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  • 1990-1994  (2)
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  • 1
    ISSN: 1432-1351
    Keywords: Hearing ; Chiroptera ; Desmodus Inferior colliculus ; Tonotopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary 1. Within the tonotopic organization of the inferior colliculus two frequency ranges are well represented: a frequency range within that of the echolocation signals from 50 to 100 kHz, and a frequency band below that of the echolocation sounds, from 10 to 35 kHz. The frequency range between these two bands, from about 40 to 50 kHz is distinctly underrepresented (Fig. 3B). 2. Units with BFs in the lower frequency range (10–25 kHz) were most sensitive with thresholds of -5 to -11 dB SPL, and units with BFs within the frequency range of the echolocation signals had minimal thresholds around 0 dB SPL (Fig. 1). 3. In the medial part of the rostral inferior colliculus units were encountered which preferentially or exclusively responded to noise stimuli. — Seven neurons were found which were only excited by human breathing noises and not by pure tones, frequency modulated signals or various noise bands. These neurons were considered as a subspeciality of the larger sample of noise-sensitive neurons. — The maximal auditory sensitivity in the frequency range below that of echolocation, and the conspicuous existence of noise and breathing-noise sensitive units in the inferior colliculus are discussed in context with the foraging behavior of vampire bats.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Ziel dieser Studie war es, die Konzentrationen von Ciprofloxacin im menschlichen Bauchspeicheldrüsengewebe und -saft zu ermitteln. Die von uns mittels Hochdruck-Flüssigkeitschromatographie (HPLC) ermittelte Konzentration betrug sowohl in menschlichem Pankreasgewebe wie auch im Pankreassaft im Median 0,9 mg/kg (mg/l) 140 min (Median) nach Beginn der intravenösen Kurzinfusion (30 min) von 200 mg Ciprofloxacin. Das Verhältnis der Gewebekonzentration zur zeitgleich vorhandenen Serumkonzentration betrug im Median für Pankreasgewebe 1,0 und für Pankreassaft 0,83. Im Vergleich mit den publizierten minimalen Hemmkonzentrationen für die relevanten Bakterien zeigt sich, daß Ciprofloxacin aufgrund seiner pharmakokinetischen Daten im Pankreas zur Behandlung septischer Komplikationen der akuten Pankreatitis geeignet erscheint. Allerdings sind weitere klinische Studien notwendig, um diese Vermutung zu beweisen.
    Notes: Summary The aim of this study was to determine the concentrations of ciprofloxacin in human pancreatic tissue and juice. Concentrations were measured by high-pressure liquid chromatography (HPLC). Two hundred mg of ciprofloxacin were administered as a short i. v. infusion (30 min). The median ciprofloxacin concentrations 140 min (median) after the start of infusion in pancreatic tissue as well as in pancreatic juice were 0.9 mg/kg (mg/l). The penetration ratio was 1.0 for pancreatic tissue and 0.83 for pancreatic juice. With regard to the minimal inhibitory concentrations (MIC) for the respective bacteria, ciprofloxacin seems to be an appropriate drug for the treatment of septic complications in necrotizing pancreatitis. Future clinical trials are necessary to prove this assumption.
    Type of Medium: Electronic Resource
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