Benzyl-dimethylammonium- and phenyl-dimethylammonium-acetic acid betaine
1,3-Dimethylammonium-butyl acetic acid betaine
1,4-Dimethylpiperazinium acetic acid betaine
Springer Online Journal Archives 1860-2000
Chemistry and Pharmacology
Abstract The influence of substituents at the ammonium nitrogen of acetic acid betaines on the reaction with trifluoracetic anhydride (TFA) has been investigated. Thus benzyl-dimethyl- and phenyl-dimethyl-betaines (1a, 1b) as well as the bifunctional betaines derived from 1,3-bis-(dimethylamino)-butane (5) or 1,4-dimethylpiperazine (7) may serve as examples. From these betaines, the symmetrical compound7 gives in 50% yield 1,4-dimethyl-piperazinium-ditrifluoracetyl-dimethylide (8), while the tendency of formation of the di-acyl-N-ylides2a, 2b, and6 is rather low.
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