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  • 1
    Electronic Resource
    Electronic Resource
    New York, NY : Wiley-Blackwell
    BioEssays 8 (1988), S. 161-162 
    ISSN: 0265-9247
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-0428
    Keywords: Genetics ; insulin gene ; DQβ gene ; fibrocalculous pancreatic diabetes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Fibrocalculous pancreatic diabetes (previously known as tropical pancreatic diabetes) is a rare cause of diabetes confined to countries within the tropical belt. The aetiology of fibrocalculous pancreatic diabetes is thought to be environmental although the agent(s) is unknown. We have investigated a possible genetic basis of this disease by looking for restriction fragment length polymorphisms of genes implicated in the aetiology of diabetes mellitus. Seventy-six Dravidian patients with fibrocalculous pancreatic diabetes were studied, and the restriction fragment length polymorphisms obtained compared to racially matched control subjects (n=94), patients with Type 2 (non-insulin-dependent) diabetes (n=87) and Type 1 (insulin-dependent) diabetes (n=58). No association of fibrocalculous pancreatic diabetes was found with restriction fragment length polymorphisms of the insulin receptor gene. Although no association of fibrocalculous pancreatic diabetes was found with polymorphism of the HLA DRα/DQα/DXα genes, an association was found with the Taq 1 restriction fragment length polymorphisms of the DQβ gene (DQβ T2/T6 present in 39% of patients with fibrocalculous pancreatic diabetes compared to 19% in control subjects; p=0.01; corrected p value=0.04) which is similar to that found in Type 1 but not Type 2 diabetes. An association of fibrocalculous pancreatic diabetes was also found with the hypervariable region in the 5-prime flanking region of the insulin gene; 40% of patients possessed the class 3 allele compared to 9.5% of control subjects p=0.0001; corrected p value=0.0008). In Type 2 diabetes, similar results were obtained with 33% subjects possessing the class 3 allele (p value compared to control subjects=0.0005; corrected p value=0.004). This study suggests that fibrocalculous pancreatic diabetes has a genetic component in its aetiology. Furthermore, its origin might be related to an individual with part of the genetic predisposition to diabetes (Type 1 or Type 2) who additionally has evidence of chronic calcific pancreatitis.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Annals of operations research 9 (1987), S. 589-611 
    ISSN: 1572-9338
    Keywords: Reliability ; fault tolerance ; bounds on reliability ; bounds on mean time until failure ; avionics reliability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics , Economics
    Notes: Abstract The U.S. Air Force is developing an Integrated Communications, Navigation, and Identification Avionics (aviation electronics) system with the acronym ICNIA for use in tactical aircraft. Designers of ICNIA as well as the Air Force need to be informed of the reliability of proposed designs. Hence, the Air Force contracted The Analytic Sciences Corporation (TASC) to develop a model of the ICNIA system and to develop algorithms for determining various system performance measures such as the system reliability. TASC developed the ICNIA model and developed a software package called MIREM to analyze ICNIA systems. Unfortunately, due to the complexity of ICNIA, the developers of MIREM were forced to incorporate several approximations in MIREM. In the report by Foley [2], we showed that these approximations can perform poorly in some artificially constructed examples. Their accuracy on realistic examples is unknown. We have developed and implemented two algorithms for analyzing ICNIA. The algorithms do not use any approximations and are computationally feasible on realistic sized examples. It is recommended that MIREM be modified to use the algorithms described in this paper.
    Type of Medium: Electronic Resource
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