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  • 1
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    Berlin : Springer
    Call number: 02-PAT:293
    Keywords: MORPHOMETRIE / HISTOLOGIE
    Pages: XV, 300 S., ILL., TAB.
    ISBN: 0-387-19349-9
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    02-PAT:293 departmental collection or stack – please contact the library
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  • 2
    ISSN: 1432-1076
    Keywords: Coeliac disease ; Diabetes mellitus type I ; Antigliadin antibodies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Screening for coeliac disease (CD) with serum antigliadin antibodies (AGA) was performed in 1032 diabetic children and adolescents. In 8 children CD had been diagnosed before study entry. Of the remaining 1024 children, 33 had an elevated AGA titre in the first serum sample. On follow-up an elevated AGA titre was confirmed in only 17 of 31 patients. Nine of the repeatedly positive patients underwent jejunal biopsy, and CD was diagnosed in two asymptomatic patients; both were positive for IgG- and IgA-AGA. Among 10 AGA-positive patients in whom biopsies could not be performed, only 1 showed IgA-AGA and thus carried a high risk for CD. From our results we estimate a prevalence of CD in Swiss and German diabetic children between 1.1% and 1.3%. Falsepositive AGA titres occurred significantly more often in patients with diabetes duration of less than 1 year. AGA testing teached a specificity of 99% if performed at least 1 year after the onset of diabetes. Children suffering from both diabetes and CD showed a diabetes manifestation at a significantly younger age than non-coeliac patients, whereas CD tended to be diagnosed at a remarkably late age.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1076
    Keywords: Vitamin K deficiency ; Breast feeding ; Formula feeding
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Vitamin K-dependent clotting factors (FII, FVII, FX) and PT and TT were studied prospectively in 113 healthy newborns during the first 6 weeks of life. No vitamin K prophylaxis was given. Infants were divided into three groups: breast fed, formula fed or combination. The method of nutrition could not be found to influence the coagulation status.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1433-0350
    Keywords: Proliferating cells ; Growth fraction ; Ki-67 monoclonal antibody ; Pediatric brain tumor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Using the monoclonal antibody Ki-67, proliferating cells were demonstrated immunohistochemically in 16 tumors of the nervous system in children, and these findings compared with those in 44 adult tumors. The antibody, which reacts with a nuclear protein expressed during the G1, S, G2, and M phases of the cell cycle, was demonstrated in frozen (13 cases) or smear (3 cases) sections using the peroxidase-antiperoxidase method. The percentage of stained tumor cells in children was in general agreement with the histological grade, ranging from 0.2% in a schwannoma to 12.4% in a juvenile type of glioblastoma. In a medulloblastoma, the fraction of labeled nuclei was 10.2%. In malignant gliomas of children, the percentage of stained cells did not differ from that in adult tumors. However, some cases demonstrated an unusually higher number of positive cells associated with higher cellularity than did adult tumors; this is in agreement with the content of small immature tumor cells in many pediatric tumors. The use of Ki-67 staining could become an important additional criterion for predicting the biologic behavior of nervous system neoplasms in children.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Archives of virology 84 (1985), S. 283-289 
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Restriction enzyme analysis withKpnI revealed heterogeneity among 10 different strains of contagious ecthyma virus from sheep, muskox, Dall sheep and humans. Hybridization of electroblots indicated deletion of DNA segments and changes in nucleotide sequences.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-2242
    Keywords: Artificial polyploidy ; Salmonid fish ; Fertility ; Sex ratio
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary First generation tetraploids were produced by hydrostatic pressure treatment before the first cleavage and raised until the adult stage. Their survival and growth were severely depressed when compared to the diploid control: after two years, no ovulated females were found although males produced sperm at 1 and 2 years of age and were mated individually with diploid females. The progenies were consistently normal with high survival rates. They were found to be almost all triploids by karyology, which failed to detect a significant rate of aneuploidies. However, the fertilizing ability of tetraploid males was always low (0 to 97% of the control; average 40%). Several arguments presented here support the hypothesis that diploid spermatozoas, which are wider than haploid ones, would be frequently blocked during their penetration through the micropyle canal. Second generation tetraploids were produced after such matings by heat shocks, causing the retention of the second polar body. Their survival and growth were much more satisfactory than in the first generation, although still lower than in diploid and triploid controls issuing from diploid parents. Performances of second generation triploids were comparable to those of diploids, and slightly better than those of conventional triploids issuing from diploid parents. 94.5% of the second generation tetraploids were male.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-0533
    Keywords: Acquired immune deficiency syndrome (AIDS) ; Leukoencephalopathy ; Cytomegalovirus ; Papovavirus ; HTLV-III/LAV
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Two adult patients with acquired immune deficiency syndrome (AIDS) presented with psychoorganic symptoms produced by an extensive cerebral and cerebellar leukoencephalopathy. Diffuse loss of myelin and axons with reactive astrocytosis and distinctive multinucleated giant cells were prominent in the deep white matter, but less so in the subcortical white matter and in compact myelinated pathways. Bilateral involvement of the centrum semiovale produced distal Wallerian degeneration of the descending pyramidal tracts, which in one patient correlated with progressive paraparesis and bladder dysfunction. Although there were morphological indications of cytomegalovirus infection and immunohistochemical evidence of papovavirus antigens, the neuropathology did not resemble that usually associated with infection by these opportunistic agents. The possibility is entertained that the progressive diffuse leukoencephalopathy (PDL) in these patients was directly related to infection with human T-cell lymphotropic virus (HTLV-III/LAV), the etiologic agent of AIDS.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-0533
    Keywords: Chordoma ; Chondrosarcoma ; Notochord ; Tissue polypeptide antigen (TPA) ; Cytokeratin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Tissue polypeptide antigen (TPA) has been increasingly used as an immunological marker for tumors derived from the lining epithelia of body cavities, including those of the gastrointestinal tract and genitourinary and bronchopulmonary systems. Here, we present evidence that this antigen is consistently and strongly expressed by a nonepithelial lesion — the chordoma. Irrespective of their sites, all seven chordomas, including one chondroid lesion, were heavily stained. In contrast, five chondro-sarcomas were unstained or showed only focal slight positivity. TPA staining was also found to be strongly expressed by notochordal rests within the intervertebral disks of one newborn and five fetuses (15th to 32nd week of gestation), adding further evidence that these rests are the histogenetic origin of the chordoma.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1432-0533
    Keywords: Alzheimer's disease ; Neuritic plaques ; Fascia dentata ; Hippocampal formation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Neuritic plaques are prominent in the fascia dentata of the hippocampus and are often linearly oriented in stratum moleculare. Since the afferents to this region are also organized in a laminar pattern, the present study focused on the relative number and laminar distribution of plaques in this region to shed light on the genesis of the neuritic plaques. Examination of 19 brains from patients with Alzheimer's disease showed approximately the same number of plaques in the stratum moleculare of the fascia dentata and in CA1 (Sommer's sector) of the hippocampus, even though the area of the latter is much greater. Laminar analysis of plaque location showed that the plaques were centered on a band between 26% and 40% of the way between the border of stratum granulosum and the outer edge of stratum moleculare. The mean location was 35% of the way through the layer at the intersection of the inner and middle thirds. Plaques appear in approximately the same location, but in lesser numbers, in non-demented patients. The significance of this localization is discussed in terms of the normal anatomy of the fascia dentata and its possible reorganization in Alzheimer's disease. The predictability of plaque formation in this region could be useful in defining the pathogenesis of the neuritic plaque.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-0428
    Keywords: Retinopathy ; risk factors ; Type 1 diabetes mellitus in children and adolescents
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In our preceding paper, the prevalence and development of retinopathy in 231 Type 1 diabetic children and adolescents were reported to be associated with the duration of diabetes and its age at onset. This paper analyses the relationships between the development of retinopathy and the following factors: age, sex, puberty, blood pressure, insulin dosage, HLA antigens, long-term glycaemic control, and serum cholesterol and triglycerides. All these variables were longitudinally evaluated in a cohort of 322 insulin-dependent patients aged 16.2 ± 4.9 years with diabetes for 7.4 ± 5.2 years, including those 231 subjects whose eyes were examined once or repeatedly by ophthalmoscopy and fluorescein angiography. Long-term glycaemic control from the onset of diabetes to the retinal examination was assessed by both an arbitrary score comprising different parameters and by mean values of glycosylated haemoglobin, and was categorised as good, fair, and poor. With life-table analysis, the overall median individual risk for developing early retinal changes (9.1 years) was found to be significantly influenced by glycaemic control. Minimal lesions developed earlier (8.0 years) with poor control, but later with fair (10.5 years) and good glycaemic control (12.5 years) (p 〈 0.01). Mean HbA1 values below 10% delayed the onset of both incipient (10.8 years) and background retinopathy (16.6 years), while values above 10% advanced it (8.0 and 11.8 years respectively) (p 〈 0.05 and 〈 0.008). By multivariate regression and stepwise discrimination analyses, only 4 out of 14 variables were found to exert significant independent influences on the development of retinopathy: diabetes duration, long-term glycaemic control, serum triglycerides and age. The correlation coefficients with retinopathy cumulatively increased fromr=0.78 for duration of diabetes only tor=0.81 for the sum of these four factors. None of the other variables was found to increase this value any further.
    Type of Medium: Electronic Resource
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