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  • 1985-1989  (4)
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  • 1
    ISSN: 1572-8404
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Philosophy
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Biology and philosophy 3 (1988), S. 497-499 
    ISSN: 1572-8404
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Philosophy
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Peripheral blood and bone marrow mononuclear cells from 25 children with acute non-lymphoid leukaemia were analysed for natural killer cell activity and for cells with the Leu-7 and Leu-11b(CD 16) markers. Significantly reduced spontaneous cytotoxicity was detected in peripheral blood from children with untreated and active acute non-lymphoid leukaemia compared with that of the controls (P=0.01 and P〈0.05). Patients to remission, however, had normal natural cytotoxicity and normal number of Leu-7 and Leu-11b(CD 16)-positive cells. The natural killer cell activity in hone marrow from patients with untreated acute non-lymphoid leukaemia was also significantly reduced (P=0.025). On die other hand, patients in remission had both an increased percentage of Leu-7 and Leu-11b (CD 16)-positive cells (P〈0.05) and an increased natural killer cell activity (P〈0.0005) in their bone marrow cells in comparison with the control group. This augmented natural killer cell activity is most probably a result of anti-leukaemic treatment. Stimulation with recombinant alpha interferon and recombinant interleukin 2 caused an increase in natural killer cell activity that was both significant and normal in both peripheral blood and bone marrow from children with acute non-lymphoid leukaemia.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-1971
    Keywords: Cerebral perfusion ; Cardiac surgery ; Pediatric surgery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Six children undergoing major cardiac surgery had extensive cerebral monitoring during cardiopulmonary bypass (CPB). The monitoring included continuous recording of arterial blood pressure (BP), central venous pressure (CVP), cerebral electrical activity by a cerebral function monitor (CFM), and middle cerebral artery (MCA) flow velocity by the transcranial pulsed Doppler (TCD) technique. Introduction of the precooled blood containing priming solution resulted in rapid fall in BP as well as MCA velocities in these children at the start of CPB. During steady-state CPB at 20°C, MCA flow velocities were reduced in five of six children, range 45%–105% of pre-bypass value. These flow velocity values were recorded at cerebral perfusion pressures (CPP=BP−CVP) in the range of 14–26 mmHg. This reduced cerebral perfusion during steady-state CPB appears to be more than sufficient to meet the cerebral metabolic demands at the particular temperature. The reduced cerebral perfusion is in contrast to the enhanced perfusion found in adults during moderately hypothermic (28°–30°C) low-flow, low-pressure CPB previously reported. It was presumably due to the reduced temperature, reduced perfusion pressure, and less hemodilution. During periods of constant temperature, hematocrit, and partial pressure of carbon dioxide (PaCO 2), MCA flow velocities varied passively with changes in CPP, demonstrating that cerebral autoregulation was not operative. Transcranial Doppler appears to be a suitable tool for investigating CPB techniques optimal with respect to cerebral circulation.
    Type of Medium: Electronic Resource
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