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  • 1990-1994  (121)
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  • 1
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Seven fragments of the spike (S) gene cDNA of transmissible gastroenteritis virus (TGEV), as well as the full length cDNA, were cloned and expressed in baculovirus vectors. Piglets were immunized with cells infected with the recombinant viruses. Each of the recombinants induced TGEV-specific antibodies detected in a fixed cell enzyme immunoassay. The amino terminal half of the S protein, containing all four major antigenic sites (A, B, C and D), and encoded by a 2.2 kb fragment of the S gene, induced virus neutralizing (VN) antibody titers comparable with those induced by the complete S protein. Recombinant proteins lacking the A antigenic site, or with a deletion including the putative receptor binding sites and the D antigenic site, were not capable of inducing levels of VN antibodies similar to those induced by the whole S protein.
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  • 3
    ISSN: 1432-2161
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    World journal of surgery 14 (1990), S. 128-132 
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Nous avons analysé notre expérience des abcès hépatiques pyogènes pour déterminer l'influence du drainage percutané et de la durée de l'antibiothérapie sur les résultats du traitement. On observait un mauvais pronostic chez les patients ayant eu un choc, un syndrome de détresse respiratoire de l'adulte, une coagulopathie vasculaire disséminée, un ictère, une hypoalbuminémie et/ou un diabète. Le drainage percutané a été utilisé avec succès chez 4 des 6 patients mais n'a influencé ni la mortalité ni la durée d'hospitalisation. Le drainage percutané a été le procédé de choix chez un groupe de patients sélectionnés. La moitié des patients avaient reçu des antibiotiques 2 semaines ou moins sans récidive. Une utilisation prolongée des antibiotiques n'est pas nécessaire si l'abcès a été correctement drainé chirurgicalement ou par voie percutanée.
    Abstract: Resumen Se revisó la experiencia con treinta y cuatro pacientes con absceso piogénico del hígado con el fin de evaluar el impacto del drenaje percutáneo y la duración de la terapia antibiótica sobre los resultados del tratamiento. Los pacientes con shock, síndrome de dificultad respiratoria del adulto, coagulación diseminada intravascular, ictericia, hipoalbuminemia severa, y diabetes exhibieron un mal pronóstico. El drenaje percutáneo fue utilizado exitosamente en 4 de 6 pacientes pero su uso no modificó la tasa de mortalidad ni la duración de la hospitalización. El drenaje percutáneo puede ser el procedimiento de elecctión en casos seleccionados. La mitad de nuestros pacientes recibió antibióticos por 2 semanas o menos, sin que se presentara recurrencia del absceso. La antibioticoterapia a largo plazo puede ser innecesaria una vez realizado un adecuado drenaje, quirúrgico o percutáneo, del absceso.
    Notes: Abstract Experience with 34 patients with pyogenic liver abscess is reviewed to evaluate the impact of percutaneous drainage and duration of antibiotic therapy on results of treatment. Patients with shock, adult respiratory distress syndrome, disseminated intravascular coagulation, jaundice, severe hypoalbuminemia, and diabetes had a poor prognosis. Percutaneous drainage was used successfully in 4 of 6 patients, but its use did not affect mortality rate or length of hospital stay. Percutaneous drainage may be the procedure of choice for selected patients. Half of our patients received antibiotics for 2 weeks or less with no abscess recurrences in this group. Long-term antibiotics may not be necessary after adequate surgical or percutaneous abscess drainage.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-0614
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract Because of the diversity of their lipids and fatty acid biosynthetic pathways, lower fungi may find utilization as sources of omega-3 or other polyunsaturated fatty acids (PUFA). Production of eicosapentaenoic acid (EPA) by the filamentous fungus, Pythium irregulare, has been demonstrated in 14-1 fermentors. Sweet whey permeate (lactose) was preferred over glucose as a substrate for production of a high-EPA-content lipid. Characterization of the lipid indicated that approximately 90% of the EPA was contained in the neutral lipid fraction. A specific productivity of 24.9 mg EPA/g dry biomass was achieved at 14°C, at which temperature the lipid contained 25.5% EPA and 54.2% PUFA. This is the highest mycelial EPA content for a fungal lipid that has been reported in the literature.
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  • 6
    ISSN: 1432-0703
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Notes: Abstract The distributions of polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs) measured in surficial sediments from the lower Passaic River and Newark Bay, New Jersey, USA, were compared to those reported in various industrial process residues and effluents, contaminated soils, chemical formulations, and municipal waste disposal activities that are known or suspected to be sources of these compounds in the aquatic environment. Comparisons were conducted using data from published literature to determine whether the composition of tetra through octachlorinated congeners and 2,3,7,8-substituted residues reported in a broad range of potential environmental sources could explain the presence of these compounds in Newark Bay. Pattern similarities and differences between congener groups and isomers were obtained by principal components analysis. The congener and isomer fingerprint patterns found in surficial sediments appear to be the result of releases from several industrial and municipal sources commonly found in heavily industrialized and populated urban environments, including municipal sewage sludge, municipal solid waste incinerator fly ash, pentachlorophenol, sodium pentachlorophenate, newsprint, scrap metal reclamation incinerators, combustion engines, and pulp and paper mill black liquor recovery furnaces. The variations among the PCDD and PCDF residue and congener patterns were largely explained by the distributions of the hexa- and octachlorinated compounds and by 2,3,7,8,-TCDD, 2,3,7,8,-TCDF, and the penta-substituted isomers. Although it has been claimed that a single industrial source is responsible for the presence of these compounds in the sediments of Newark Bay, the available evidence indicates that the vast majority of the PCDDs and PCDFs are the result of contributions from several industries. There is no evidence from this analysis to indicate that a single source is responsible for the contamination.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-0703
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Notes: Abstract The distributions of 2,3,7,8-substituted polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs) measured in surficial sediments from the lower Passaic River and Newark Bay, New Jersey were compared to those observed in sediments from other waterways located within industrial or heavily populated areas using chemometric techniques. Comparisons were conducted using published data to determine whether the distributions of 2,3,7,8-substituted isomers in surficial sediments from industrialized waterways have similar or different fingerprint patterns. Chemometric evaluations consisted of principal components analysis and the complete linkage: farthest neighbor cluster method. The concentrations of individual isomers were normalized to the combined sum of the 2,3,7,8-substituted PCDD and PCDF isomer concentrations in order to evaluate relative distribution patterns. Several of the isomeric fingerprint patterns found in sediments from the lower Passaic River and Newark Bay were similar to those found in sediments from New Bedford Harbor, MA, USA, Black Rock Harbor, CT, USA, Providence River, RI, USA, Eagle Harbor, WA, USA, the Inner Stockholm archipelago, Sweden, Hamburg Harbor, Germany, and St. Laurensharbor, The Netherlands. Pattern differences were observed in sediments from Frierfjorden, Norway, Niagara River, NY, USA, and Chemieharbor, The Netherlands. The variations among the 2,3,7,8-substituted isomer patterns observed in different sediments were largely explained by the distributions of the higher chlorinated isomers. Other differences may be attributed to environmental conditions unique to each waterway such as tidal flux, shipping traffic, urbanization, sedimentation rates, and the presence of different industrial sources. Similarities in PCDD and PCDF patterns among the waterways were related to the presence of similar municipal and industrial sources, including effluents from pentachlorophenol and polychlorinated biphenyl manufacturing facilities, pulp and paper mills, automobile and shipping traffic, and municipal solid waste and industrial incinerators. The distributions of PCDDs and PCDFs in surficial sediments from some areas of the Newark Bay estuary were representative of those found in many industrialized regions. It wsa evident from this analysis that the application of chemometric analysis can be useful in characterizing the distribution of complex multi-constituent chemical residues and identifying sources of these compounds in freshwater, estuarine, and marine sediments.
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  • 8
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 362 (1993), S. 14-15 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] in Alzheimer's disease, distinctive extraá-cellular plaques which are principally composed of an aggregated peptide, {$-amyloid, accumulate in parts of the brain involved in memory and cognition. Much attention has been paid to the possibility that the plaques may be an early and critical ...
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  • 9
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The presence of a consensus sequence known to mediate clathrin coated pit internalization in the /8 APP carboxyl terminus (Asn-Pro-Thr-Tyr, amino acids 759-762) indicates that /3APP could be reinternalized from the cell surface like a variety of receptors7. To investigate this possibility, we ...
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  • 10
    ISSN: 1573-904X
    Keywords: bioavailability ; flurbiprofen ; buccal administration ; periodontal disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The buccal absorption of flurbiprofen was evaluated in nine normal volunteers. Twenty milliliters of 2.5 mg/ml flurbiprofen solution (pH 8.03) was administered as a 1-min mouthwash or a 5-min mouthwash or swallowed. Serum was harvested from blood samples taken at specified times over a 12-hr period. Serum flurbiprofen concentration data indicate that the extent, but not the rate, of drug absorption was dependent upon the time of exposure of the flurbiprofen solution to the buccal membrane. Following the 1- and 5-min mouthwash treatments, 5.2 and 9.4% of the administered doses were absorbed, respectively.
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