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  • 1995-1999  (2)
  • 1
    ISSN: 1432-1289
    Keywords: Schlüsselwörter Takayasu-Arteriitis ; Rasch progressive Glomerulonephritis ; RPGN
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Die Takayasu Arteriitis ist eine in Europa seltene Erkrankung, die die Aorta und ihre großen Äste sowie die Pulmonalarterien befallen kann. In 40–62% der Fälle kommt es zu einem Befall der Nierenarterien, was zu einem ischämischen Nierenschaden und zu einer renovaskulären Hypertonie führen kann. Jedoch sollte auch bei fehlendem Nachweis eines Nierenarterienbefalls eine engmaschige nephrologische Kontrolle und gegebenenfalls eine frühzeitige Nierenpunktion erfolgen, da die seltenen Glomerulonephritiden bei Takayasu Arteriitis initial in der Regel ein gutes Ansprechen auf Steroide zeigen. Der hier vorliegende Fall beschreibt die sehr seltene Assoziation einer Takayasu Arteriitis mit einer rasch progressiven Glomerulonephritis.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1440
    Keywords: Key words Diadenosine polyphosphates ; Ca2+ ATPase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Diadenosine tri-, tetra-, penta-, and hexaphosphate (Ap3A, Ap4A, Ap5A and Ap6A) have been described as having various effects on vascular tone depending on the number of phosphate groups. This study examined the effect of diadenosine polyphosphates on Ca2+ ATPase activity. The activity of the enzyme was measured spectrophotometrically as the difference in hydrolysis of ATP in the presence and absence of Ca2+ with various concentrations of ATP and diadenosine polyphosphates. The diadenosine polyphosphates increased the activity of the Ca2+ ATPase. The effect tended to be stronger with Ap5A and Ap6A than with Ap3A and Ap4A in the order of potency: Ap3A≈AP4A〈Ap5A≈AP6A. The stimulatory effect of diadenosine polyphosphates was not competitive with that of ATP, suggesting an allosteric activation of Ca2+ ATPase by diadenosine polyphosphates. This effect may be physiologically relevant for limiting the increase in cytosolic free Ca2+ concentration elicited by diadenosine polyphosphates by receptor activation and modulating Ca2+ ATPase function under resting conditions.
    Type of Medium: Electronic Resource
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