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  • 1
    Unknown
    Freiburg im Breisgau : Aurum Verl.
    Call number: 0420:84
    Keywords: Moerman, Cornelis ; Cancer / Diet therapy
    Notes: Translation of: De Moerman therapie
    Pages: 84 p.
    Edition: 3. Aufl.
    ISBN: 3591081132
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    0420:84 departmental collection or stack – please contact the library
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  • 2
    ISSN: 1432-0983
    Keywords: Yeast ; Mutagenesis ; Base analogues
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Cells of the yeast, Saccharomyces cerevisiae, which are auxotrophic for thymidylate (tmp1) can also incorporate analogues of thymidylate. When the base analogue, 5-bromodeoxyuridylate, is incorporated into tmp1 yeast cells it is lethal and mutagenic. Both lethality and mutation induction can be drastically altered by perturbation of the pyrimidine nucleotide pools. Analysis of mutation induction, bromodeoxyuridylate incorporation into DNA, and cell viability under various conditions revealed: (1) lethality and mutagenesis can be uncoupled, (2) thymidylate enhances mutagenesis and deoxycytidylate suppresses it, (3) mutation induction is not correlated with the magnitude of bromodeoxyuridylate incorporation into DNA. Therefore, in yeast, the pyrimidine nucleotide pools have a powerful effect on bromodeoxyuridylate mutagenesis. Both bromodeoxyuridylate and iododeoxyuridylate are extensively incorporated into the DNA of tmp1 yeast cells; however, iododeoxyuridylate is non-mutagenic. Replication proceeds at the same rate in the presence of the natural substrate or either analogue. When cells are supplied with thymidylate and bromodeoxyuridylate together, there is no discrimination against bromodeoxyuridylate as a DNA precursor. However, in the presence of thymidylate and iododeoxyuridylate, there is a 3 to 1 discrimination against iododeoxyuridylate as compared to thymidylate.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1076
    Keywords: Neonate ; Tachypnoea ; Fractured ribs
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Two macroscopic term neonates are described who presented with uncomplicated tachypnoea immediately following vaginal delivery. The tachypnoea was not associated with lung injury, metabolic, endocrine or cardio-respiratory disease but with multiple unilateral posterior rib fractures. The neonatologist should be aware that neonatal tachypnoea immediately after vaginal term delivery, especially in macrosomic infants, may be caused by the pain of fractured ribs. The diagnosis can be made only by careful inspection of the ribs on chest X-ray.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Detailed restriction enzyme analysis of the DNA from a Chinese female showed that one of her chromosomes had a 〉17.5 kb deletion of DNA, including the ψα, α2, and α1 globin genes, which is present in many Southeast Asians with an α-thalassemia-1 chromosome. Her “normal” chromosome had the expected cluster of α-like globin genes (5′-ζ-ψζ-ψα-α2-α1-3′), but the segment of DNA between the two α globin genes was elongated by some 0.5–0.7 kb. Analyses of various restriction sites suggested that this normal variant of the human α globin gene complex is due to a crossover between a normal chromosome with (αα) and a chromosome with an α-thalassemia-2 (−α3.7) and an -α2α1-hybrid gene.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1434-6079
    Keywords: 36.40 ; 64.70
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The evolution of thermodynamic, dynamic and quantum size effects in clusters is expected to contribute towards the merging between microscopic and macroscopic points of view in molecular, surface and bulk phenomena.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1617-4623
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary We report that centrifugation at relatively high g-forces reduces the ability of competent cells of Bacillus subtilis to bind and take up DNA, and to be transformed. The centrifugation supernatant from competent cells restores this reduction of competence; the supernatant from non-competent cells is inactive. Phosphocellulose chromatography of centrifugation supernatants from radioactive competent cultures gave rise to six sharp peaks, together, these were shown by subsequent SDS polyacrylamide gel electrophoresis to contain over 60 different polypeptide bands. Peak II, which showed competence restoring activity, produced three polypeptides. When these bands were further examined, one of these exhibited DNA binding activity and the other two each contained a different endonuclease. Competence restoring activity was not recovered from the SDS polyacrylamide gel of peak II. The three peaks from non-competent cultures produced altogether five faint bands in gel electrophoresis. None of these bands were similar to those found in peak II.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Superconducting thin films of Y-Ba-Cu oxide have been prepared on yttria-stabilized zirconia substrates using metal trifluoroacetate spin-on precursors. The films exhibit an extremely sharp resistive transition with zero resistance at temperatures as high as 94 K. The superconducting phase is formed by a three-step process: (a) decomposition of the spun-on trifluoroacetate film to the fluorides, (b) conversion of the fluorides to oxides by reacting with water vapor, and (c) annealing followed by slow cooling in oxygen. The properties of the films depend on the amount of conversion of the fluorides by reaction with water. Films which show the presence of some unreacted barium fluoride have strong c-axis normal preferred orientation, with a sharp resistive transition. When all the barium fluoride is converted, the film is more randomly oriented and exhibits a broader transition to zero resistance.
    Type of Medium: Electronic Resource
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  • 8
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: The energetics of the negatively charged water dimer (H2O)−2, is studied using quantum-simulation techniques and ab initio electronic structure calculations. Using the RWK2-M potentials for water and a pseudopotential for the interaction of an electron with a water molecule in the ground state, consisting of Coulomb, adiabatic polarization, exclusion, and exchange contributions, it was found via the quantum path-integral molecular dynamics and the coupled quantum-classical time-dependent self-consistent field methods that while the minimum energy of (H2O)−2 corresponds to a nuclear configuration similar to that found for the neutral (H2O)2 cluster, other nuclear configurations are also exhibited at finite temperature, characterized by a higher total molecular cluster dipole moment and a larger magnitude of the excess electron binding energy. Quantitative agreement is found between the results obtained by the quantum simulations, employing the excess electron–molecule pseudopotential, and those derived, for selected nuclear configurations, via ab initio calculations, employing the Gaussian 86 code with the basis set for the water molecules supplemented by a large diffuse set located at the midpoint of the two oxygens and in addition by a diffuse set for the excess electron.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 90 (1989), S. 4413-4422 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Relaxation dynamics following an electronic transition of an excess solvated electron in clusters and in bulk water is studied using an adiabatic simulation method. In this method the solvent evolves classically and the electron is constrained to a specified state. The coupling between the solvent and the excess electron is evaluated via the quantum expectation value of the electron–water molecule interaction potential. The relaxation following excitation (or deexcitation) is characterized by two time scales: (i) a very fast (∼20–30 fs) one associated with molecular rotations in the first solvation shell about the electron, and (ii) a slower stage (∼200 fs), which is of the order of the longitudinal dielectric relaxation time. The fast relaxation stage exhibits an isotope effect. The spectroscopical consequences of the relaxation dynamics are discussed.
    Type of Medium: Electronic Resource
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