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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    ISSN: 1432-2218
    Keywords: Fibrin-coated collagen fleece (Tachocomb) ; Endoscopic surgery ; Tachocomb application system
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: Diffuse bleeding from parenchymatous organs or bleeding of the lung both in conventional and endoscopic surgery has to this day been treated with the usual methods — coagulation, tamponade, or oversewing. Methods: With the development by the pharmaceutical industry of a collagen fleece coated with fibrin glue (Tachocomb), an additional method of hemostasis became available. Results: The positive results obtained with the fibrin-coated collagen fleece in conventional surgery encouraged us to employ it when performing endoscopic operations. Especially with laparoscopic cholecystectomies, but also in other endoscopic operations, the application of Tachocomb has proved very successful. Nevertheless, the method of applying Tachocomb was not adequate, and limited its use, which made it necessary for us to develop an application system for endoscopic use. Conclusions: The application system, which consists of a fan as the Tachocomb carrier and a mounting support, worked well during the first tests. In order to confirm this, clinical studies will now be carried out.
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Archives of toxicology 65 (1991), S. 480-484 
    ISSN: 1432-0738
    Keywords: Chloroquine ; Retinopathy ; Retinal pigment epithelium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In order to investigate chloroquine retinopathy, the effect of chloroquine on the viability and differentiation of primary cell cultures of embryonic chick neuronal retina, retinal pigment epithelium (RPE), brain and meninges were investigated. The sensitivity of the cells, measured as reduction of viability, showed the following order: RPE 〉 brain 〉 meninges 〉 neuronal retina. The human serum chloroquine concentration range which leads to ocular damage in vivo was identical to the concentration range in the culture medium which affected RPE viability. In addition, the differentiation of nerve cells in brain cell cultures was affected at much lower chloroquine concentrations than astroglia cells or nerve cells in neuronal retina cell cultures. Some possible mechanisms for chloroquine retinopathy were assessed.
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  • 3
    ISSN: 0949-2925
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
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  • 4
    ISSN: 1612-4766
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Description / Table of Contents: Zusammenfassung In ersten, orientierenden Versuchen wurde die Wirkung des tschechischenBeauveria bassiana-Präparates „Boverol” allein und in Kombination mit Pheromonfallen auf die Mortalität und das Brutverhalten des Buchdruckers,Ips typographus, untersucht. Pathogenitätstests ergaben eine Verpilzungsrate von 88,0 bis 96,7%. Wurden Käfer nach der oberflächlichen Kontamination sofort zur Brutablage an frische, berindete Fichtenstücke gesetzt, so betrug die Reduktion der Brutleistung gegenüber der Kontrolle nur etwa 23 bis 29%. Bei der geschlüpften F1-Generation von kontaminierten Altkäfern konnten keine Unterschiede zu den vergleichbaren Jungkäfern aus der unbehandelten Kontrolle festgestellt werden. Eine Übertragung des Pilzes vom Altkäfer auf den Jungkäfer fand nur in Ausnahmefällen statt. Im Freiland wurde die Wirkung einer Kombination von Pheromonfalle mitB. bassiana getestet, wobei das Einbohrverhalten und die Brutleistung der Käfer in einer darunter eingekäfigten Fichtenrolle überprüft wurden. Die Zahl der Einbohrlöcher war in der BOVEROL-Variante um etwa 15% verringert, die F1-Generation jedoch um nahezu 60%. Mögliche Einsatzstrategien vonBeauveria bassiana mit Hilfe von Pheromonfallen beiIps typographus werden erörtert.
    Notes: Abstract In first, preliminary experiments, the efficacy of the CzechBeauveria bassiana product „Boverol” alone and in combination with pheromone traps on the mortality and the breeding behavior of the bark beetle,Ips typographus, was investigated. Pathogenicity tests resulted in a mortality due to the fungus of 88.0 to 96.7%. When the beetles were given directly after superficial contamination on fresh spruce pieces with bark, the reduction of the breeding efficacy was 23 to 29% compared to the untreated control. No differences between the hatched beetles from the F1-generation of contaminated beetles and those of the untreated control beetles were observed. A transfer of the fungus from the parent beetle to the young beetle was noticed only in a few cases. In the field, the efficacy of a combination of a pheromone trap withB. bassiana was tested. The number of bore holes and the breeding was measured using a caged spruce log. In the combination, the number of bore holes was reduced by 15%, but the F1-generation nearly by 60%. Possible strategies for the use ofB. bassiana in combination with pheromone traps againstIps typographus are discussed.
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  • 5
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
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  • 6
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Measurements of the reversible transverse susceptibility (RTS) were performed on BaFe12−x−yCoxTiyO19 single crystals with doping concentrations x≈y≤0.77 under different angles cursive-theta0 between the easy axis and applied field. For intermediate doping concentrations the occurrence of a peak in the RTS curve for cursive-theta0=90° indicates that the domain walls are not free to move. This assumption is confirmed further by the large component of the RTS being out of phase with respect to the excitation field HE. The phase angle of the initial susceptibility measured parallel to the easy axis becomes maximum at a characteristic excitation field value HE,C and a relaxation of the susceptibility is observed if HE steps from zero to a value larger than HE,C. Using the RTS curve for cursive-theta0=0 and assuming that the peak of the RTS is located at the same field strength as if the particle were single domain, the first-order anisotropy field HA=2K1/(μ0Ms) and the second-order anisotropy constant K2 can be determined. The values found this way are compared to results from magnetization-curve analysis and from other authors.
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  • 7
    ISSN: 0941-1216
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: It has been demonstrated that the methyl and ring C-atoms of methyl-1,3-cyclohexadienes interchange their positions intramolecularly during the thermal conversion to toluene at temperatures above 600°C in a quartz flow system. Gas phase pyrolysis of double 13C-labeled methyl-1,3-cyclohexadienes with 13C-labels for the primary and the tertiary C-atom gave definite 13C-distribution patterns in the aromatic ring systems of the formed toluene as well as benzene with far-reaching similarities. The NMR data of the [13C2]toluene isotopomers definitely rule out that the observed integration of the methyl C-atom into the ring system proceeds via the hitherto well-established sequence: electrocyclic ring opening of the 5-methyl-1,3-cyclohexadiene to 1,3,5-heptatriene, its sigmatropic 1,7-H shift and ensuing recyclization of the 1,3,5-heptatriene to methyl-1,3-cyclohexadienes.
    Additional Material: 1 Ill.
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
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  • 9
    ISSN: 1432-1238
    Keywords: Right ventricular ejection fraction ; Thermodilution ; Fast response thermistor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective To investigate whether determination of right ventricular end-diastolic volume (RVEDV) and right ventricular ejection fraction (RVEF) can be performed with reasonable accuracy and reproducibility using a conventional slow response thermistor pulmonary artery catheter (CPAC) applying an adaptive algorithm. Design To study RVEDV and RVEF simultaneously with pulmonary artery catheters equipped with slow and fast response thermistors (FRPAC) under a broad range of cardiac output. Setting Laboratory of Institute of Experimental Surgery, Technical University. Animals 11 anaesthetised piglets. Interventions Hypovolemia (V−) was induced by withdrawal of blood up to 50 ml/kg, hypervolemia (V+) was produced by retransfusing blood and adding up to 30 ml/kg hydroxyethyl starch. In 5 animals in phases V−and V+ beta-adrenergic stimulation was achieved with dobutamine. Finally pulmonary artery hypertension was induced by infusion of small air bubbles. Measurements and results Cardiac output (CO), RVEDV and RVEF were determined simultaneously with FRPAC and CPAC placed in the same pulmonary artery branch. Measurements were repeated 8 times sequentially in steady state normovolemia. A total of 130 measurements could be analysed. The coefficient of variation was 6.7±4.2 for CO(FRPAC) and 4.6±1.7% for CO(CPAC); for RVEF it was 9.7±6.2% (FRPAC) and 9.9±3.9% (CPAC); for RVEDV it was 11.6±4.8% (FRPAC) and 8.54±3.2 (CPAC). Mean difference (bias) was 0.06±0.39 l/min for CO measured with both methods, 19±35 ml for RVEDV and −3.3±6.5% for RVEF. CO(CPAC) displayed a strong correlation to CO(FRPAC) (R=0.97,p=0.001) as well as RVEF (R for RVEF(CPAC) versus RVEF(FRPAC)=0.90,p=0.001). R for RVEDV(CPAC) versus RVEDV(FRPAC) was 0.67,p=0.001. We conclude that this animal study demonstrates good agreement between RVEF and RVEDV obtained with catheters equipped with a fast response thermistor or with a conventional slow response thermistor allowing accurate monitoring of right ventricular function with a conventional pulmonary artery catheter.
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  • 10
    ISSN: 1432-1963
    Keywords: Schlüsselwörter Magenkarzinom ; Adenokarzinom ; Infiltrativer Typ (Ming) ; Key words Stomach cancer ; Adenocarcinoma ; Infiltrative type (Ming)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Gastric carcinoma of the infiltrative type (according to Ming) occasionally shows adenomatous differentiation only. Over the past 18 years, we have observed 23 cases of this tumour type, accounting for 3.6 % of all surgically treated gastric carcinomas. Macroscopically they were classified as Borrmann IV or III, while histologically most of them were well differentiated. Histologically, these tumours retained the pre-existing structures of the stomach, most readily observable at the tunica muscularis propria; a pronounced desmoplasia was also characteristic, particularly in the submucosal and subserosal layers. In all cases the tumour tissue spread inside lymphatic vessels. All but 2 cases with metastatically involved lymph nodes, often small, showed infiltration of the lymph node sinus; in three quarters of cases the serosa was infiltrated by the tumour. Significant findings among the patients under observation for extended periods included bilateral ovarian metastases in 4 of 5 women examined and tumour recurrence at the anastomosis in 6 of 9 patients in whom Billroth II operation had been performed. The mean survival time of 16 patients was 14.9 months. Owing to the diffuse type of tumour growth, extensive surgery is recommended as in cases of signet ring cell cancer. The high incidence of small lymph node metastases from this type of tumour should also be taken in account at preoperative staging. Preoperative diagnosis of this tumour subtype is difficult, because histological criteria alone do not allow clear identification. Close cooperation with clinical investigators is necessary, and intraoperative assessment of the tumour – including frozen section of necessary – in particular is of the outmost importance.
    Notes: Zusammenfassung Nach Laurén ist das reine Adenokarzinom des Magens immer nur beim intestinalen Typ zu finden, nach Ming können jedoch selten drüsig differenzierte Magenkarzinome ein diffuses Wachstum zeigen. In einem Zeitraum von 17,5 Jahren beobachteten wir 23 Fälle dieses Tumortyps, dies entspricht 3,6 % aller operierter Magenkarzinome. Makroskopisch diese Tumoren vom Typ III oder IV nach Borrmann; histologisch die Tumoren zumeist gut differenziert, über weite Strecken mit Erhaltung der Magenwandstrukturen, speziell an der Tunica muscularis propria erkenntlich. Ebenso charakteristisch eine ausgeprägte Desmoplasie, v. a. in der Submukosa und Subserosa. In allen Fällen bestand eine karzinomatöse Lymphangiose. Alle bis auf 2 Fälle zeigten metastatisch befallene Lymphknoten, oft bei nur geringer Größe lediglich die Lymphknotensinus infiltriert. Etwa 3/4 der Fälle mit einer Serosainfiltration. Bei den länger beobachteten Patienten fanden sich bilaterale Ovarmetastasen in 4 von 5 beobachteten Patientinnen und ein Tumorrezidiv an der Anastomose in 6 von 9 untersuchten Patienten, die magenreseziert wurden. Bei 16 beobachteten Patienten betrug die mittlere Überlebenszeit 14,9 Monate. Wegen dieses diffusen Wachstums wird klinisch ein gleiches operatives Vorgehen wie für das Siegelringzellkarzinom, speziell beim distal gelegenen Magenkarzinom, empfohlen. Klinisch ist beim präoperativen Staging zu beachten, daß bei diesem Tumortyp häufig kleine Lymphknotenmetastasen vorliegen können. Die präoperative Diagnose dieses Tumorentität ist schwierig, da sie allein auf Basis histologischer Merkmale nicht gestellt werden kann, sie erfordert ein gemeinsames Vorgehen mit der Klinik, der intraoperativen Beurteilung des Tumors, evtl. auch im Schnellschnitt, kommt dabei besondere Bedeutung zu.
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