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  • 1’-Ethylidenebis (L-tryptophan)  (1)
  • Ultrastructure
  • cultured cells
  • 1995-1999  (1)
  • 1
    ISSN: 1432-0738
    Keywords: Key words Eosinophilia-myalgia syndrome ; L-Tryptophan ; 3-(Phenylamino) alanine ; Rat ; 1 ; 1’-Ethylidenebis (L-tryptophan)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Consumption of certain product lots of L-tryptophan (LT) has been reported to be epidemiologically associated with an outbreak of eosinophilia-myalgia syndrome (EMS) in the United States. Since the production lots were found to contain 3-phenylamino alanine (PAA) as an impurity, its effects were studied by administering the substance orally by gavage to 5-week-old Sprague-Dawley rats. Groups of animals were given PAA for 13 consecutive weeks at dose levels of 1, 10 and 100 mg/kg per day. The animals were killed at 4 or 8 weeks. Hematological and blood biochemical tests were performed and detailed histopathological observations were made. No significant abnormalities were observed in the test animals and in particular no EMS-like conditions. A brief summary of other animal studies using several species of rats and mice performed in our laboratory since 1989 on various LT related substances is also presented. No EMS-like effects were observed in these studies.
    Type of Medium: Electronic Resource
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