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  • 1
    ISSN: 1432-0568
    Keywords: Key words Mechano-receptors ; Palate ; Merkel cell ; Ruffini corpuscle ; Free nerve ending ; Lamellated corpuscle ; Meissner corpuscle
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The sensory innervation of the hard palate of the rhesus monkey was studied by light and electron microscopy. The mucosa of the hard palate is subject to a particularly heavy mechanical load requiring functional specialisation of the horny epithelium in the form of thickenings – the papilla incisiva and eight pairs of rugae palatinae. A thin layer of firm connective tissue (lamina propria) attaches the mucosa to the periost of the hard palate. Sensory nerve fibres were found most abundantly in the papilla incisiva and first rugae palatinae. Their number decreases in an aboral direction. Five types of sensory nerve endings were found. Free nerve endings were ubiquitous in the epithelium and lamina propria. Merkel nerve endings were found in the basal layer of the epithelium of the papilla incisiva and rugae palatinae. Meissner corpuscles were located in the connective tissue between epithelial pegs, while lamellated corpuscles were seen below the epithelial pegs. Ruffini corpuscles were found in the deeper layer of the lamina propria. Thus, a variety of sensory nerve endings were found in the hard palate, especially in those areas that are in close contact with the tongue during chewing of food. This rich innervation suggests an important role in monitoring the mechanical properties of food and the position of the tongue.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1573-7276
    Keywords: bone metastasis ; cell line ; demethylation ; estrogen receptor ; human breast cancer ; vimentin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The LCC15-MB cell line was established from a femoral bone metastasis that arose in a 29-year-old woman initially diagnosed with an infiltrating ductal mammary adenocarcinoma. The tumor had a relatively high (8%) S-phase fraction and 1/23 positive lymph nodes (LN). Both the primary tumor and LN metastasis were positive for estrogen receptor (ER) and progesterone receptor (PgR), but lacked erbB2 expression. Approximately one year later, the patient presented with a 0.8 cm comedo-type intraductal mammary adenocarcinoma in the left breast that was negative for ER and PgR, but positive for erbB2. Thirty-five months after the initial diagnosis she was treated for acute skeletal metastasis, and stabilized with a hip replacement. At this time, tumor cells were removed from surplus involved bone, inoculated into cell culture, and developed into the LCC15-MB cell line. The bone metastasis was a poorly differentiated adenocarcinoma lacking ER, PgR, and erbB2, characteristics shared by the LCC15-MB cells, although ER can be re-expressed by treatment of the LCC15-MB cells for 5 days with 75 μM 5-aza-2′-deoxycytidine. The LCC15-MB cell line is tumorigenic when implanted subcutaneously in NCr nu/nu mice and produces long-bone metastases after intracardiac injection. Although the bone metastasis from which the LCC15-MB cell line was derived lacked vimentin (VIM) expression, the original primary tumor and lymph node metastasis were strongly VIM positive, as are LCC15-MB cells in vitro and in nude mice. The karyotype and isozyme profiles of LCC15-MB cells are consistent with its origin from a human female, with most chromosome counts in the hypertriploid range. Thirty-two marker chromosomes are present. These cells provide an in vitro/in vivo model in which to study the inter-relationships between ER, VIM, and bone metastasis in human breast cancer.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Letters in mathematical physics 41 (1997), S. 135-147 
    ISSN: 1573-0530
    Keywords: Wightman theory ; chiral QFT ; bounded Bose fields.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics , Physics
    Notes: Abstract Nontrivial chiral Bose fields living on a light ray are necessarily unbounded. The only bounded Fermi fields are free fields.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1436-5065
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geography , Physics
    Notes: Summary The Austrian city of Graz at the south-eastern edge of the Alps frequently experiences wintertime stagnations during anticyclonic flow conditions, leading to high local concentrations of primary pollutants. This paper investigates the dominant three-dimensional local flow structures in the Graz region during a representative January stagnation period in 1998 using data obtained from a field experiment that supplemented the routine meteorological network with an array of sodars and tethersondes and a meteorological tower. Important modifications to the temperature and wind fields over Graz and its surroundings are attributed to both topographical and urban effects. The main modifications to the along-valley wind system in the Mur valley that runs through Graz from north to south are caused by near-surface temperature field differences between a warmer north and a cooler south part of the city and the regular development of a nighttime down-valley low-level jet and its upward lifting when crossing the city centre.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1438-2385
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1438-2385
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Chemie Ingenieur Technik - CIT 67 (1995), S. 1173-1173 
    ISSN: 0009-286X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
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