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  • 1
    ISSN: 1432-1076
    Keywords: Tuberculosis ; Child ; Contact tracing ; Migrants ; Antitubercular agents
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The incidence of tuberculosis (TB) presenting to the University Hospital, Geneva, Switzerland, was studied over 2 years. Clinical data on all children receiving antituberculous drug therapy was collected. Of the 43 identified cases, 42% had active disease (i.e. clinical evidence of organ involvement), the remaining 58% being asymptomatic. All 43 children originated from countries other than Switzerland. Symptomatic, drug induced hepatitis necessitated temporary interruption of therapy in 2 children (5%). Contact screening yielded three new cases of pulmonary TB, three previously diagnosed cases and seven instances of a positive medical history in relatives living in other countries. Of the 34 families in this study, contact screening could not be completed in 8. The results of this study indicate that children with TB are primarily associated with families originating from countries other than Switzerland, particularly those in which TB remains endemic. Tuberculin skin testing should therefore be targeted at this group. Contact tracing has also been shown to be beneficial.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1420-9071
    Keywords: Hypertension ; infancy ; genetic strains ; environmental contributions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Cardiovascular responses of adult organisms to feeding are well characterized and, in general, are understood as acute adaptations required for processing and distributing nutrients. Research over the past several years has shown that infants also have important cardiovascular responses to nutrient intake and that these are regulated by changes in autonomic activity to the heart and vasculature. Recent studies have provided results that suggest these responses in infancy may make an important contribution to the long-term development of cardiovascular function, in particular, adult blood pressure (BP). The purpose of this presentation will be to review the evidence that has led to this conclusion, offer ideas about how this potential early-life shaping of subsequent cardiovascular function may come about, and suggest further studies that will be required in order to characterize the mechanisms responsible for these effects.
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  • 3
    ISSN: 1420-9071
    Keywords: Dipyridamole ; adenosine monophosphate ; cell proliferation ; hemopoiesis ; gamma-irradiation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Combined treatment with dipyridamole and adenosine monophosphate enhances cell proliferation in the hemopoietic tissue of normal and gamma-irradiated mice. This effect can be explained by the elevation of extracellular adenosine, and the receptor-mediated activation of the cell adenylate cyclase system.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1420-9055
    Keywords: Biogenic stagnation ; vertical mixing ; tritium-helium age ; double diffusion ; boundary mixing ; deep lakes ; Lake Lugano (Lago di Lugano)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Long-term stratification of the deep hypolimnetic waters of the northern basin of Lake Lugano (Lago di Lugano) has resulted in a lack of deep-water renewal which has persisted for decades. Tritium-helium age measurements reveal that deep water has not been in contact with the atmosphere since the 1960s. Higher primary production associated with the significant increase in phosphorus concentration which occurred at this time resulted in greater autochthonous gross sedimentation rates, increasing the rate of mineralization and, consequently, the rate of release of dissolved solids (mainly HCO 3 - and Ca2+) into the deep hypolimnion. This gave rise to an intensification of the stratification and to a consequent reduction in the vertical exchange of hypolimnetic water layers. Today, the density stabilizing effect of ion release due to mineralization in the deep water is four to five times greater than the destabilizing effect of the geothermal heat flux from the earth's interior. It is known from laboratory experiments that such small density gradient ratios are likely to give rise to double-diffusive instabilities. However, even rudimentary mass balance calculations of biogeochemical components indicate that shear-induced turbulence, most likely generated by bottom currents, mixes far more efficiently than double diffusion. In the future, the biogenic density stratification is likely to persist in the deep water, unless the upward ion flux, driven by primary production, decreases by a factor of four to five.
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  • 5
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 61 (1990), S. 306-308 
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: The main features of ECR ion sources (high efficiency, almost unlimited lifetime, stable running conditions, low ion energy spread) make them, when optimized for a high yield at charge state 1+, ideally suited for on-line mass separation. For this reason a single stage 6.4 GHz test source was built for the Paul Scherrer Institute medical radioisotope production facility. Source geometry and operation conditions were optimized for the mass separation of xenon isotopes. Different support gases were tested and an ionization efficiency of 60% for Xe+ was achieved with H2 as support gas. The best results were found at a source pressure of 5×10−4 mbar and at a microwave power level of about 100 W. At an axial magnetic field of about 3 kG the mirror ratio showed no strong effect on the general performance of the source. Our tests showed the advantages of the ECR source type for the mass separation of gaseous isotopes in terms of efficiency and reliability.
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  • 6
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Copenhagen : International Union of Crystallography (IUCr)
    Applied crystallography online 24 (1991), S. 832-835 
    ISSN: 1600-5767
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Geosciences , Physics
    Notes: Heavy sonication of lipid IVA in different buffer solutions at pH values around 7.4 produces mostly unilamellar vesicles, which are stable over several weeks. For short sonication times these vesicles are very large, about 250 nm in terms of an average hydrodynamic radius with slight polydispersity, as determined by quasi-elastic light scattering. Therefore, small-angle X-ray scattering curves obtained with a conventional instrument do not contain enough information to determine the overall size of the lipid IVA aggregates. However, the pair distance distribution function (PDDF) of the scattering curve is in agreement with the assumption of large vesicular particles. The thickness of the double layer is very small compared to the overall diameter. It can be evaluated assuming a lamellar particle. The corresponding PDDF provides a thickness of about 5 nm. The electron density distribution within the double layer can be calculated directly from the PDDF by a convolution square-root operation. Head groups and hydrocarbon chains are represented by two regions of different electron densities.
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