Crystallography Journals Online : IUCR Backfile Archive 1948-2001
Chemistry and Pharmacology
The packing of glutathione reductase from Escherichia coli in crystal form T showed a place where two molecules are at a distance of only 6 Å between the closest atoms, i.e. where a contact is almost made. In order to form this contact with hydrogen bonds, two amino-acid residues were exchanged. This mutation had no effect on molecular packing or the resolution limit of the X-ray diffraction, but facilitated crystal nucleation dramatically and possibly increased the crystal growth rate and shortened the crystallization time.
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