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  • 1
    Call number: L301:21
    Keywords: Immunologic Deficiency Syndromes ; Neoplasms, Experimental / immunology ; Disease Models, Animal
    Pages: xiii, 229 p. : ill.
    ISBN: 9783805562706
    Signatur Availability
    L301:21 departmental collection or stack – please contact the library
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Cancer chemotherapy and pharmacology 37 (1995), S. 211-221 
    ISSN: 1432-0843
    Keywords: Treosulfan ; Alkylating agent ; Antitumor activity ; Small-cell lung carcinomas ; Non-small-cell lung carcinomas
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Treosulfan (l-threitol 1,4-bismethanesulfonate, Ovastat) is an alkylating agent and a structural analogue of busulfan. It has been established in the clinical chemotherapy of human ovarian carcinomas for several years and has additionally been shown to be effective against xenografted human breast carcinomas. No other human carcinoma is yet known to be sensitive to treosulfan. The present study confirms the pronounced and significant antitumor activity of treosulfan against heterotransplanted human lung carcinomas of both the small-cell and the non-small-cell type. Treosulfan reduced the growth of all four small-cell lung carcinomas that were investigated in a significant manner. It was even more active than equitoxic doses of the clinically approved cytostatics ifosfamide, cisplatin, and etoposide toward three of them and induced long-lasting growth reductions (60–98% of control tumor size) corresponding to partial and nearly complete remissions. In the case of the nine non-small-cell lung carcinomas investigated, treosulfan effected significant growth inhibition of more than 50%, again in all of them, and was more active than the comparative compounds ifosfamide, mitomycin C, and cisplatin at least in one of four epidermoid lung carcinomas, one large-cell carcinoma, and one of three lung adenocarcinomas. These results are remarkable and unexpected, and the present study should be followed rapidly by phase II clinical trials of treosulfan against human lung carcinomas of both the small-cell and the non-small-cell type.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-0703
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Notes: Abstract In situ and laboratory bioassays using the eastern oyster, Crassostrea virginica, were undertaken in the Wright River Estuary, South Carolina, to determine the toxic potential of effluent and sediment from recently dredged sediments. Current standards (ASTM, USEPA, and USACE) rely solely on laboratory-based bioassays to assess toxicity of dredge spoils prior to disposal. These bioassays do not necessarily replicate the natural physicochemical estuarine processes, limiting the environmental realism of this approach. In this study, oysters were collected from a site on Leadenwah Creek (SC) and deployed in plastic cages anchored above the sediment and within the intertidal zone for 90 days at four dredge spoil disposal areas (18 sites total, one bushel/site). Oysters were also deployed at a reference site (New River Estuary, SC) and the original collection site. Trace metals and polycyclic aromatic hydrocarbons (PAHs) in tissue, sediment, and effluent samples as well as the assessment of oyster health in adults (% mortality and % reduction in potential yield) and larvae (larval development) were measured. Results indicated high arsenic concentrations in surface water samples (〈10 to 147 μg/L), some of which exceeded the USEPA chronic marine water quality criteria and sediment concentrations (〈1.0–82.2 mg/kg), which also exceeded the ERM (70 mg/kg) and the ERL (8.2 mg/kg) for arsenic, and which may have contributed to the toxic response seen in deployed oysters. A positive relationship was also seen between the in situ percent reduction in potential yield and laboratory-derived data from larval oyster development bioassays. The advantage of the combined in situ/laboratory approach used in this study is the ability to resolve probable factors influencing the toxicity of these effluents to oysters.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-0703
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Notes: Abstract. In situ and laboratory bioassays using the eastern oyster, Crassostrea virginica, were undertaken in the Wright River Estuary, South Carolina, to determine the toxic potential of effluent and sediment from recently dredged sediments. Current standards (ASTM, USEPA, and USACE) rely solely on laboratory-based bioassays to assess toxicity of dredge spoils prior to disposal. These bioassays do not necessarily replicate the natural physicochemical estuarine processes, limiting the environmental realism of this approach. In this study, oysters were collected from a site on Leadenwah Creek (SC) and deployed in plastic cages anchored above the sediment and within the intertidal zone for 90 days at four dredge spoil disposal areas (18 sites total, one bushel/site). Oysters were also deployed at a reference site (New River Estuary, SC) and the original collection site. Trace metals and polycyclic aromatic hydrocarbons (PAHs) in tissue, sediment, and effluent samples as well as the assessment of oyster health in adults (% mortality and % reduction in potential yield) and larvae (larval development) were measured. Results indicated high arsenic concentrations in surface water samples (〈10 to 147 μg/L), some of which exceeded the USEPA chronic marine water quality criteria and sediment concentrations (〈1.0–82.2 mg/kg), which also exceeded the ERM (70 mg/kg) and the ERL (8.2 mg/kg) for arsenic, and which may have contributed to the toxic response seen in deployed oysters. A positive relationship was also seen between the in situ percent reduction in potential yield and laboratory-derived data from larval oyster development bioassays. The advantage of the combined in situ/laboratory approach used in this study is the ability to resolve probable factors influencing the toxicity of these effluents to oysters.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-136X
    Keywords: Vasopressin ; Cortisol ; Hyperglycemic effect ; Pituitary adrenal axis ; Ruminants
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The present study compared the effects of vasopressin on plasma concentrations of corticotropin, cortisol and glucose in cattle and sheep. After intravenous injection of 1, 0.1 and 0.01 μg vasopressin per kg body weight, the plasma vasopressin concentration increased proportionally to the injected dose, and this increase was similar in cattle and sheep. Doses of 1 and 0.1 μg per kg body weight of vasopressin triggered significant responses of corticotropin, cortisol and glucose in cattle and sheep. The corticotropin response to both doses was significantly greater in sheep, whereas the glucose response was greater in cattle. The cortisol response did not differ between species. The lowest dose of vasopressin (0.01 μg per kg body weight) still induced a significant cortisol response without a substantial effect on plasma corticotropin, suggesting that a direct action of vasopressin on the adrenals may contribute to the observed cortisol response. The results demonstrate that vasopressin increases plasma levels of corticotropin, cortisol and glucose in cattle, as it does in sheep, but the intensities of the corticotropin and glucose responses to vasopressin differ between cattle and sheep. The reasons for these differences remain to be clarified.
    Type of Medium: Electronic Resource
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