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  • 1
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Twenty-three independent man-hamster (CH/HGPRT-) hybrids were analysed for human acid lipases and for some other human enzyme markers (PP, GOT 1, PGP) and chromosomes. Eighteen independent man-mouse (LA/HGPRT-TK−) hybrids were analysed for human acid lipases, human enzyme marker PGP and human chromosomes. Three fibroblasts from unrelated patients with WD (Wolman's disease), one fibroblast from a heterozygote for WD, and 15 normal fibroblasts were analysed for acid lipases. The following results were obtained: 1) A positive correlation was observed between acid lipase A and Chr. 10, and between acid lipase B and Chr. 16. In fact, among 23 independent man-hamster hybrids, 6 were Chr. 10+PP+GOT 1+LIP A+ and 17 were Chr. 10-PP-GOT 1-LIP A-, and among 41 independent man-rodent hybrids 23 were Chr. 16+ PGP+LIP B+ and 18 were Chr. 16-PGP-LIP B-. Except for Chr. 10, the other autosomes were observed in hybrids LIP A−, and except for Chr. 16, the other autosomes were observed in hybrids LIP B-. These results indicate that the gene for lipase A is on Chr. 10 and the gene for lipase B is on Chr. 16. 2) The acid lipase A is deficient in WD fibroblasts. Therefore the mutation responsible for WD is on Chr. 10. The B, C and at least three additional lipases were observed in WD fibroblasts and in WD heterozygote fibroblasts at pH 4.0 and with 4-methylumbelliferyl oleate as substrate. The relationship between these different acid lipases are obscure. In the normal fibroblasts from healthy control subjects a considerable variation in acid lipase A activity was observed. In some normal fibroblasts from healthy control subjects, in which the lipase A is reduced, we observed the same acid lipase zymogram pattern as in WD heterozygote fibroblasts.
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  • 2
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The tissue distribution of different glutathione S-transferases (GST) is analysed by electrophoresis. 1) The existence of GST“e” (erythrocyte), GST3, GST1, and GST2 is confirmed. GST“e” the fastest and most thermolabile of different GST analysed is observed only in erythrocyte cells. GST3 which migrates more slowly than GST“e” is present in all tissues and cells analysed, excepted for erythrocyte cells in which only GST“e” is observed. GST1 presents a polymorphism with four phenotypes 1, 1/2, 2, and 0 controlled by three alleles 1, 2, and 0 (null). With the sample of 56 livers analysed the different frequencies obtained are 9%, 5%, 43%, 43% for the phenotypes 1, 1/2, 2, and 0 respectively and 0.074 (p), 0.279 (q), 0.647 (r) for the alleles 1, 2, and 0 (null). GST2 presents variant patterns due probably, in the majority of cases, to post-synthetic modifications rather than allelic variation. 2) Two new GST are described, GST4 and GST5. GST4 abundant in muscle tissue is a dimeric protein. GST4 forms with GST1 a heterodimeric band. GST5 is observed in brain homogenates. 3) For the chromosome localization the results obtained by man (leucocytes)-mouse somatic cell hybrid analysis indicate that the gene for leucocytes GST is on chromosome 11. This gene is the structural GST3 gene.
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  • 3
    ISSN: 1432-5195
    Keywords: Hallux valgus ; Gait analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Les auteurs décrivent une méthode d'évaluation globale du pied, tant avant qu'après correction chirurgicale, chez des adolescents porteurs d'hallux valgus. Elle nécessite une série d'études des caractéristiques cliniques, photographiques et radiologiques, ainsi qu'une évaluation dynamique de la marche à l'aide d'un plateau de force. Cette méthode a été utilisée pour estimer avec exactitude les modifications survenues sur 36 pieds après que l'hallux valgus ait été traité par une variante de l'ostéotomie oblique du premier métatarsien décrite par Wilson, qui consiste en une résection d'un coin osseux suivie de fixation par une vis. Durant les six premiers mois post-opératoires, on note un déplacement de l'appui de l'avant-pied vers le dehors et une diminution de la charge au niveau des orteils, mais il y a une tendance à revenir à la répartition pré-opératoire de l'appui au cours des quatre années suivantes. La persistance du déplacement externe de l'appui semble résulter de la surélevation de la tête du premier métatarsien, conséquence du raccourcissement de cet os créé par l'ostéotomie. Ceci peut être évité en abaissant délibérément la première tête métatarsienne lors de l'opération et en fixant les fragments par une vis dans la position désirée.
    Notes: Summary A comprehensive method of evaluating the feet of patients with adolescent hallux valgus both before and after surgical correction is described. Serial clinical, photographic and radiological studies were made and a dynamic assessment of gait was carried out using a load-sensitive walkway. Observations were made on 36 feet in which hallux valgus was treated by a modification of the Wilson oblique metatarsal osteotomy, with removal of a wedge of bone and screw fixation. In the first six months after operation, there was a lateral shift of the weight-bearing pattern in the forefoot and less weight was taken on the toes, but there was a tendency to return to the pre-operative distribution of weight during the next four years. Persistence of the lateral shift of weight-bearing appeared to result from elevation of the first metatarsal head secondary to shortening of the first metatarsal during the osteotomy. This can be avoided by deliberate depression of the first metatarsal head at the time of operation and fixation of the fragments in the required position with a screw.
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  • 4
    ISSN: 1432-0533
    Keywords: Experimental allergic neuritis ; Cyclosporin-A
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Experimental allergic neuritis (EAN) was induced in guinea pigs and rats and treated with Cyclosporin-A (Cy-A). When Cy-A was given prophylactically for 1 month from the time of induction of the disease, it prevented the development of EAN during the course of its administration. When Cy-A was given therapeutically after the onset of neurological signs, it effectively prevented further deterioration. This effect was more marked after 3 weeks' treatment than after only 1 week's treatment. In both regimens, when dosing with Cy-A ceased there was a latent period before clinical signs of EAN developed. This latent period is similar to that seen in the development of EAN in normal control animals and is probably due to the continued presence of antigen at the injection sites. After primary treatment of EAN with Cy-A, animals that relapsed did not respond to further treatment with Cy-A. Histological examination revealed that the nature of the EAN lesions in both groups of animals given Cy-A were not as severe as those seen in control animals. Despite these observations, there was no statistically significant difference between the maximum clinical grades reached by animals in any one group. These experiments suggest that T-cells are important in the development of EAN and that Cy-A interferes with this process by suppressing T-helper cells. They also show that it is possible to influence favourably the course of immune mediated neurological disease.
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  • 5
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral rehabilitation 10 (1983), S. 0 
    ISSN: 1365-2842
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The intra-radicular hydrostatic pressures generated during the cementation of parallel-sided dental posts have been measured. Pressures are generated only when cement is inserted into the prepared post hole. Using zinc phosphate cement, with posts placed 2 min from the commencement of mixing, pressure has been shown to depend on post diameter, the closeness of fit, and the powder-liquid ratio. The maximum pressure recorded was 1.7 × 104 kN/m2 using a 1.3 mm diameter post, a mean cement film thickness of 37 μm, and an ideal powder-liquid ratio of 3.0. Pressures similar to that generated using zinc phosphate cement were recorded when black copper phosphate was used as the lute, but zinc polycarboxylate generated less pressure, and an ortho-ethoxy benzoic acid cement markedly less pressure.Before it is possible to confirm the ideal luting cement for posts, further studies of the effectiveness of cement release channels, and post retention. are necessary.
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  • 6
    ISSN: 1365-2842
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Intra-radicular pressures during the cementation of screw-retained posts have been found to reach 1.5 × 104 KN/m2 when cement is inserted into the prepared post hole or no pressure, indicating that an incomplete cement lute had developed, when the post was coated with cement. The effectiveness of cement channels was investigated and for the traditional single channel, using the cement ‘insertion’ method, there was an intra-radicular pressure of 8.5 × 104 KN/m2, compared with 1.1 × 104 KN/m2 for the corresponding round post. Multiple cement release channels* gave an enhanced pressure reduction to 2.0 × 103 KN/m2.
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  • 7
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of agricultural and food chemistry 31 (1983), S. 1377-1378 
    ISSN: 1520-5118
    Source: ACS Legacy Archives
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Inorganic chemistry 19 (1980), S. 1386-1388 
    ISSN: 1520-510X
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Inorganic chemistry 22 (1983), S. 3233-3236 
    ISSN: 1520-510X
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1520-510X
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
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