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  • 2000-2004  (1)
  • 1990-1994  (1)
  • 1
    ISSN: 1432-1041
    Keywords: Methylprednisolone aceponate ; New topical glucocorticosteroid ; efficacy ; vasoconstrictor assay ; Poison Ivy Test
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Topical glucocorticosteroids are useful in the treatment of various skin diseases. Although many corticosteroids are available today, there is still a need for highly potent compounds with minimal adverse effects. Methylprednisolone aceponate (MPA) has recently been synthesized. Its activity has been evaluated using the vasoconstrictor assay and the poison ivy test (rhus dermatitis) in 19/20 healthy volunteers of either sex. Comparable blanching was found with MPA in a cream vehicle, in an ointment and a fatty ointment. Vasoconstriction and suppression of experimentallyinduced poison ivy contact dermatitis were dose-dependent in the concentration range 0.01% to 0.5% MPA. Concentrations of MPA of at least 0.05% were significantly active. Following the highest dose, blanching was close to the maximum which can be obtained. This finding, and the improvement of rhus dermatitis, suggest that MPA belongs to the highly potent local glucocorticosteroids.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: A novel design for an airborne NOy converter was implemented, characterized in the laboratory, and used extensively for in situ tropospheric and stratospheric measurements of total reactive nitrogen (NOy). During field deployments, the converter is mounted outside the aircraft fuselage, avoiding the need for an inlet line. In flight, the converter can be calibrated by the addition of standard gases close to the sample inlet, compensating for any changes in the instrument sensitivity caused by changing operating conditions. The system has been used successfully during several Stratosphere Troposphere Experiments by Aircraft Measurements campaigns in the lowermost stratosphere and upper troposphere for the measurement of total reactive nitrogen. The detection limit of the system is approximately 100 pptv for 10 s integrated data (2σ). The precision, deduced from the reproducibility of the in-flight calibrations, is 7% and the accuracy is about 30%. Laboratory studies demonstrate that interference from HCN, NH3, and CH3CN is negligible for background conditions. © 2002 American Institute of Physics.
    Type of Medium: Electronic Resource
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