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  • 2000-2004  (32)
  • 1990-1994  (60)
  • 1
    Unknown
    Boston : Kluwer Academic Publishers
    Call number: QP624.5.D73:2
    Keywords: DNA microarrays / Data processing
    Notes: Contains papers from the second CAMDA conference, 2001.
    Pages: viii, 214 p.
    ISBN: 1402071116
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    QP624.5.D73:2 available
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  • 2
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    Boston : Kluwer Academic Publishers
    Call number: B080:135
    Keywords: DNA microarrays / Data processing
    Pages: xiv, 189 p. : ill. (some col.)
    ISBN: 0792375645
    Signatur Availability
    B080:135 departmental collection or stack – please contact the library
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  • 3
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    German Medical Science; Düsseldorf, Köln
    In:  121. Kongress der Deutschen Gesellschaft für Chirurgie; 20040427-20040430; Berlin; DOC04dgch0859 /20041007/
    Publication Date: 2004-10-07
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 4
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    German Medical Science; Düsseldorf, Köln
    In:  55. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e.V. (DGNC), 1. Joint Meeting mit der Ungarischen Gesellschaft für Neurochirurgie; 20040425-20040428; Köln; DOCMO.03.01 /20040423/
    Publication Date: 2004-04-22
    Keywords: ddc: 610
    Language: English
    Type: conferenceObject
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  • 5
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    German Medical Science; Düsseldorf, Köln
    In:  67. Jahrestagung der Deutschen Gesellschaft für Unfallchirurgie, 89. Tagung der Deutschen Gesellschaft für Orthopädie und Orthopädische Chirurgie und 44. Tagung des Berufsverbandes der Fachärzte für Orthopädie; 20031111-20031116; Berlin; DOC03dguF3-7 /20031111/
    Publication Date: 2003-11-11
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 6
    ISSN: 1432-0983
    Keywords: Yeast ; Glycerol kinase ; GUT1 ; ADR1 control
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The GUT1 gene of Saccharomyces cerevisiae, encoding glycerol kinase, was cloned and sequenced. The cloned genomic DNA fragment contains an open reading frame potentially coding for a protein of 709 amino acids with homology to bacterial glycerol kinases (40.8% identity over 502 amino acids, and 42.1% identity over 496 amino acids, in comparison to the smaller E. coli and B. subtilis enzymes). Disruption of GUT1 showed that the gene is required for growth on glycerol, but not on glucose or ethanol media. No glycerol kinase activity was detected in the disruption mutant. According to enzyme activity and transcript analysis, synthesis of glycerol kinase is repressed by glucose, and derepression is ADR1-dependent.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract A sample of 114 primary breast tumors and corresponding constitutional DNA were tested for loss of heterozygosity (LOH) of the YNZ22 and p53 genes, both located in the 17p13 region. Loss of the p53 allele was found in 28 of 44 primary breast carcinomas (64%). In contrast LOH in only 26 of 61 tumors (43%) was detected with the variable number of tandem repeats (VNTR) probe YNZ22 mapping at 17p13.3 close to the p53 locus at 17p13.1. Among 19 tumors informative for both probes allele loss at 17p13.3 never occurred without p53 involvement. These data suggest, that p53 is the target of 17p13 allelic deletions in human breast cancer. Immunohistochemistry showed overexpression of the p53 protein in 25 of 50 cases (50%) presumably reflecting activating point mutations. Overexpression was not correlated with allele loss but seemed to be closely related to the presence of point mutations in this study. No homozygous deletions or rearrangements of the p53 gene were detected. This would argue for an important role of heterozygous p53 mutations in human breast cancer.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract cDNA probe of the casein kinase 2α subunit gene detects a biallelic PstI polymorphism. This restriction fragment length polymorphism is the first known genetic marker of this gene.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1432-5195
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Nous avons eu recours, pour allonger les membres inférieurs, à la méthode d'Ilizarov de distraction épiphysaire depuis 1977 et à sa nouvelle technique de corticotomie ou compactotomie depuis 1983. La première méthode a été utilisée pour 22 membres inférieurs avec un allongement moyen de 8.25 cm (de 4 à 18 cm). Sont inclus dans ce groupe deux achondroplases chez qui les deux membres inférieurs ont été allongés de 12 cm. Dans la deuxième méthode on pratique une corticotomie au niveau de la jonction dia-métaphysaire, suivie d'une distraction avec l'appareil d'Ilizarov (4×0.25 mm par jour). Nous avons allongé 30 membres inférieurs, parmi lesquels 5 patients qui ont eu un allongement bilatéral compris entre 8 et 12 cm. Chez les autres on a obtenu un allongement moyen de 7.9 cm (de 4 à 15 cm). Le rapport entre la durée du traitement par cm obtenu (c'est à dire le temps écoulé entre l'opération et la mise en charge complète divisé par le nombre de cm d'allongement) est plus faible après distraction epiphysaire qu'après corticotomie. Les complications sont également un peu moins fréquentes avec cette dernière technique. La distraction épiphysaire doit être réservée aux enfants, de l'âge de 12 ans jusqu'à la fin de la croissance. L'avantage de la corticotomie est qu'elle peut être effectuée à n'importe quel âge, de 5 à 30 ans. Dans les deux cas, il faut prendre le plus grand soin pour éviter les complications.
    Notes: Summary We have used Ilazorov's method of distraction epiphyseolysis for leg lengthening since 1977 and his new method of corticotomy or compactotomy since 1983. The first method was carried out in 22 lower limbs with an average lengthening of 8.25 cm (range 4 to 18 cm); included in this group are 2 patients with achondroplasia in whom both legs were lengthened 12 cm. In the second method, a corticotomy is carried out at the metaphyseal-diaphyseal junction followed by distraction in Ilazorov's apparatus (4×0.25 mm a day). We lengthened 30 legs; included are 5 patients who had both legs lengthened from between 8 and 12 cm. In the remainder an average of 7.9 cm of lengthening was achieved (range from 4 to 15 cm). The index for the treatment time per cm achieved (time from operation until full weight-bearing per cm of lengthening) was shorter after distraction epiphyseolysis than after corticotomy. Complications were also a little less after the latter procedure. Distraction epiphyseolysis has to be limited to children from aged 12 years until growth ceases. The advantage with corticotomy is that it can be done at any age from 5 to 30 years. Care is needed in both cases to avoid complications.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-2250
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract There has been substantial effort recently put into proving, for a variety of different geometries, the existence of trapped waves, that is unforced time-harmonic motions which do not radiate energy to large distances. Thus it is known that such motions can exist in a deep channel which includes a cylinder spanning the channel, for various shapes of cylinder. The converse problem of proving the absence of such trapped waves has received much less consideration, and the only relevant uniqueness proof for a channel spanned by a cylinder is that of McIver (1991). In an appendix to that paper, McIver demonstrates that no trapped-wave motions can exist for the case in which the cylinder is surface piercing and is entirely contained between vertical planes through the free-surface intersections. This is exactly the same geometrical condition which John (1950) found would ensure uniqueness in water-wave radiation and scattering problems, in finite or infinite depth. Both John and McIver achieved their uniqueness results by consideration of integrals of the potential along vertical lines down from the free surface. John's work was extended by Simon and Ursell (1984) who established uniqueness for a wider class of two-dimensional radiation and scattering problems by consideration of integrals along nonvertical lines. The work presented in this paper is the corresponding extension of McIver's work; although this extension does not rule out trapped waves at all frequencies for any geometry except that already considered by McIver, it does yield an easy lower bound for the ratio of the trapped-mode frequency to the cut-off frequency, in finite or infinite depth.
    Type of Medium: Electronic Resource
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