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  • Articles  (103)
  • 2015-2019  (11)
  • 1985-1989  (92)
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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    World journal of surgery 10 (1986), S. 269-280 
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé L'irradiation est employée couramment pour traiter d'emblée ou secondairement les tumeurs pelviennes. Bien que les complications aiguËs intéressant les régions irradiées aient été éliminées grâce à l'amélioration technique de l'irradiation, les complications tardives persistent sous la forme de lésions pelviennes et périnéales complexes. En raison d'une altération de la vascularisation locale secondaire à une endartérite oblitérante, le traitement de ces lésions échoue souvent et se traduit par une infection secondaire ou par une cicatrisation difficile. Vingt-quatre malades présentant des lésions radiques pelviennes ont été traités avec succes par des lambeaux musculaires, musculocutanés ou fascio-cutanés. Leur étude permet d'exposer la base physiologique de la réparation par lambeaux vasculaires. Le choix du lambeau spécifique dépend de la localisation de la lésion: région antérieure du pelvis, région inguinale, périnée, cavité pelvienne et sacrum. Les lambeaux vascularisés doivent posséder un pédicule vasculaire provenant d'une région qui n'a pas été irradiée. Les lambeaux qui conviennent peuvent provenir de la partie antérieure de la paroi abdominale, de la région antérieure ou postérieure de la cuisse, de la région pelvienne postérieure et doivent posseder un arc de rotation permettant de couvrir les zones victimes de l'irradiaion. En conclusion l'exérèse de la région irradiée suivie du recouvrement du défect pariétal par un lambeau bien vascularisé est une méthode réparatrice utile et fiable pour traiter les lésions nécrotiques postradiques du pelvis et du périnée.
    Abstract: Resumen La radioterapia se utiliza en la actualidad como modalidad de manejo primario o adyuvante de tumores pélvicos. Aunque los avances en las técnicas de irradiation han eliminado casi por completo las complicaciones agudas sobre el campo irradiado, todavía se presentan complicaciones tardías en la herida, las cuales resultan en heridas crónicas de alta complejidad en la pelvis y el periné. Puesto que tales heridas son un reflejo de alteraciones circulatorias locales secundarias a endarteritis obliterativa, su manejo local con frecuencia falla en lo que se refiere al control de la infección secundaria o al logro de la cicatrización espontánea. Veinticuatro pacientes con heridas perineales crónicas han sido sometidos recientemente a exitosa reparación mediante el uso de mÚsculo y de colgajos musculocutáneos y fasciocutáneos. La revisión de estos pacientes demuestra las bases fisiológicas para el uso de colgajos vascularizados en el cierre de estas heridas. La selección de colgajos específicos se fundamenta en la localización de la herida pélvica de irradiación sobre la pelvis anterior y la región inguinal, el periné y la cavidad pélvica, y el sacro. Colgajos bien vascularizados deben poseer una fuente independiente de circulación ubicada lejos del lugar de la lesión por irradiación, si se quiere lograr una buena cobertura de la herida. Se puede disponer de colgajos musculares y fasciocutáneos alimentados por pedículos confiables ubicados sobre las regiones anteriores y posteriores del muslo y sobre la región pélvica posterior, con un arco adecuado de rotación para cubrir la mayorá de los defectos pélvicos. Los colgajos más frecuentemente utilizados en nuestro estudio incluyeron: mÚsculos rectus femoris, rectus abdominis, gracilis y glÚteos máximos, junto con colgajos mÚsculocutáneos y el colgajo fasciocutáneo gluteal y del muslo. La debridación de la herida y el cubrimiento simultáneo con colgajos bien vascularizados han quedado establecidos como método Útil y confiable para la reparación de heridas complejas de la pelvis resultantes de necrosis por irradiación.
    Notes: Abstract Radiation therapy is currently utilized for primary or adjuvant therapy for pelvic tumors. Although improvements in radiation delivery techniques have largely eliminated acute complications in the radiation field, occurrences of late wound complications persist and result in complex pelvic and perineal wounds. Since these wounds reflect underlying impaired local circulations secondary to obliterative endarteritis, local wound management frequently fails either to control secondary infection or to allow spontaneous wound closure. Twenty-four patients with chronic pelvic wounds have recently undergone successful wound repair with use of muscle, musculocutaneous, and fasciocutaneous flaps. This review of these patients will demonstrate the physiologic basis for vascularized flaps for wound closure. Specific flap selection is based on the location of the pelvic radiation wound in the anterior pelvis and inguinal region, perineum and pelvic cavity, and sacrum. Well-vascularized flaps must have an independent source of circulation distant to the site of radiation damage for reliable wound coverage. Muscle and skin fascial flaps are available based on reliable pedicles located in the anterior abdominal wall, anterior and posterior thigh, and posterior pelvic region with adequate arc of rotation to cover most pelvic defects. Flaps frequently utilized in this study included: rectus femoris, rectus abdominis, gracilis, and gluteus maximus muscle and musculocutaneous flaps, and the gluteal thigh skin fascial flap. Wound debridement and simultaneous coverage with well-vascularized flaps have been established as a useful and reliable method to repair complex wounds of pelvic radiation necrosis.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-2161
    Keywords: Bone ; Metastases ; Carcinoma ; Bone tumour
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The periosteal sunburst reaction is an unusual response to metastatic bone tumours. Fifty such cases are reported in the literature, and 20 additional cases are reported in this study. The most common primary tumour showing this response is prostatic carcinoma, and the majority of cases are associated with osteoblastic metastases. Twenty percent of sunburst metastases occur in bones distal to the elbow and knee, a much higher prevalence than is found overall in bone metastases.
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  • 3
    ISSN: 1432-0533
    Keywords: Maple syrup urine disease ; Cattle ; Branched chain ketoacid decarboxylase deficiency ; Status spongiosus ; Myelin oedema
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Ultrastructural findings in the nervous systems of two Poll Hereford calves affected with maple syrup urine disease or branched chain ketoacid decarboxylase deficiency are described. The calves were affected within 2 days of birth with a severe generalised central nervous system (CNS) disorder characterised by dullness and weakness, progressing to recumbency and opisthotonus. The urine had an odour of burnt sugar. Analysis of plasma and cerebrospinal fluid demonstrated significantly elevated levels of the branched chain amino acids leucine, isoleucine and valine. Status spongiosus affecting mainly the white matter was recorded at microscopic examination of the CNS, with ultrastructural examination confirming the presence of intramyelinic vacuole formation, suggesting myelin oedema.
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  • 4
    ISSN: 1432-0533
    Keywords: Citrullinaemia ; Arginosuccinate synthetase deficiency ; Bovine ; Astroglial oedema ; Hyperammonaemia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Ultrastructural findings in the brains and livers of four calves affected with citrullinaemia due to a hereditary deficiency of the urea cycle enzyme arginosuccinate synthetase are described. The calves were affected in the 1st week of life with severe neurological disease characterised by depression, head pressing, stupor, convulsions and coma, accompanied by marked elevation of plasma citrulline and increasing plasma ammonia levels. Lesions included mild to moderate diffuse astroglial oedema in the cerebrocortical grey matter, and mild to severe hepatocellular hydropic change. The onset of the severe neurological signs was correlated with increasing levels of plasma ammonia, and the cerebral lesions were considered consistent with a bovine hyperammonaemic encephalopathy.
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  • 5
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 53 (1989), S. 0 
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: During aging of the human brain, and particularly in Alzheimer's disease, progressive neuronal loss is accompanied by the formation of highly stable intra- and extraneuronal protein fibers. Using fluorescence-activated particle sorting, a method has been developed for purifying essentially to homogeneity the extracellular amyloid fibers that form the cores of senile plaques. The purified plaque cores each contain 60–130 pg of protein. Their amino acid composition shows abundant glycine, trace proline, and ∼50% hydrophobic residues; it resembles that of enriched fractions of the paired helical filaments (PHF) that accumulate intraneuronally in Alzheimer's disease. Senile plaque amyloid fibers share with PHF insolubility in numerous protein denaturants and resistance to proteinases. However, treatment of either fiber preparation with concentrated (88%) formic acid or saturated (6.8 M) guanidine thiocyanate followed by sodium dodecyl sulfate causes disappearance of the fibers and releases proteins migrating at 5–7.000 and 11–15.000 Mr which appear to be dimerically related. Following their separation by size-exclusion HPLC, the proteins solubilized from plaque amyloid and PHF-enriched fractions have highly similar compositions and, on dialysis, readily aggregate into higher Mr polymers. Antibodies raised to the major low-Mr protein selectively label both plaque cores and vascular amyloid deposits in Alzheimer brain but do not stain neurofibrillary tangles, senile plaque neurites, or any other neuronal structure. Thus, extraneuronal amyloid plaque filaments in Alzheimer's disease are composed of hydrophobic low-Mr protein(s) which are also present in vascular amyloid deposits. Current evidence suggests that such protein(s) found in PHF-enriched fractions may derive from copurifying amyloid filament srather than from PHF.
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  • 7
    ISSN: 1432-0703
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Notes: Abstract The phthalate ester plasticizer di(2-ethylhexyl) phthalate (DEHP) affected the phagocytosis and killing ofStaphylococcus aureus by rabbit alveolar macrophages. Pre-exposure to DEHP caused a slight increase in phagocytosis and a dose-dependent inhibition of alveolar macrophage killing ofS. aureus, reaching a 14-fold decrease in the killing index at a concentration of 2 mg DEHP per 100 ml of media. The significance of this inhibition is discussed with respect to the role of the plasticizer in lung disease and macrophage research.
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  • 8
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Seven healthy men aged 21-39 years, weight 68.5-85 kg, were studied. The protocol was approved by the Ethics Committee of the Royal Postgraduate Medical School, Hammersmith Hospital and subjects gave written informed consent. Bradykinin (RIA Biochemicals) was obtained as a solid, and a sterile, ...
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  • 9
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 341 (1989), S. 226-230 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Amorphous, non-filamentous deposits of amyloid /3-protein (/3AP) without surrounding neuronal or glial alteration have recently been demonstrated in the brains of Alzheimer's disease patients and younger subjects with trisomy 2121"24. Because such 'preamyloid' deposits may represent a very early ...
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  • 10
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 333 (1988), S. 657-660 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The Galapagos Islands are thought to be the manifestation of a mantle diapir that lies immediately adjacent to the Galapagos spreading centre (GSC), an active mid-oceanic ridge (Fig. 1 ). Interaction of the hotspot with the ridge is apparent from anomalous geochemical features in GSC lava, such as ...
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