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  • 1
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    Philadelphia : Lippincott-Raven
    Call number: 08-MR Ber
    Keywords: NMR-Tomographie ; System / muskuloskeletal ; Musculoskeletal system / Magnetic resonance imaging ; Bone Diseases / diagnosis ; Muscular Diseases / diagnosis ; Magnetic Resonance Imaging
    Pages: xiii, 954 p. : ill.
    Edition: 3rd ed.
    ISBN: 0781703107
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  • 2
    Call number: 01-SichIng:285
    Keywords: Occupational Health ; Technology, Medical Laboratory
    Pages: xvii, 333 p. : ill.
    ISBN: 3-540-61952-6
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  • 3
    ISSN: 1432-1130
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Solid state phase epitaxy (SSPE) by rapid thermal processing (RTP) of Co/Ti double layers deposited on (100)-Si substrates is a common technique for the production of buried CoSi2-silicide conducting layers for microelectronics technology. The understanding of the processes during the SSPE silicide formation on the atomic scale needs the study of the elemental depth distributions with nanometer scale depth resolution of all multi-layer elemental constituents at different RTP conditions. A new experimental technique, the laterally resolved TXRF analysis line scan method across the bevelled section of the sample prepared by ex-situ ion beam sputter etching, was used to obtain the multi-element depth profiles. First results on the as evaporated Co/Ti (30 nm thick) double layer system prior to the RTP and on the final CoSi2/TixCoySiz-system (160 nm thickness) after the RTP were obtained.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-1173
    Keywords: Schlüsselwörter Berufsdermatosen ; Begutachtung ; Psychotherapeutische Medizin ; Rechtliche Grundlagen ; Multiple chemical sensitivity ; Key words Occupational dermatoses ; Expertise ; Psychotherapeutic medicine ; Legal grounds ; Multiple chemical sensitivity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Skin diseases, the psyche and psychological changes are often intertwined, especially in patients presenting for expert dermatologic opinion. In many cases an additional evaluation provided by psychotherapeutic medicine may be necessary. This resource may help with the diagnosis, explanation of the problem and estimation of the degree of disability. The different legal guidelines of the various evaluation boards must be considered. The role of psychotherapeutic evaluation is demonstrated through case examples. The evaluation of new possibly occupationally-related disorders such as multiple chemical sensitivity and mobbing is considered.
    Notes: Zusammenfassung Zwischen Haut und Psyche sowie psychischer Alteration bestehen bei vielen Dermatosen wechselseitige Zusammenhänge, die auch in Begutachtungssituationen zutagetreten können. In bestimmten Fällen kann daher eine Zusatzbegutachtung durch die psychotherapeutische Medizin erforderlich werden, insbesondere wenn daraus neue Erkenntnisse zur Aufklärung, Diagnosesicherung oder Einschätzung der Minderung der Erwerbsfähigkeit (MdE) resultieren. Die unterschiedlichen rechtlichen Grundlagen der verschiedenen Rehabilitationsträger sind dabei zu berücksichtigen. Die unterschiedlichen Indikationen zur Zusatzbegutachtung durch die psychotherapeutische Medizin werden anhand von konkreten Gutachtensbeispielen dargestellt. Die Wertung neuer möglicherweise berufsassoziierter Erkrankungen wie z.B. „multiple chemical sensitivity” und Mobbing wird diskutiert.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-0983
    Keywords: allR ; Aflatoxin ; Secondary metabolism ; Zinc binuclear cluster
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Under limiting growth conditions,Aspergillus nidulans produces a carcinogenic secondary metabolite related to aflatoxin and called sterigmatocystin (ST). The genes for ST biosynthesis are co-ordinately regulated and are all found within an approximately 60-kilobase segment of DNA. One of the genes within this region is predicted to encode a CX2CX6CX6CX2CX6CX2 zinc binuclear cluster DNA-binding protein that is related to theAspergillus flavus andAspergillus parasiticus aflatoxin regulatory geneaflR. Deletion of theA. nidulans aflR homolog resulted in an inability to induce expression of genes within the ST gene cluster and a loss of ST production. BecauseA. nidulans aflR mRNA accumulates specifically under conditions that favor ST production we expect that activation of ST biosynthetic genes is determined byA. nidulans aflR. In support of this hypothesis, we demonstrated that induced expression of theA. flavus aflR gene inA. nidulans, under conditions that normally suppress ST gene expression, resulted in activation of genes in the ST biosynthetic pathway. This result demonstrates that AflR function is conserved betweenAspergillus spp. and thataflR expression is sufficient to activate genes in the ST pathway.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-1130
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The capability of a modern interpretation system for IR spectra has been tested, in which the process of structural assignment is modelled by methods of fuzzy logic. Figures of merit were generated for different interpretation algorithms. These figures of merit permit the validation as well as a comparison of independent interpretation systems. The influence of the sample preparation practice onto the information content of the resulting spectrum has been evaluated as well. Automatically generated band tables show only restricted reliability.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-1041
    Keywords: Keywords Polypharmacy (PP) ; Epidemiology ; Men
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Objective: To describe the pattern of polypharmacy (PP) among older men and to relate medication use to personal, social and medical information. Methods: Information on medication use, both prescribed and `over the counter' (OTC), was collected from 1906 men, aged 56–75 years, observed on up to four occasions since 1979 in a community survey – the Caerphilly prospective study. On each visit, a variety of questionnaires regarding personal, social and medical factors were completed, and a brief medical examination was conducted. Medication use was related to some of the questionnaire information and biological measurements collected in order to identify factors associated with PP. Results: A quarter of the men (475/1906) reported using three or more prescription-only medicines (PoMs), with 9% (163) using five or more (major PP). PP was related to increasing age, lower social class, not being in employment, smoking and obesity (high body mass index). Men with a medical history, especially of high blood pressure, angina, heart attack, or hospital admission in the last 5 years, comprised a large proportion of those on major PP. Higher levels of PoM use by this group had been apparent over the previous 14 years. Men on PP reported lower levels of self-rated health and higher rates of non-PoM use. Cardiovascular and, to a lesser extent, central nervous and respiratory system drugs were the main medicines used by men on major PP. Conclusions: PP is common among men aged 56–75 years in Caerphilly, South Wales. It is related to many personal, social and medical factors, and associated with lower self-rated health status and greater use of non-PoMs. Cardiovascular medicines are the main contributor to major PP. Those on PP require regular review and, where possible, PP should be reduced as it has many potential adverse effects.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Using polymerase chain reaction, interleukin-6 (IL-6) cDNA fragments from harbor seal (Phoca vitulina), killer whale (Orcinus orca), and Southern sea otter (Enhydra lutris nereis) were cloned and sequenced. For all three species, a continuous open reading frame encoding 203 residues for harbor seal, 199 residues for killer whale, and 201 residues fro sea otter with stop codons located at analogous positions were identified. These fragments correspond to nucleotides 71–753 of the humanIL-6 transcript and represent 96% of the complete coding nucleotides. Comparison of these marine mammal sequences with other published mammalianIL-6 cDNA demonstrated that both harbor seal and sea otterIL-6 had most similarity to that of other terrestrial carnivores (Mustelidae and Canidae), while killer whale had highest identity with ruminants (Bovidae and Ovidae). Among the three marine mammal species characterized, as well as cDNA sequences from nine other species, 40 invariant amino acids, including a number of residues situated at the putative gp80 and gp130 receptor binding sites, were identified. The presence of invariant amino acids within the receptor-binding portion of IL-6 for twelve different species suggests these positions are essential for biological activity of IL-6 and, moreover, likely account for the cross-reactivity among different mammalian IL-6-like activities in mouse bioassays. An additional significant finding was the presence of several variant residues only within the mouse putative IL-6 receptor binding region, which may account for observations of restricted cross-reactivity of mouse IL-6-like activity in human bioassays. Together, these findings provide insights into the evolution of the mammalianIL-6 gene and additional valuable information regarding amino acid residues essential for the biological activity of mammalian IL-6.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract  Using polymerase chain reaction, interleukin-6 (IL-6) cDNA fragments from harbor seal (Phoca vitulina), killer whale (Orcinus orca), and Southern sea otter (Enhydra lutris nereis) were cloned and sequenced. For all three species, a continuous open reading frame encoding 203 residues for harbor seal, 199 residues for killer whale, and 201 residues for sea otter with stop codons located at analogous positions were identified. These fragments correspond to nucleotides 71 – 753 of the human IL-6 transcript and represent 96% of the complete coding nucleotides. Comparison of these marine mammal sequences with other published mammalian IL-6 cDNA demonstrated that both harbor seal and sea otter IL-6 had most similarity to that of other terrestrial carnivores (Mustelidae and Canidae), while killer whale had highest identity with ruminants (Bovidae and Ovidae). Among the three marine mammal species characterized, as well as cDNA sequences from nine other species, 40 invariant amino acids, including a number of residues situated at the putative gp80 and gp130 receptor binding sites, were identified. The presence of invariant amino acids within the receptor-binding portion of IL-6 for twelve different species suggests these positions are essential for biological activity of IL-6 and, moreover, likely account for the cross-reactivity among different mammalian IL-6-like activities in mouse bioassays. An additional significant finding was the presence of several variant residues only within the mouse putative IL-6 receptor binding region, which may account for observations of restricted cross-reactivity of mouse IL-6-like activity in human bioassays. Together, these findings provide insights into the evolution of the mammalian IL-6 gene and additional valuable information regarding amino acid residues essential for the biological activity of mammalian IL-6.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1433-0385
    Keywords: Key words: Bilitec ; Gastroduodenal motility ; Duodenogastric reflux ; BI resection. ; Schlüsselwörter: Bilitec ; gastroduodenale Motilität ; duodenogastraler Reflux ; Billroth-I-Resektion.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung. Wir kombinierten ein neu entwickeltes fiberoptisches ambulantes Meßsystem zur Bestimmung von intragastralem Bilirubin (Bilitec 2000®, Synectics Medical Inc., Schweden) mit der gastroduodenalen Langzeitmanometrie bei 10 gesunden Probanden und 10 beschwerdefreien Patienten nach Billroth-I-Resektion (BI-Resektion). Im Vergleich zur Kontrollgruppe war die circadiane Bilirubinexposition und die Anzahl exzessiver Schwankungen der intragastralen Bilirubinkonzentration (mehr als 20 % und länger als 5 min) bei den BI-resezierten Patienten signifikant erhöht (p 〈 0,05). Der interdigestive Motilitätszyklus (IMC) war bei den Patienten durch das gehäufte Auftreten verschiedener Typen abnormal propagierter Phase-III-Aktivitätsfronten gekennzeichnet. 90,1 % aller Bilirubinanstiege gingen in der Patientengruppe zeitlich mit abnormalen propagierten Phase-III-Aktivitätsfronten einher. In Fällen eines erhöhten duodenogastralen Refluxes erscheint die ambulante intragastrale Bilirubinbestimmung in Kombination mit der gastroduodenalen Langzeitmanometrie als praktikable Methode zum circadianen Monitoring von Motilität und Reflux.
    Notes: Summary. We combined a newly developed ambulatory fiberoptic system for detecting intragastric bilirubin (Bilitec 2000, Synectics Medical Inc., Sweden) with prolonged measurement of gastroduodenal motility in 10 healthy volunteers and 10 patients following BI resection. Circadian intragastric bilirubin exposure and the total number of tremendous changes of bilirubin absorption (more than 20 %, over a period of at least 5 min) were significantly increased in the BI-resected patients (P 〈 0.05). In patients the interdigestive motility cycle (IMC) was characterized by the appearance of several types of abnormally propagated phase III activity fronts. Of the tremendous increases of bilirubin absorption in the patient group, 90.1 % were associated with abnormally propagated phase III activity fronts. In cases of increased duodenogastric reflux, the combination of ambulatory intragastric bilirubin measurement and long-term manometry seems to be feasible to assess motility and reflux simultaneously.
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