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  • 1980-1984  (4)
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  • 1
    ISSN: 1432-0851
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Blood lymphocytes from 100 patients with transitional cell carcinoma of the urinary bladder (TCC-bladder) were studied for their cytotoxicity in vitro against a panel of allogeneic tissue culture cell lines. Of the TCC-bladder patients, 45 were untreated for their disease, while 55 had been treated with local radiotherapy up to 12 years before testing. Control lymphocytes were obtained from (1) 45 untreated, age- and sex-matched patients with other neoplastic diseases, mainly urogenital cancers; (2) 19 patients with acute cystitis; and (3) 45 healthy donors. Lymphocytes from individual donors within all five groups were frequently cytotoxic to any one of the target cells. However, the lymphocytes from each of the two TCC-bladder groups were markedly more cytotoxic to two different bladder tumor targets than to control targets derived from normal bladder epithelium, from colon carcinoma, or from malignant melanoma. Similar comparisons made within each of the three control donor groups did not show this. The results indicate that the two bladder tumor targets were not more susceptible to lymphocyte-mediated lysis than the control targets. The mean cytotoxicity displayed by the lymphocytes from both TCC-bladder groups to the bladder tumor targets was significantly higher than that of the cancer control group and that of the healthy donors. No such elevation was seen when the cancer control group or the cystitis patients were compared with healthy donors. Although untreated TCC-patients with a larger tumor burden (stages T3–T4) appeared to be slightly less cytotoxic to all target cells than those with a smaller tumor burden (T1–T2), these differences were not statistically significant. On the other hand, among the treated TCC-patients, in the main those tested more than 1 year and up to 5 years after therapy exhibited a significantly elevated mean cytotoxicity to the bladder tumor targets. Within all five donor groups, the overall cytotoxicity to the bladder tumor targets and the normal bladder targets showed a statistically highly significant correlation. However, while there was no correlation for the untreated TCC-bladder patients and the clinical controls between cytotoxicity to the bladder tumor targets on one hand and non-bladder targets on the other, the cytotoxicity to the bladder tumor targets of the treated TCC-bladder patients was also correlated with that to the colon carcinoma and the melanoma targets. The results indicate that cytotoxicity in both TCC patients and controls reflects recognition by the lymphocytes of a variety of antigens, shared to different degrees by different groups of target cells. Furthermore, in TCC-bladder patients there is a superimposed cytotoxicity, which is related to their disease and which probably reflects reactions against one or several tumor-associated antigens.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 0942-0940
    Keywords: Glioblastoma multiforme ; human ; interferon
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This report presents the results of a phase I trial of the value of human leucocyte inferon-alpha in the treatment of glioblastoma. Twelve patients entered the trial. In one case we believe that the patient benefitted from the interferon treatment. CT scans of patients on interferon did not reveal the true extent of the tumorous tissue.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Lymphocytes from C3HXCBA hybrid mice proliferate intensely in the spleens of irradiated CBA mice. Presentment of the CBA hosts with C3HXCBA spleen cells, known to specifically reduce the T-cell reactivity of the hosts against the strongly stimulatory Mls-antigen determined by the C3H-genome, abolished the capacity of the host to promote proliferation of C3HXCBA lymphocytes. In contrast, proliferation of C3HXCBA bone marrow cells, as measured by splenic 59Fe incorporation, was unaffected by such pretreatment. By examining the capacity of spleen cell populations of (C3HXCBA)XCBA back-cross mice to inhibit lymphocyte proliferation, as described above, and to express the C3H-delermincd Mls-antigen, it was concluded that these two trails are associated.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bestatin, ein neuer, chemisch definierter Immunmodulator, wurde auf seine Fähigkeit zur Verstärkung der Phagozytoseaktivität neutrophiler Granulozyten von Patienten mit Furunkulose geprüft. Bei 19 Patienten mit rezidivierender Furunkulose war die Fähigkeit der Granulozyten zur Aufnahme Fluoresceinmarkierter Hefepartikel signifikant verändert (p〈0,01). Zehn Patienten wurden mit 40 mg Bestatin oral behandelt; daraufhin nahm die Phagozytosefunktion ihrer Granulozyten signifikant zu (p〈0,01).
    Notes: Summary Bestatin, a new immunomodulator which is chemically well-defined, was examined for its capacity to enhance the phagocytic activity of neutrophilic granulocytes from patients with furunculosis. The ability of the granulocytes to ingest fluorescein-labelled yeast particles was significantly decreased in 19 patients with recurrent furunculosis (p〈0.01). Oral administration of 40 mg bestatin to ten patients increased the phagocytic function of their granulocytes significantly (p〈0.01).
    Type of Medium: Electronic Resource
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