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  • 1995-1999  (947)
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  • 1
    Unknown
    Planegg : WRS Verlag Wirtschaft, Recht und Steuern
    Call number: M300:284
    Keywords: Economics, Mathematical
    Pages: 298 p. + 1 Diskette
    Edition: 5., aktualisierte Aufl.
    ISBN: 3809212784
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    M300:284 available
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  • 2
    Call number: QP501Z:2/45
    Keywords: Cytoskeleton / Congresses
    Pages: viii, 160 p. : ill. (some col.)
    ISBN: 3540588175
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    QP501Z:2/45 available
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  • 3
    Unknown
    Heidelberg : Spektrum Akad. Verl.
    Call number: C0300:191
    Keywords: Combinatorical chemistry, Techniques ; Molecular Biology / methods
    Pages: 203 p. : ill.
    ISBN: 3-8274-0157-7
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    C0300:191 departmental collection or stack – please contact the library
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  • 4
    Call number: 01-Ausbildungsl:612
    Keywords: Molecular biology / Dictionaries
    Pages: 649 p. : ill.
    ISBN: 3-437-35040-4
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    01-Ausbildungsl:612 departmental collection or stack – please contact the library
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  • 5
    ISSN: 1433-0458
    Keywords: Schlüsselwörter Mukoviszidose ; Zystische Fibrose ; Menschliches Nasalepithel ; Epithelialer Na+-Kanal ; Cl ; -Sekretion ; Key words Cystic fibrosis ; Human nasal epithelium ; Epithelial Na+ channels ; Cystic fibrosis transmembrane conductance regulator ; Cl ; secretion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Cystic fibrosis (CF) is the most commonly inherited disease in Caucasians and is caused by a mutation in the gene encoding a membrane transport protein. This cystic fibrosis transmembrane conductance regulator (CFTR) is thought to be an apical Cl– channel activated by intracellular cAMP. Most recent findings suggest that CFTR is more than a pure Cl– channel and might be involved in the regulation of other transport systems. In the present study we show that CFTR as a Cl– channel plays only a minor role in primary cultured human nasal epithelium derived from non-CF and CF patients. These findings are especially of interest for non-CF human nasal epithelia in which CFTR is correctly inserted. In both tissues Cl– secretion is negligible as compared with Na+ absorption. We confirm and expand our previous observations that Na+ absorption in human nasal epithelium is the dominant ion transport process and that Cl– secretion is detectable in both CF and non-CF tissue. Moreover, we show that cAMP and ATP were not able to stimulate any silent Cl– channels in CF or non-CF human nasal epithelial cells. We further give evidence that in human nasal CF and non-CF epithelium Na+ absorption is mediated by epithelial Na+ channels (ENaC) that are either different from those of other epithelia or which exhibit altered regulation. These differences between Na+ channels of human nasal epithelium and ”classical” epithelial Na+ channels include lack of activation by the intracellular second messenger cAMP and the steroid hormone aldosterone. We show further that human nasal Na+ channels are inhibited by Cl–-channel blockers and exhibit a different pharmacology towards common Na+ channel blockers.
    Notes: Zusammenfassung Mukoviszidose [zystische Fibrose (CF)] ist die häufigste Erbkrankheit in der kaukasischen Bevölkerung. Sie wird hervorgerufen durch Mutation eines Gens, welches für ein membranständiges Transportprotein kodiert, den „cystic fibrosis transmembrane conductance regulator” (CFTR). Dieser CFTR ist in der apikalen Membran von Epithelzellen lokalisiert und fungiert dort als cAMP-aktivierbarer Cl–-Kanal. Neuere Untersuchungen haben ergeben, daß der CFTR mehr als ein normaler Cl–-Kanal ist und wahrscheinlich in die Regulation einer Reihe weiterer Transportsysteme involviert ist. In dieser Studie zeigen wir, daß der CFTR in seiner Rolle als Cl–-Kanal nur eine untergeordnete Rolle in primärkultivierten menschlichen Nasenepithelzellen von CF- und Nicht-CF-Patienten spielt. Dieses Ergebnis ist besonders für das Nasenepithel von Nicht-CF-Patienten erstaunlich, da hier der CFTR korrekt eingebaut wird. In beiden Geweben spielt also eine Cl–-Sekretion verglichen mit der Na+-Absorption eine vergleichsweise geringe Rolle. Wir bestätigen mit dieser Untersuchung unsere früheren Beobachtungen, daß im menschlichen Nasenepithel Na+-Absorption der dominierende Ionentransportprozeß ist und eine Cl–-Sekretion weder in CF- noch in Nicht- CF-Geweben in relevantem Maße vorhanden ist. Zudem zeigen wir, daß weder cAMP noch ATP irgendeine Cl–-Sekretion in CF- oder Nicht-CF-Nasenepithelzellen stimulieren können. Desweiteren ergaben sich Hinweise darauf, daß sich die epithelialen Na+-Kanäle (ENaC) im Nasenepithel, welche für einen Teil der Na+-Absorption zuständig sind, von den epithelialen Na+-Kanälen in anderen Geweben unterscheiden. Diese Unterschiede zwischen den Na+-Kanälen im menschlichen Nasenepithel und den „klassischen” epithelialen Na+-Kanälen bestehen einerseits in ihrer fehlenden Aktivierbarkeit durch den intrazellulären Botenstoff cAMP und das Steroidhormon Aldosteron. Wir zeigen weiterhin, daß menschliche nasale Na+-Kanäle durch Cl–-Kanal-Blocker gehemmt werden können und eine andere Pharmakologie auf gebräuchliche Na+-Kanal-Blocker aufweisen.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1433-8629
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Applied physics 63 (1996), S. 131-134 
    ISSN: 1432-0649
    Keywords: 42.55. Wd ; 42.81. -i ; 42.81.Qb
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract A neodymium-doped side-pumped double-clad fiber laser operating at 1.06 µm is described. We report here, what is, to our knowledge, the first exclusively repetitive side-pumping scheme with two monomode laser diodes. Side-pumping has been realized by prism-fiber couplers. A pump-light-loss analysis at the pump positions has been performed. An output power of 13.5 mW is obtained with both diode lasers. The highest slope efficiency of 66% with respect to absorbed pump power at 809 nm is achieved when pumping with only one diode.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: For direct drive inertial confinement fusion, a capsule is imploded by directly illuminating the surface with laser light. Beam smoothing and uniformity of illumination affect the seeding of instabilities at the ablation front. We have developed a technique for studying the imprint of a laser beam on a thin foil using an x-ray laser as an extreme ultraviolet (XUV) backlighter. We use multilayer XUV optics to relay the x-ray laser onto the directly driven foil, and then to image the foil modulation onto a charged coupled device camera. This technique allows us to measure small fractional variations in the foil thickness. We have measured the modulation due to imprint from a low intensity 0.35 μm drive beam incident on a 3 μm Si foil using an yttrium x-ray laser on Nova. We present results from a similar technique to measure the imprinted modulation due to a low intensity 0.53 μm drive beam incident on a 2 μm Al foil using a germanium x-ray laser at the Vulcan facility. © 1997 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: A gain saturated yttrium x-ray laser operating at a wavelength of 15.5 nm has been used as an extreme ultraviolet probe to measure optical depth modulations in a thin Si foil by face-on radiography. The high brightness of this Ne-like x-ray laser allows probing of a sample with a high opacity. This technique is sensitive to very small modulations in the optical depth of the foil, corresponding to thickness variations of a few 10 nm of cold material. This technique is used to measure the effect of direct drive laser imprint on a thin Si foil by face-on radiography using multilayer optics to image the foil with 26× magnification. We have recorded modulations in a thin Si foil that was irradiated by a 400 ps, 0.35 μm beam at an intensity of about 3×1012 W/cm2. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Transmission electron microscopy, x-ray diffraction, low-temperature photoluminescence, and Raman spectroscopy were applied to study stress relaxation and the dislocation structure in a Si-doped GaN layer in comparison with an undoped layer grown under the same conditions by metalorganic vapor phase epitaxy on (11.0) Al2O3. Doping of the GaN by Si to a concentration of 3×1018 cm−3 was found to improve the layer quality. It decreases dislocation density from 5×109 (undoped layer) to 7×108 cm−2 and changes the dislocation arrangement toward a more random distribution. Both samples were shown to be under biaxial compressive stress which was slightly higher in the undoped layer. The stress results in a blue shift of the emission energy and E2 phonon peaks in the photoluminescence and Raman spectra. Thermal stress was partly relaxed by bending of threading dislocations into the basal plane. This leads to the formation of a three-dimensional dislocation network and a strain gradient along the c axis of the layer. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
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