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  • 1990-1994  (2)
  • 1
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract A method is presented for the determination of urine folates by a commercial radio-proteinbinding assay widely used in clinical diagnostics for assessing plasma folate levels. Good recovery of urine folates over the range of the calibration curve was observed. Because of the speed, sensitivity and precision of this test, urine folate levels can be measured in bioavailability studies or for the assessment of folate status.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1573-2568
    Keywords: indomethacin ; diclofenac ; piroxicam ; ulcer ; zinc acexamate ; stomach ; scanning electron microscopy ; ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The gastroprotective effect of zinc acexamate against gastric damage induced by different nonsteroidal antiinflammatory drugs (indomethacin, diclofenac, and piroxicam) was morphologically assessed in the rat glandular stomach by light and scanning electron microscopy. In addition, the capability of these antiinflammatory drugs to inhibit gastric prostaglandin E2 production was compared with their ability to induce gastric lesions. Microscopically, disappearance of mucus glycoprotein and exfoliation of the mucosal surface were the most common findings. Surface ultrastructural lesions varied from minimal lesions of the surface epithelial cells to deep erosions of the gastric mucosa with release of associated cellular elements and sloughing of the denuded lamina propria. Diclofenac elicited the most powerful inhibitory activity on mucosal prostaglandin E2 (98% inhibition vs control), closely followed by piroxicam (97.8%) and indomethacin (91.05%). Pretreatment of animals with zinc acexamate significantly increased the presence of mucus glycoprotein, maintained the continuity of the surface epithelial cells, and decreased the depth of the mucosal erosions. The degree of protection exerted by zinc acexamate varied with the antiinflammatory, but was always evident.
    Type of Medium: Electronic Resource
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