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  • 1
    ISSN: 1573-7209
    Keywords: Cervical neoplasia ; dysplasia ; neovascularization ; vascular endothelial growth factor ; vascular permeability factor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Cervical intraepithelial neoplasia (CIN) lesions elicit a neovascularization response at the stromal–epithelial junction. In this study, the angiogenic properties of histologically benign cervical epithelium adjacent to CIN were compared to samples of normal cervix from patients with no evidence of CIN. Vessels were detected by immunohistochemical staining for von Willebrand factor (vWf). Expression of a potent angiogenic factor, vascular endothelial growth factor/vascular permeability factor (VEGF/VPF), was measured by in situ hybridization. Statistical comparisons were made using the Student t-test. In histologically benign cervix adjacent to CIN, the microvessel count was significantly increased (164.5 versus 47.3 vessels/cm; p 〈 0.004) and vessels were more closely apposed to the epithelium (15.3 versus 22.4 μm to the basal cell nuclei; p 〈 0.0001) than in normal cervix. Expression of VEGF/VPF was rare in normal cervix but was detectable in more than 90% of sample s of benign epithelium adjacent to CIN. Therefore, vWf staining and VEGF/VPF expression are more sensitive at identifying nearby CIN than conventional histology.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1971
    Keywords: Key words: Three-dimensional echocardiography — Atrial septal defects — Ventricular septal defects — Congenital heart disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Dynamic three-dimensional echocardiographic reconstructions of 27 cardiac septation defects were performed in 19 sedated infants and children. Using a subxiphoid rotational scanning approach, complete visualization of the entire shape and breadth of the defect was attained in 11 of 16 ventricular septal defects and 9 of 11 atrial septal defects. This technique enabled the operator to cut slices from the three-dimensional block of echocardiographic data in order to present septation defects in a region- or lesion-oriented fashion. Poor baseline two-dimensional image quality and certain small septation defects that were readily obscured by nearby structures led to inadequate three-dimensional reconstructions. The application of dynamic three-dimensional echocardiography for assessment of cardiac septation defects uniquely provided (1) the ability to present en face views of atrial and ventricular septal defects; and (2) a means by which intracardiac anatomy can be displayed in a region- and lesion-oriented fashion for interventional and surgical planning purposes.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    HEC forum 11 (1999), S. 77-82 
    ISSN: 1572-8498
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Philosophy
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1530-0358
    Keywords: Anus ; Squamous intraepithelial lesion ; Colposcopy ; Human immunodeficiency virus ; Anal cancer ; Anal intraepithelial neoplasia ; Anoscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract PURPOSE: The incidence of anal cancer is increased in men with a history of anal receptive intercourse. Analogous to cervical cancer, whose precursor is cervical high-grade squamous intraepithelial lesion (HSIL), anal cancer may be preceded by anal HSIL. Although not yet proven, detection, follow-up, and treatment of HSIL may prevent development of anal cancer. Cervical colposcopic methodology was used to describe anal lesions and to determine if HSIL could be distinguished from low-grade squamous intraepithelial lesion (LSIL). METHODS; The colposcopic characteristics of 385 biopsied anal lesions were described and correlated with results of histopathology in a cohort of 121 human immunodeficiency virus-positive and 31 human immunodeficiency-negative homosexual/bisexual men with anal lesions followed as part of a longitudinal study of anal squamous intraepithelial lesions. Color, contour, surface, and vascular patterns of anal lesions were analyzed and correlated with histologic diagnosis. RESULTS: Sixty-seven percent of biopsies showed LSIL and 26 percent showed HSIL. The positive predictive value for anal HSIL in lesions with characteristics typical of cervical LSIL was 7.7 percent (95 percent confidence interval, 1.8–14), whereas the positive predictive value for anal HSIL in lesions with characteristics typical of cervical HSIL was 49 percent (95 percent confidence interval, 40–58). CONCLUSIONS: The colposcopic appearance of different grades of anal squamous intraepithelial lesions was similar to those described for the cervix. Incorporation of colposcopy into assessment of anal disease could aid in distinguishing anal LSIL from HSIL.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1572-946X
    Keywords: artificial satellites ; space probes - surveys - ultraviolet: general - catalogues - stars: activity ; atmospheres ; binaries ; white dwarfs
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract This paper discusses the first all-sky surveys of cosmic extreme ultra-violet and soft X-ray sources, discovered by ROSAT. Details of the surveys are presented, with comparisons made to previous selected surveys in the X-ray regime. The subsequent optical identification programs are described, and the major results summarized. We then discuss the main classes of EUV emitters: active chromosphere stars and hot white dwarfs, and describe the importance of EUV observations in understanding the astrophysics of these objects. Many bright, and relatively nearby, sources have been identified as hitherto unrecognized active stars, representing the extremes in chromospheric and coronal activity, be it binary or age related. Many new hot DA white dwarfs have also been indentified, and the most exciting result in this area is the discovery that significant traces of heavier elements (e.g. C, N, O, Si, Fe and Al) exist in their atmospheres, substantially increasing their EUV opacities. The importance of hot white dwarfs as “standard candles” in probing the local interstellar medium is also discussed. Miscellaneous counterparts (AGN, PNN, O-B stars and CVs) that make up the rest of the sample of EUV sources are also briefly mentioned. We finish with a discussion of the on-going ROSAT Galactic Plane Survey (RGPS) identification program.
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Astrophysics and space science 226 (1995), S. 27-30 
    ISSN: 1572-946X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Light curves of the nova remnant V841 Oph, obtained on seven nights in 1985, are presented. Flickering occurs on all timescales from at least as short as 100 s to many hours. No periodic modulations were found. Further spectroscopic or infrared observations are recommended in order to verify the orbital period.
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