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  • 1990-1994  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Transplant international 5 (1992), S. 125-128 
    ISSN: 1432-2277
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Conclusion Although liver transplantation still cannot be considered as a routine therapy, the initial phase of development has now been reached and results are encouraging. The benefits to the patient from the liver transplant “revolution” are clear, since it represents the only therapeutic option for patients with advanced liver disease. In return, it has brought unexpected problems to the fore. A vast increase in potential candidates is now confronting the transplant teams, bringing the problem of organ shortage and with it the need to clarify selection and timing in order to avoid potential organ wastage in “hopeless” cases. Since more than three-quarters of transplant patients will make a complete medical recovery, the long-term effects of immunosuppression and quality of life become all-important. Our goal now must be effective utilisation of all potential livers and further improvement of results in critical groups of candidates.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1573-904X
    Keywords: lidocaine ; conformations ; infrared (IR) ; nuclear magnetic resonance (NMR) ; hydrogen bonding ; partition coefficients
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract IR and 1H NMR studies in CDCl3 and CCl4 of a series of tertiary aminoxylidides with the amino group in the 2 to 6 position of the acyl chain are described. Lidocaine, diethylaminoaceto-2′,6′-xylidide, forms an intramolecular five-membered ring hydrogen-bonded monomer at all concentrations in both solvents. β-Diethyl-amino-propiono-2′,6′-xylidide forms an intramolecular six-membered ring hydrogen-bonded monomer in CDCl3 and CCl4 but a trans intermolecularly associated species is the major form present at high concentrations in CCl4. The longer-chain homologues are mixtures of nonassociated trans and cis monomers at low concentrations but associated trans forms predominate at high concentrations. Evidence for the presence of a hydrogen-bonded seven-membered ring intramolecular monomer in CDCl3 for γ-diethylaminobutyro-2′,6′-xylidide is presented. The relationship between the molecular conformation and the partition coefficient is discussed.
    Type of Medium: Electronic Resource
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