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  • 1995-1999  (329)
  • 1960-1964  (129)
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  • 1
    ISSN: 1432-1246
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Die Autoren vollzogen an Kaninchen mit akuter Quecksilbervergiftung Untersuchungen des Eiweißspektrums, der Muco- und Lipoproteide Bowie der Aktivität der alkalischen Serumphosphatase. Gleichzeitig führten sie in vitro-Teste durch, um den Mechanismus zu klären, der zur Inaktivierung der Phosphatase führt. Die Ergebnisse zeigen, daß lösliche Quecksilbersalze, ix. injiziert, eine Verminderung des Gesamteiweißes verursachen, und zwar hauptsächlich der Albumine bei gleichzeitigem Anstieg der β-Globulin-Fraktion. Es wurde eine deutliche Hebung des Mucoproteidspiegels im Blutserum beobachtet. Das Lipoproteidbild des Serums zeigee eine charakteristische Abnahme der kleinmolekularen Fraktion α zugunsten der großmolekularen Fraktionen β and γ. Quecksilber-Ionen verursachen Aktivitätsabfall der alkalischen Phosphatase durch direkte Einwirkung auf das Enzym. Die Phosphataseaktivität verhält sich umgekehrt proportional zur Hg-Ionen Konzentration. Die Inaktivierung erfolgt wahrscheinlich durch Blockierung der Amino- und Carboxylgruppen des Enzymeiweißes.
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  • 2
    ISSN: 1433-0474
    Keywords: Schlüsselwörter Multiple Sklerose ; Insulinabhängiger Diabetes mellitus ; Key words Multiple sclerosis ; Insulin dependent diabetes mellitus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Insulin-dependent diabetes mellitus and multiple sclerosis are thought to stem from autoimmunological processes. We describe a 14 year old female adolescent, in whom both diseases manifested almost at the same time. Discussion: The etiology of both diseases is not yet clarified. However, in our case this tight temporal coincidence points to a preceeding virus infection as a common pathologic factor in addition to a genetic predisposition.
    Notes: Zusammenfassung Autoimmunologische Prozesse werden sowohl für die Entwicklung eines insulinabhängigen Diabetes mellitus als auch der Multiplen Sklerose verantwortlich gemacht. Wir berichten über das nahezu zeitgleiche Auftreten beider Erkrankungen bei einer 14jährigen Jugendlichen. Diskussion: Obwohl die Ätiopathogenese beider Erkrankungen bislang nicht geklärt ist, wies die zeitliche Korrelation infektiologischer und immunologischer Parameter in unserem Fall auf eine vorangegangene Virusinfektion bei entsprechender genetischer Prädisposition als gemeinsamen ätiologischen Faktor hin.
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Der Internist 40 (1999), S. 729-738 
    ISSN: 1432-1289
    Keywords: Schlüsselwörter Cor pulmonale ; Diagnostik ; pulmonale Hypertension ; Diagnostik
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zum Thema Es gibt relativ wenige Krankheitsbilder in der Inneren Medizin, bei denen Anamnese, Inspektion und klinische Untersuchung vergleichbar aussagekräftige Informationen und Befunde erbringen wie beim Vorliegen eines klinisch manifesten Cor pulmonale. Ziel der vorliegenden Arbeit ist, auf den klinischen Befunden aufbauend die apparativ gestützte Stufendiagnostik aufzuzeigen: Lungenfunktion, zunächst mit einfachen, danach mit speziellen Tests, Elektrokardiographie, Röntgenthorax, Echokardiographie mit den verschiedenen Methoden, Computertomographie, Magnetresonanztomographie, Radionuklidventrikulographie und schließlich Rechtsherzkatheter. Über die Indikationen zu diesen Untersuchungen und über die Validität der jeweiligen Methoden wird eingehend referiert. Hauptanliegen bei allen Untersuchungen ist natürlich eine besonders effektive Früherkennung der pulmonalen Hypertonie und der Ausbildung eines Cor pulmonale, um therapeutische Maßnahmen gezielter einleiten und deren Wirksamkeit besser überwachen zu können. Dies ist nicht zuletzt durch die epidemiologischen Daten des Cor pulmonale (vgl. dazu die Arbeit von M. Orth et al. in diesem Heft) gerechtfertigt, das neben der hypertensiven und koronaren Herzkrankheit bei Patienten über 50 Jahren die häufigste Herzerkrankung ist.
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  • 4
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Haemophilus influenzae type b is an encapsulated bacterium that initiates infection by colonizing the upper respiratory epithelium. In vitro studies indicate that H. influenzae type b is capable of expressing two morphologically distinct filamentous adhesive structures, referred to as pili and fibrils, respectively. In this study, we examined adherence to a variety of human epithelial-cell types and demonstrated that pili and fibrils have separate cellular binding specificities. In addition, we found that capsular material inhibits fibril recognition of the host-cell surface. This inhibitory effect was reduced when bacteria were grown to stationary phase, reflecting diminished encapsulation. However, when growth medium was supplemented with Mg2+, stationary-phase organisms were relatively heavily encapsulated and non-adherent. These observations suggest that encapsulation can be modulated in response to growth phase or environmental signals. It is possible that encapsulation is down-modulated early in the infectious process in order to avoid interfering with colonization. In contrast, encapsulation may be up-modulated between hosts and during bacteremia, where it appears to confer a selective advantage. We speculate that this model may also apply to other encapsulated pathogens.
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  • 5
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: The N gene product of coliphage λ, with a number of host proteins (Nus factors), regulates phage gene expression by modifying RNA polymerase to a form that overrides transcription-termination signals. Mutations in host nus genes diminish this N-mediated antitermination. Here, we report the isolation and characterization of the rpoAD305E mutation, a single amino acid change in the carboxy terminal domain (CTD) of the α subunit of RNA polymerase, that enhances N-mediated antitermination. A deletion of the 3′ terminus of rpoA, resulting in the expression of an α subunit missing the CTD, also enhances N-mediated antitermination and, similar to rpoAD305E, suppresses the effect of nus mutations. Thus, the N–Nus complex may be affected through contacts with the CTD of the α subunit of RNA polymerase, as is a group of regulatory proteins that influences initiation of transcription. What distinguishes our findings on the N–Nus complex from those of previous studies with transcription proteins is that all of the regulators characterized in those studies bind DNA and influence transcription initiation; whereas the N–Nus complex binds RNA and affects transcription elongation. A screen of some previously identified rpoA mutations that influence transcription activators revealed only one other amino acid change, L290H, in the CTD of the α subunit, that influences antitermination. Although our results provide evidence that interactions of the α subunit of RNA polymerase must be considered in forming models of transcription antitermination, they do not provide information as to whether the interactions of α that ultimately influence antitermination occur during initiation or during elongation of transcription.
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  • 6
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Hemophilus influenzae type b is a Gram-negative bacillus that initiates infection by colonizing the upper respiratory tract. Previous studies have established that H. influenzae haemagglutinating pili possess adhesive properties and influence the process of colonization. Additional studies suggest the presence of a second H. influenzae adhesin distinct from haemagglulinating pili. In the present study, we examined a non-piliated H. influenzae type b strain by transmission electron microscopy and visualized occasional short, thin, surface fibrils. Subsequently, we isolated a spontaneous mutant that lacked surface fibrils and was deficient in adherence to cultured human epithelial cells. Using a cloning strategy that exploited this mutant, we isolated a fragment of DNA that promotes in vitro adherence to human epithelial cells when expressed in laboratory strains of Escherichia coli. Mutagenesis of this fragment in a series of H. influenzae type b strains resulted in loss of expression of surface fibrils and a marked decrease in attachment. Furthermore, restoration of surface fibril expression was associated with reacquisition of wild-type levels of adherence. Our results are consistent with the conclusion that H. influenzae type b surface fibrils have adhesive capacity. We speculate that these organelles facilitate colonization of the human respiratory tract.
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  • 7
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
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  • 8
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
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  • 9
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Human genetics 〈Berlin〉 1 (1964), S. 14-23 
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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