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  • Analytical Chemistry and Spectroscopy  (2)
  • Humans
  • 1990-1994  (2)
  • 1
    ISSN: 0749-1581
    Keywords: Phase-editing ; Relayed responses ; 2D HMQC-TOCSY ; NMR Spectra ; Digoxin ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: An NMR technique for the determination of proton vicinal couplings relayed at the carbon chemical shift is presented. With this technique, which is an extension of DEPT-HMQC-TOCSY, it is possible to generate phaseedited 2D NMR data in which the 1H—13C relayed responses differ in phase as a function of the proton multiplicity of the carbon from whose proton(s) the response originates. A simple pulse scheme is presented to allow further simplification of the spectrum by eliminating the direct 1H—13C correlations. Thus, responses arising from methines or methyls will be of opposite phase from responses originating from methylenes; direct correlations are eliminated to minimize congestion. An example is presented with the cardiac drug digoxin.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 0749-1581
    Keywords: NMR ; Region-selective inverse detected long-range heteronuclear chemical shift correlation ; Shaped pulses ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: F1 region-selected variants of the HMBC experiment were compared and evaluated. In particular, a significant advantage was demonstrated for an E-BURP-2 pulse over a Gaussian 270° pulse for region-selected applications. The Gaussian 270° pulse would still, however, be the preferred pulse for use in single-resonance, on-resonance selective excitation. Data are presented from NMR spectrometers both equipped and not equipped with programmable pulse modulators (waveform generators). Pulse evaluations were performed using the simple heteroaromatic alkaloid quindoline; application of the technique to the important immunosuppressive cyclic peptide cyclosporin-A is also presented and discussed.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
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