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  • 1
    ISSN: 1432-1041
    Keywords: Sulphadimidine ; Acetylation phenotype ; Turkish Population
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The distribution of acetylator phenotypes was studied in 244 unrelated Turkish subjects. Sulphadimidine and its acetylated metabolite were measured in 6 h plasma and 0–6 h urine samples after an oral dose of 10 mg/kg. Subjects with 37.5% or less acetylsulphadimidine in plasma were regarded as slow acetylators and the others as rapid acetylators. The mean plasma concentration of acetylsulphadimidine was about 2.5-times lower in slow acetylators. Urinary excretion of total sulphadimidine (free + acetylated) was also significantly lower in slow acetylators compared to rapid acetylators. The frequency of slow acetylators was 60.7% in the population (95% confidence interval 54.3% to 66.8%). Sulphadimidine acetylation showed no variation due to sex, age, body weight or pre-existing disease.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 0886-1544
    Keywords: motility ; flagellum ; spermatozoon ; nexin ; freeze-etch ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: In this work, we examine whether the “nexin” linkages of the flagellum can extend in length to accommodate interdoublet sliding. Flagellar bends of large angle were induced in bull spermatozoa by hypotonic treatment. It is argued that this produces large interdoublet displacements that are, nevertheless, still within physiological limits. Such flagella were examined by the rapid-freeze, deep-etch techique and the nexin linkages identified by their position in relation to the inner dynein arms and by their straplike, bipartite, morphology. They were found to bridge perpendicularly (or occasionally at an angle) between the A- and B-tubules of adjacent doublets. The nexin linkages were no more than ∼20 nm in length, even in regions in which ∼200 nm of sliding could be inferred. Variable registration between adjacent nexin rows gave some further support to the assumption that sliding had indeed taken place. From this, it is concluded that elastic deformation of the links, such as would accommodate interdoublet sliding, does not occur; some form of displacement must occur between nexin and the adjacent B-tubule. © 1993 Wiley-Liss, Inc.
    Additional Material: 12 Ill.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    ISSN: 1365-4632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Behçet's Disease (BD) is a systemic disorder with an unknown etiopathogenesis. The need for clinical criteria in the establishment of diagnosis is of great importance. We present the case of a 27-year-old man with BD, who had a surgical operation during the active period of his disease and experienced subsequent complications. Cutaneous hyper-reactivity response to minor cutaneous trauma—the pathergy phenomenon— is found in most patients with BD. Theoretically, major traumas may lead to major reactions in the skin or any of the organs. In practice, we observed that while there was a severe inflammatory reaction — histopathologically a superficial perivascular dermatitis—which developed at the incision site, the systemic symptoms of the disease increased in spite of intensive treatment of the condition.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1573-1111
    Keywords: Inclusion complexation of warfarin withβ-CDs ; apparent binding constants ; bioavailability of warfarin ; β-CD complexes ; fluorescence spectroscopy ; β-cyclodextrin ; 2-hydroxypropyl-β-cyclodextrin ; methyl-β-cyclodextrin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The inclusion complexes of warfarin withβ-cyclodextrin, 2-hydroxypropyl-β-CD and methyl-β-CD have been investigated in aqueous solution. The apparent binding constants of warfarin are found to be 542±19, 442±18 and 112±6M−1 respectively, calculated from the increments in fluorescence emission of the drug. The influence of theβ-CDs on the absorption rate of the drug is investigated within situ experiments in a chronically isolated internal loop, in the small intestine of the rat. The first-order disappearance (absorption) rate constant decreases to 3.6×10−4 min−1 inβ-CD, to 5.0×10−4 min−1 in 2-hydroxypropyl-β-CD and to 1.4×10−3 min−1 in methyl-β-CD compared to 3.2×10−3 min−1 in isotonic phosphate buffer (pH=7.4) solution, all of them showing a good agreement with the percentage of free warfarin in their complexed solutions: 16%, 18% and 47% calculated, respectively.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Digestive diseases and sciences 37 (1992), S. 1127-1130 
    ISSN: 1573-2568
    Keywords: Crohn's disease ; extraintestinal manifestation ; granulomatous tonsillitis ; oral lesion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Oral lesions, varying in nature and location, appear to be one of the common extraintestinal manifestation of Crohn's disease. In particular, oral involvement preceding intestinal disease may lead to the diagnosis of Crohn's disease. The present case report of a 17-year-old male patient describes a very rare nonintestinal manifestation of Crohn's disease with severe granulomatous involvement of the tonsils. A sore throat caused by hyperplastic tonsils with granulomatous inflammation as an oral manifestation of Crohn's disease was the leading symptom in this case.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: A variable mass, cylindrical plasma model (VMCPM) is developed for sparks created by electrical discharge in a liquid media. The model consist of three differential equations—one each from fluid dynamics, an energy balance, and the radiation equation—combined with a plasma equation of state. A thermophysical property subroutine allows realistic estimation of plasma enthalpy, mass density, and particle fractions by inclusion of the heats of dissociation and ionization for a plasma created from deionized water. Problems with the zero-time boundary conditions are overcome by an electron balance procedure. Numerical solution of the model provides plasma radius, temperature, pressure, and mass as a function of pulse time for fixed current, electrode gap, and power fraction remaining in the plasma. Moderately high temperatures ((approximately-greater-than)5000 K) and pressures ((approximately-greater-than)4 bar) persist in the sparks even after long pulse times (to ∼500 μs). Quantitative proof that superheating is the dominant mechanism for electrical discharge machining (EDM) erosion is thus provided for the first time. Some quantitative inconsistencies developed between our (1) cathode, (2) anode, and (3) plasma models (this series) are discussed with indication as to how they will be rectified in a fourth article to follow shortly in this journal. While containing oversimplifications, these three models are believed to contain the respective dominant physics of the EDM process but need be brought into numerical consistency for each time increment of the numerical solution.
    Type of Medium: Electronic Resource
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