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  • 1
    ISSN: 1432-0428
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-0428
    Keywords: Haemoglobin A1c ; synthesis ; glucose ; hyperglycaemia ; artificial pancreas ; density separated erythrocytes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The synthesis of glycosylated haemoglobins in vivo was measured during 24 h of controlled hyperglycaemia in seven insulin dependent diabetics. The mean blood glucose concentration was 22 mmol/l, while electrolytes and other metabolites were kept normal by infusion of 4–23 IU of insulin during hyperglycaemia. The study confirmed the velocity and magnitude of unstable HbA1c formation previously found in vitro. The stable HbA1c formed in 24 h was on average 0.006% of total haemoglobin/ mmol glucose. This compares well with the rate of HbA1c synthesis reported in normal subjects using 59Fe-kinetic measurements, and is in accordance with the concept of slow changes in stable HbA1c with time and glucose concentration. To investigate the possibility that the rate of HbA1c synthesis varies with erythrocyte age, glycosylated haemoglobins were measured in erythrocyte fractions after density separation on Percoll-Albumin gradients. We found both in normal subjects and in insulin treated diabetics that the 5% least dense cells contained 70%–80% of whole blood HbA1c. Assuming the least dense cells to be the youngest erythrocytes, this observation is inconsistent with a slow linear increase in HbA1c. Similar results were obtained in six newly diagnosed insulin dependent diabetic patients both before and after the first 30 days of insulin treatment, even though a marked decrease in young cell HbA1c would be expected with the improved glucose control observed. We therefore conclude that density separation of erythrocytes is an inadequate technique to study age related HbA1c synthesis.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-0428
    Keywords: Type 1 diabetes ; diabetic nephropathy ; hypertension ; proteinuria ; serum creatinine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The relationship between arterial blood pressure and diabetic nephropathy was examined in 61 Type 1 (insulin-dependent) diabetic patients (22 females and 39 males). All patients fulfilled the following criteria: persistent proteinuria (〉0.5g/day), onset of diabetes before 31 years of age, age 〈42 years, serum creatinine 〈130 μmol/l, and no antihypertensive treatment. Thirty Type 1 diabetic patients without persistent proteinuria but matched for sex, age, ideal body weight and duration of diabetes, and 30 healthy subjects matched for sex, age and ideal body weight were also studied as controls. The diabetic patients with persistent proteinuria had elevated blood pressures (146/96±17/10 mmHg, mean±SD) compared with 123/75±11/8 mmHg in diabetic patients without persistent proteinuria, and normal subjects (120/77±6/6 mmHg; p〈0.001 for each). Diastolic blood pressure ⩾95 mmHg was found in 51% of the group with persistent proteinuria. Elevated arterial blood pressure is frequently present in young Type 1 diabetic patients with diabetic nephropathy and normal serum creatinine.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-0428
    Keywords: Type 1 diabetes ; metabolic control ; dark adaptation ; electroretinography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The oscillatory potential of the electroretinogram and the initial 2-min phase of dark-adaptation were studied in seven newly diagnosed Type 1 (insulin-dependent) diabetic patients before and during initial insulin treatment. Strict metabolic control was achieved in all seven patients using multiple subcutaneous injections of insulin. Seven to 11 days of strict metabolic control improved the added amplitude value of the oscillatory potential from 236±8 to 268±8 μV (mean±SEM; p 〈 0.01) and the dark-adaptation from 90 ±5 to 67±5 s (p 〈 0.01). Our study has demonstrated reversible neurophysiological abnormalities in the diabetic retina which are related to metabolic control.
    Type of Medium: Electronic Resource
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