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  • 1
    ISSN: 1420-908X
    Keywords: Key words: YPE-01 — Diarylheptanoid — 5-Lipoxygenase — Leukotriene — Ear edema
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Objective and Design: We investigated the anti-inflammatory effect of YPE-01, a novel diarylheptanoid derivative in vitro and in vivo.¶Material: In the in vitro study, rat basophilic leukemia (RBL-1) cells were used. For the in vivo study, ICR and ddY mice (male, 7 weeks old) were used.¶Treatment: In the in vitro study, the supernatant of RBL-1 cells lysate was incubated with 50 μM arachidonic acid (AA) and 0.01-100 μM test drugs for 15 min. RBL-1 cells were preincubated with 0.01–100 μM test drugs for 10 min before incubation with 0.5 μM calcium ionophore A23187 for 10 min. In the in vivo study, YPE-01 (0.1–3 mg/ear) was applied to the ear of mice at the same time as a 12-O-tetradecanoylphorbol 13-acetate (TPA) application or 1 h before an AA application.¶Methods: In the in vitro study, the amounts of 5-hydroxyeicosatetraenoic acid and leukotrienes were measured by high-performance liquid chromatography and an enzyme immunoassay, respectively. In the in vivo study, a circular tissue sample from the ear of the mice was weighed. Statistical analysis was done using Dunnett's test.¶Results: YPE-01 inhibited the 5-lipoxygenase activity (IC50, 0.28 μM) and the leukotriene B4 (IC50, 0.035 μM) and C4 (IC50, 0.046 μM) production by RBL-1 cells without any inhibition of cyclooxygenase activity in vitro. The topical application of YPE-01 significantly suppressed both the AA- and TPA-induced ear edemas in vivo.¶Conclusions: YPE-01 is a selective 5-lipoxygenase inhibitor with a suppressive effect against dermal inflammation.
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  • 2
    ISSN: 1434-601X
    Keywords: PACS: 23.60.+e nbsp;decay – 25.70.Gh Compound nucleus – 27.80.+w 190 ≤ A ≤ 219
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract: The α-decay energy and halflife of 195mAt were determined to be 6960±20 keV and 385+69 −51 ms respectively, on the basis of genetic correlations in the 169Tm(36Ar, α6n)195At reaction, while those of 195gAt measured simultaneously were 7105±30 keV and 146+21 −17 ms respectively, reconfirming the previously reported values. A new isotope 199Fr was also produced and identified in the same way in the 169Tm(36Ar, 6n)199Fr reaction, yielding Eα= 7655±40 keV and T1/2= 12+10 −4 ms.
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  • 3
    ISSN: 1434-4726
    Keywords: Key words Acoustic reflex ; Middle ear muscle ; Clinical loudness
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The relationship between the acoustic reflex threshold (ART) and loudness was examined in patients with unilateral hearing losses and subjects with simulated hearing losses using a masking method. Significant differences in the ART between the two ears of patients with unilateral hearing losses were correlated with differences in loudness at the level of the ART with differences in loudness determined by the alternate binaural loudness balance test. A similar relationship of ART and the sensation of loudness was also observed in ears with simulated hearing losses. The results obtained in the present study suggest a positive relationship between the ART and loudness, and provide some support for the assumption that a common neuronal information pathway plays an important role both in producing the loudness and eliciting the acoustic reflex.
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  • 4
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The proliferative activity of the long junctional epithelium (LJE) in rats was examined using stains for argyrophilic proteins of the nucleolar organizer region (AgNORs protein). The LJE was experimentally produced by insertion of a rubber piece between maxillary molars for 1 wk. After removal of the rubber, the length and AgNORs parameters of the LJE were measured and analyzed statistically. The LJE widely covered the apical side of the exposed root surface 4 wk after the removal. Its length was longest after 4 and 8 wk; it became shorter subsequently. The AgNORs were visible as black dots of various sizes and numbers on the sections. A high potential for proliferation was obvious in the LJE after 4 wk and was maintained until 12 wk after the removal. The AgNORs ratio on the connective tissue interface of the LJE was about twice of that of normal junctional epithelium after 4–12 wk. The proliferative activity on the root surface side was slightly increased after 4 wk. There was no significant difference in proliferative activity between the coronal and apical sides. These results suggest that the proliferative activity of the LJE is maintained continuously at a high level on the connective tissue interface supplying the epithelial cells. Basal cells proliferate at the connective tissue interface of the LJE, migrate directly to the root surface or via the apical portion and finally desquamate from the surface of the epithelium.
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  • 5
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The proliferative activity of the long junctional epithelium (LJE) in rats was examined using stains for argyrophilic proteins of the nucleolar organizer region (AgNORs protein). The LJE was experimentally produced by insertion of a rubber piece between maxillary molars for 1 wk. After removal of the rubber, the length and AgNORs parameters of the LJE were measured and analyzed statistically. The LJE widely covered the apical side of the exposed root surface 4 wk after the removal. Its length was longest after 4 and 8 wk; it became shorter subsequently. The AgNORs were visible as black dots of various sizes and numbers on the sections. A high potential for proliferation was obvious in the LJE after 4 wk and was maintained until 12 wk after the removal. The AgNORs ratio on the connective tissue interface of the LJE was about twice of that of normal junctional epithelium after 4-12 wk. The proliferative activity on the root surface side was slightly increased after 4 wk. There was no significant difference in proliferative activity between the coronal and apical sides. These results suggest that the proliferative activity of the LJE is maintained continuously at a high level on the connective tissue interface supplying the epithelial cells. Basal cells proliferate at the connective tissue interface of the LJE, migrate directly to the root surface or via the apical portion and finally desquamate from the surface of the epithelium.
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  • 6
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We have previously shown that tumor necrosis factor-a (TNF-α) reduces interleukin-4 (IL-4)-induced Fce RII expression in human monocytes. It has been shown that TNF-α activates nuclear transcriptional factors through the generation of reactive oxygen intermediates (ROIs), and antioxidant N-acetylcysteine (NAC) inhibits TNF-α-induced activation of nuclear transcriptional factors. Therefore, we hypothesized that TNF-α-dependent reduction of IL-4-induced Fce RII expression in monocytes might be mediated through the ROIs-activated mechanism. In the present study, to test our hypothesis, we examined the effect of NAC on TNF-α-dependent reduction of IL-4-induced FcɛRII expression in human monocytes. NAC attenuated TNF-α-dependent reduction of IL-4-induced Fcɛ RII expression by attenuating TNF-a-dependent reduction of Fcɛ RII mRNA expression. Similarly, the structurally unrelated antioxidant, pyrrolidine dithiocarbamate (PDTC), also effectively attenuated this reduction. These results indicate that an ROIs-activated and antioxidant-sensitive mechanism might be involved in TNF-α-dependent reduction of IL-4-induced FcɛRII expression in monocytes.
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  • 7
    Electronic Resource
    Electronic Resource
    Chester : International Union of Crystallography (IUCr)
    Journal of synchrotron radiation 5 (1998), S. 374-375 
    ISSN: 1600-5775
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Geosciences , Physics
    Notes: A new crowbarless power supply is to be installed at the New SUBARU storage ring. A high-power switching inverter unit eliminates the need for expensive and unstable crowbar circuits for the klystron power supply. It also realizes a very small voltage ripple in the low-frequency region. This is an important characteristic, especially in a quasi-isochronous storage ring such as New SUBARU.
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  • 8
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background: RANTES plays an important role in the production of allergic inflammation of the airway through its chemotactic activity for eosinophils. However, the intracellular signal regulating RANTES expression in human pulmonary vascular endothelial cells has not been determined. In the present study, therefore, we examined the role of p38 mitogen-activated protein (MAP) kinase in RANTES production by tumor necrosis factor (TNF)-α-stimulated pulmonary vascular endothelial cells in order to clarify the signal transduction pathway regulating RANTES production by pulmonary vascular endothelial cells. Methods: We examined p38 MAP kinase activation, and the effect of SB 203580, as the specific inhibitor for p38 MAP kinase, on p38 MAP kinase activity and RANTES production by TNF-α-stimulated human pulmonary vascular endothelial cells. Results: The results showed that TNF-α induced RANTES production and p38 MAP kinase activity in human pulmonary vascular endothelial cells. Abrogation of p38 MAP kinase activity by SB 203580 repressed TNF-α-induced p38 MAP kinase activity and RANTES production. Conclusions: These results indicate that p38 MAP kinase plays an important role in the TNF-α-activated signaling pathway which regulates RANTES production by human pulmonary vascular endothelial cells.
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  • 9
    ISSN: 1573-7357
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Tunneling measurements of (Bi,Pb) 2 Sr 2 Ca 2 Cu 3 O 10+δ have been carried out with break junction to study the gap feature above T c = 106 K. The decreasing gap magnitude with increasing the temperature does not disappear at T c for the most significant data. The gap-closing temperature is found to be T* ≃ 160 K.
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  • 10
    ISSN: 1600-5775
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Geosciences , Physics
    Notes: The aims of the New SUBARU project are to promote industrial applications in the VUV and soft X-ray region and to develop research and development towards new light sources. The main facility of the New SUBARU project is the 1.5 GeV electron storage ring which is under construction at the SPring-8 site in Harima Science Garden City, Japan. The storage ring is quasi-isochronous and has variable momentum dispersion for the deep study of beam dynamics in very short bunches.
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