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  • 1990-1994  (22)
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  • 1
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We have examined the effect of a range of histamine H1- and H2-receptor agonists and antagonists on rat peritoneal mast cells. Most of the compounds had a dual action: at low concentrations they inhibited the histamine release produced by immunologic activation of the cell whereas, at higher concentrations they themselves induced a cytotoxic release of the amine. The test agents did not affect intracellular levels of cyclic AMP. In model systems the majority of the drugs had no effect, on the intergrity of artificial liposomes but did protect rat erythrocytes against osmotic shock. We then propose that these agents produce their effects on mast cells by a direct action on the cell membrane, with low concentrations becoming incorporated into the bilayer in such a way as to stabilize the structure and high concentrations disrupting the membrane and leading to cell lysis.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Inflammation research 30 (1990), S. 67-69 
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Bradykinin and a range of peptide analogues induced a dose-dependent release of histamine from rat peritoneal mast cells. The characteristics of the release were not consistent with the involvement of defined bradykinin receptors but indicated that the peptide acted through the putative mast cell polyamine receptor. Consistently, the effect of bradykinin was largely confined to serosal mast cells of the rat and hamster, while human histaminocytes were essentially unresponsive. These data do then not support a general role for kinin-induced activation of mast cells in human allergic disease.
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Inflammation research 33 (1991), S. 3-3 
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Inflammation research 33 (1991), S. 4-7 
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Conclusion It is now some eighty years since the pioneering studies of Dale, Barger, Laidlaw and others defined the immediate pharmacological actions of histamine. In that period, it has become apparent that endogenous histamine is implicated in a diversity of physiological processes as well as in immediate hypersensitivity reactions and injury. Thus, the amine is intimately involved in the control of gastric acid secretion, acts as a neurotransmitter or modulator in the brain, and influences cell growth and immune function. The definition of distinct receptor subtypes for the autacoid has found therapeutic application in the treatment of allergy and peptic ulcer disease and holds promise for the management of problems of sleep and wakefulness. Indeed, the discovery of H2-receptors, and more recently H3-receptors, has led to a considerable resurgence in interest in histamine in biology and clinical medicine. It is hoped that this interest will continue and prosper.
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  • 5
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Rat peritoneal mast cells (RPMC) purified through Percoll and a commercially available 35% bovine serum albumin (BSA) solution (Path-O-Cyte 4) are compared over a range of criteria with mixed peritoneal cell suspensions. Both the purity and spontaneous histamine release were slightly better in RPMC isolated through Percoll and histamine recovery was considerably greater using this method as opposed to Path-O-Cyte 4. The responsitivity of cells isolated by either method to compound 48/80 and ionomycin was comparable with that seen in non-purified RPMC. However, the histamine release induced by anti-rat IgE and concanavalin A was reduced in the purified cells especially in those isolated through BSA. Histamine release induced by IgE-directed ligands was potently inhibited by theophylline, isobutyl methyl xanthine, disodium cromoglycate and nedocromil sodium in both non-purified and Percoll-purified RPMC. In total, this study has shown that highly purified and viable RPMC can be obtained through Percoll purification. This method was seen to be generally superior to that of Path-O-Cyte 4.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Mast cells isolated from human colon and stomach released histamine on challenge with anti-human IgE. Sulphasalazine (1 nM−100 μM) had no effect on the secretion induced by optimal concentration of anti-IgE but potentiated the release evoked by sub-maximal amounts of the ligand. Over the same concentration range, sulphapyridine had no effect on the release. However, 5-aminosalicylic acid (5-ASA) produced a dose-dependent inhibition of secretion with an IC50 ofca 50 μM. These results are discussed in terms of the possible therapeutic action of sulphasalazine.
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  • 7
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of furosemide and bumetanide on immunologically stimulated rat peritoneal and human lung mast cells were compared. Furosemide and bumetanide had different modulatory actions on the rat peritoneal mast cell. Furosemide inhibited anti-IgE-induced histamine release. Preincubation of the cells with the drug, prior to anti-IgE stimulation, significantly reduced furosemide's inhibitory effect. In contrast, bumetanide potentiated anti-IgE-induced histamine secretion from the rat peritoneal mast cell. Both diuretics were modest inhibitors of anti-IgE-mediated histamine release from human lung mast cells. For furosemide, inhibition decreased with preincubation, while preincubation increased bumetanide's inhibitory action.
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  • 8
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In order to examine the role of mast cells in the inflammatory bladder disease interstitial cystitis, mast cells isolated from the human bladder of normal and diseased tissue were challenged with a range of secretagogues. Calcium ionophore A23187 and anti-IgE caused histamine release from all bladder mast cells in a dose-related manner. Mast cells from the diseased tissue were far more responsive than those from the normal tissue. Mast cells from the muscle of normal bladder were responsive towards substance P and compound 48/80. However, mast cells from interstitial cystitis bladder did not release significant amounts of histamine with these two secretagogues.
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  • 9
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Extracellular adenosine 5′-triphosphate (ATP) induced a characteristic, dose-dependent release of histamine and prostaglandin D2 (PGD2) from rat peritoneal mast cells. The process was relatively slow, non-cytotoxic, maximal at physiological pH and dependent on external calcium. Strontium and barium ions were able to substitute for calcium, although higher concentrations were required for maximal release. Cells stimulated in the absence of calcium progressively lost the ability to respond to subsequent reintroduction of the cation. The secretion of histamine induced by ATP was largely unaffected by the anti-asthmatic drugs disodium cromoglycate and nedocromil sodium but was inhibited by structurally related flavonoids and by cAMP-active drugs. Importantly, the non-hydrolysable guanosine 5′-triphosphate (GTP) analogue, GTP-γ-S, elicited a dose-dependent release of histamine when introduced into mast cells permeabilized with ATP in the absence of external calcium. ATP thus appears to be a useful cell permeabilizing tool with which to study the biochemical processes involved in mast cell activation.
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  • 10
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Mast cells isolated from human gastric mucosa released histamine on challenge with IgE-directed ligands and calcium ionophores but were esentially unresponsive to a variety of non-immunological stimuli. Moreover, immunologically induced histamine secretion from these cells was inhibited by a number of anti-allergic agents including anti-asthmatic chromones, β-adrenoceptor agonists and phosphodiesterase inhibitors. In total, these data indicate that mast cells from the human gastric mucosa are in many respects functionally similar to their lung and colonic counterparts.
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