QV137:64(2)
    Keywords: Tobacco Use Disorder ; Smoking Cessation ; DKFZ-publications
    Notes: Im Rahmen des WHO-Partnerschaftsprojekts Tabakabhängigkeit ; in Zusammenarbeit mit dem Wissenschaftlichen Aktionskreis Tabakentwöhnung (WAT e.V.)
    Pages: 121 p.
    Edition: 2., überarbeitete Auflage: 1001 - 3000.
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  • 4
    ISSN: 1432-1041
    Keywords: Atrial natriuretic peptide ; Hypertension ; SCH 42354 ; blood pressure ; neutral metalloendopeptidase ; pharmacodynamics ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract SCH 42354, a neutral metalloendopeptidase (NEP) inhibitor, is the pharmacologically active form of the prodrug SCH 42495. It exerts antihypertensive effects by potentiating atrial natriuretic peptide (ANP) activity through inhibition of its hydrolysis by NEP. The objective of this study was to characterize the pharmacokinetics (PK) and pharmacodynamics (PD) of SCH 42354 in hypertensive males. SCH 42495 12.5 to 400 mg was administered orally to hypertensive men twice daily in a double-blind, placebo controlled multiple-dose parallel group design. Plasma SCH 42354 concentration and diastolic blood pressure (DBP) data were used to develop a PK-PD model using two approaches. In the first (non-integrated) approach, the “link” model was used to predict effect-site concentrations, and was applied to data obtained at the 300 and 400 mg BID doses only; data at the other (lower) doses were not amenable to modeling because of high variability. Effect-site concentration and DBP data were then fit to a sigmoid Emax PD model. For the 300 mg BID dose, PD parameters were: maximum effect (Emax), 8.1mmHg; no-drug effect (Eo), 3.6 mmHg; concentration corresponding to 50% of maximum response (EC50), 0.87 μg·ml−1; and gamma, 3.9. In the second (time-integrated) approach, plasma SCH 42354 concentration and effect data obtained over the entire dose range were integrated with respect to time. Average plasma concentration and DBP data were then fit to a simple Emax PD model. PD parameters obtained over the dose range were: Emax, 10.3 mmHg; Eo, 2.0 mmHg; and EC50, 0.7 μg·ml−1. These were similar to the estimates obtained from the first approach, demonstrating that the integrated (average) data allow PK-PD modeling over the (entire) dose range. The analysis showed that, at steady-state, a 400 mg BID dose of SCH 42495 produced an approximate 10 mmHg decrease in DBP in hypertensive males; the average plasma SCH 42354 concentration attained at this dose was approximately 1.8 μg·ml−1.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1433-0407
    Keywords: Schlüsselwörter EKT ; Elektrokrampftherapie ; Betreuungsgesetz ; Key words ECT ; Electroconvulsive therapy ; § 1904 German Civil Code
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary If patients who need electroconvulsive therapy are unable to consent, it is necessary to gain the guardian’s permission to carry out the treatment. It remains unclear if, due to possible side effects, it is necessary to gain an additional approval from the Guardianship Court according to § 1904 of German Civil Code (BGB). The high court of Hamburg (Landgericht Hamburg) decided that legal permission is necessary as a result of the risk of persisting retrograde amnesia and the ensuing danger of permanent damage to the patient’s health. This paper points out however, that electroconvulsive therapy, even considering the contraindications, is a safe and effective treatment for depression and schizophrenic psychoses. Application of unilateral short-pulse stimulation reduces the frequency and intensity of cognitive side effects. In particular, retrograde amnesia is very rare with regard to frequency and intensity and is negligible when compared with the dangers of the illness itself. There- fore, it is not necessary to apply for approval from the Guardianship Court.
    Notes: Zusammenfassung Besteht bei einwilligungsunfähigen Patienten die Indikation zur Durchführung einer Elektrokrampftherapie (EKT), ist die Genehmigung des Betreuers zur Durchführung der Heilbehandlung erforderlich. Unklar ist, ob aufgrund von eventuellen Nebenwirkungen zusätzlich eine vormundschaftsgerichtliche Genehmigungspflicht im Sinne des § 1904 BGB anzunehmen ist. Das Landgericht Hamburg war unter Verweis auf das Risiko persistierender retrograder Amnesien von der begründeten Gefahr eines länger dauernden gesundheitlichen Schadens ausgegangen und hatte die Genehmigungspflicht bejaht. Die Elektrokrampftherapie ist jedoch unter Beachtung der Kontraindikationen eine sichere und effektive Therapiemaßnahme zur Behandlung von Depressionen und schizophrenen Psychosen. Die Anwendung der unilateralen Kurzpulsstimulation reduziert die Häufigkeit und Ausprägung der kognitiven Nebenwirkungen. Insbesondere retrograde Amnesien treten nur sehr selten und in einer Ausprägung auf, die angesichts der Gefährdungen durch die Grunderkrankung zu vernachlässigen ist. Eine vormundschaftsgerichtliche Genehmigungspflicht im Rahmen des Betreuungsgesetzes ist nach Meinung der Autoren zu verneinen.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1420-9098
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
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  • 7
    ISSN: 1369-1600
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Indications of a genetic predisposition to nicotine dependence have been derived from numerous epidemiological data and from individual genetic studies suggesting the involvement of the dopaminergic D2 receptor. Previous association studies defined the TaqlA polymorphism as a risk factor for addiction, in particular for alcoholism and tobacco dependence. Results of investigations into this polymorphism in 110 severely addicted smokers and a control group of 60 population-matched German non-smokers did not support these findings. However, our results indicate an association between the DRD2-Fokl-1 allele and the onset and intensity of smoking.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Copenhagen, Denmark : Munksgaard International Publishers
    ISSN: 1399-3038
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Low vitamin A levels have been found in a number of diseases in children. The aim of this study was to examine the vitamin A status in children with asthma and to correlate the changes with severity of disease. Serum levels of vitamin A, retinol-binding protein (RBP), and albumin were estimated in 35 asthmatic children (24 males) in the age group of 2–12 years (mean 5.89 years) and 29 controls (19 males). Both study and control groups were similar with respect to age, sex, and overall nutritional status. Twenty-four children in the study group (68.6%) had moderate to severe persistent asthma and eight children had mild persistent asthma. Only three patients suffered from mild intermittent asthma. Vitamin A levels in children with asthma (mean ± SD 22.14 ± 5.38 µg/dl) were found to be significantly lower than their controls (mean ± SD 27.54 ± 4.83 µg/dl) (p = 0.0001). Age, age of onset of asthma, and gender had no correlation with serum vitamin A levels. Low serum vitamin A levels (〈 20 µg/dl) were observed four times more commonly in the study group (28.6%) than controls (6.9%). Severity of asthma had a negative correlation with serum vitamin A levels (r = − 0.61, p = 0.0001). Children with severe persistent asthma had markedly low serum vitamin A levels (mean ± SD 13.42 ± 5.19 µg/dl) as compared with mild intermittent asthma (mean ± SD 24.61 ± 2.32 µg/dl). Therapeutic trials are needed to prove whether low vitamin A levels contribute to asthma severity and the clinical utility of vitamin A supplementation in asthmatic children.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1432-0959
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract We study a class of problems involving the motion of a linear elastic body in frictional contact with a linear elastic half space. The dynamic effects considered are the inertial properties of the body regarded as rigid. We study only those regimes of contact interaction for which the slip velocity with the body taken as absolutely rigid and the time rate of change of the elastic displacements of points of the body and the half space that are on the contact surface are of the same order of magnitude. This work generalizes previous work on similar problems in that we simultaneously consider inertia forces of the body and the convective term in the slip-velocity due to the rigid-body velocity of the slider/indentor. Thus regimes of contact interaction investigated include rolling/sliding and shift-torsion type. We propose a variational formulation of the following two problems: (a) finite contact area and shift-torsion type of contact kinematics, (b) local contact area and general kinematics at the contact surface. Results for an elastic cylinder contacting an elastic half-plane are also given.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-0959
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract. We study a class of problems involving the motion of a linear elastic body in frictional contact with a linear elastic half space. The dynamic effects considered are the inertial properties of the body regarded as rigid. We study only those regimes of contact interaction for which the slip velocity with the body taken as absolutely rigid and the time rate of change of the elastic displacements of points of the body and the half space that are on the contact surface are of the same order of magnitude. This work generalizes previous work on similar problems in that we simultaneously consider inertia forces of the body and the convective term in the slip-velocity due to the rigid-body velocity of the slider/indentor. Thus regimes of contact interaction investigated include rolling/sliding and shift-torsion type. We propose a variational formulation of the following two problems: (a) finite contact area and shift-torsion type of contact kinematics, (b) local contact area and general kinematics at the contact surface. Results for an elastic cylinder contacting an elastic half-plane are also given.
    Type of Medium: Electronic Resource
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