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  • 1995-1999  (3)
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  • 1
    ISSN: 1433-0563
    Keywords: Schlüsselwörter ARCD ; Nierenzellkarzinom ; Dialysepatienten ; Key words Renal cell cancer ; ARCD ; Hemodialysis patients
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The clinical relevance of de novo Renal Cell Cancer was compared in chronic hemodialysis patients and renal allograft recipients. Clinical course of these patients was followed for 15 years. 21 of 788 patients who underwent radical nephrectomy were suffering from renal insufficiency at the time of surgery. Evaluated data included clinical symptoms, tumor histology and clinical course. 19 patients received chronic hemodialysis treatment. 7 patients demonstrated stable function of the allograft. 92 % of patients receiving hemodialysis treatment did not show metastasis and none died of renal cell carcinoma. On the contrary, 71 % of patients who underwent renal transplantation showed advanced tumor disease or metastasis. 3 patients have died of RCC. Aggressive tumor growth of RCC requieres close follow up in patients who received a renal allograft.
    Notes: Zusammenfassung In dieser retroperspektiven Studie untersuchten wir die klinische Wertigkeit des De-novo-Nierenzellkarzinoms bei chronisch dialysepflichtigen Patienten im Vergleich zu Empfängern einer Transplantatniere. Im Zeitraum der letzten 15 Jahre beobachteten wir den klinischen Verlauf dieser Patienten. Von 788 durchgeführten Nephrektomien konnten 21 Patienten identifiziert werden, die zum Zeitpunkt der Diagnose des Nierenzellkarzinoms terminal niereninsuffizient waren. Ausgewertet wurden Daten zur klinischen Symptomatik, Tumorhistologie und zum klinischen Verlauf. 14 Patienten waren in chronischer Hämodialysebehandlung, 7 Patienten verfügten über ein stabiles Nierentransplantat. 92 % der Dialysengruppe hatte zum Zeitpunkt der Operation keine Fernmetastasen, keiner dieser Patienten ist bisher an dem RCC verstorben. 71 % der transplantierten Patienten hatte hingegen zum Zeitpunkt der Operation ein bereits organüberschreitendes Tumorwachstum oder Fernmetastasen. 3 Patienten sind zwischenzeitlich an ihrer Erkrankung verstorben. Das aggressive Tumorwachstum des Nierenzellkarzinoms in dieser Patientenpopulation macht somit eine engmaschige Kontrolle der Eigenniere vor und nach Nierentransplantation erforderlich.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A 45-year-old man with end-stage renal disease underwent a cadaveric kidney transplantation. The allograft had to be removed 10 days after transplantation because of an acute vascular rejection. After explantation, the patient suffered from a life-threatening infection withStaphylococcus epidermidis involving lungs, eyes and liver for 11 months. Despite adequate therapy including vancomycin followed by teicoplanin, he developed spondylodiscitis requiring repeated surgical interventions. The definitive cure was achieved by a sequential therapy with chloramphenicol and quinupristin/dalfopristin.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In order to elucidate the epidemiological importance of hemorrhagic fever with renal syndrome in Germany, the prevalence of antibodies against hantaviruses was determined in 13,358 sera from residents of various geographic regions, 1,284 sera from occupational risk groups and 287 sera from chronic hemodialysis patients. Serological investigations were performed using a highly specific transferable solid phase enzyme immunoassay based on the recombinant nucleocapsid proteins of a Hantaan and a Puumala serotype strain. The overall antibody prevalence was found to be 1.68 %. In the serum panels from western and southern Germany, it was determined to be 1.83 % on average in contrast to only 0.8 % in the panel from eastern Germany. An endemic focus revealing an antibody prevalence of 3.12 % was detected in a low-mountain area called Suebian Alb, which is located in the federal state of Baden-Württemberg. Occupational risk groups and a group of chronic hemodialysis patients showed a significantly elevated antibody prevalence ranging from 3.3 % to 10 %. The Puumala serotype was found to be the prevailing virus, but the percentage of sera predominantly recognizing the Hantaan nucleocapsid protein increased towards the south and the east and was significantly elevated in dialysis patients.
    Type of Medium: Electronic Resource
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