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  • 1
    ISSN: 1432-1041
    Keywords: ouabain ; nitroglycerin ; cardiac glycosides ; impedance cardiography ; systolic time intervals ; echocardiography ; cardiac load changes ; pharmacodynamic effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In this intraindividual, placebo-controlled, double blind study the dynamic effects of single doses of ouabain 0.5 mg i.v. and 12 mg sublingual were compared with those of the vasodilator sublingual nitroglycerin 0.8 mg. In 12 (sublingual) and 6 (i.v.) healthy volunteers, respectively, cardiac performance was assessed for 60 min after administration, using systolic time intervals (QS2c, PEPc, PEP/LVET), electrical impedance cardiography ((dZ/dt)/RZ index) and echocardiography (EDD, ESD, FS). After i.v. ouabain the typical positive inotropic glycoside effects appeared (shortening of QS2c, PEPc, and PEP/LVET, increase of (dZ/dt)/RZ and FS, decrease of EDD and ESD). With nitroglycerin preload reduction diminished cardiac performance, as shown by a rise in PEPc and PEP/LVET and depression of (dZ/dt)/RZ. In addition, EDD (not significant) and ESD were somewhat reduced, FS was enhanced, and QS2c tended to shorten. Following sublingual ouabain, QS2c was unchanged, there was an increase in PEPc and PEP/LVET, a decrease in (dZ/dt)/RZ and FS, EDD was unchanged, and ESD rose. By this route the absolute magnitude of the effects was about 1/3 that of the i.v. drug action. The spectrum of effects of sublingual ouabain indicates a reduction in cardiac performance without any detectable inotropic action. The effects seem to be induced by load changes, with an indication of an increase in afterload although an additional preload reduction cannot be excluded. This dose of the drug given by the sublingual route appears, therefore, to alter cardiac function via an effect on the peripheral circulation, although the final mechanism has not yet been elucidated. It is not known whether these biological effects in healthy subjects may have any clinical significance in patients with cardiac disorders.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1971
    Keywords: Aortic valve stenosis ; Endocardial fibroelastosis ; Neonates ; Left ventricular dysfunction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 30 patients with severe aortic valve stenosis presented in severe congestive heart failure within the first 2 months of life. In 25 of them, left ventricular volume and contractility were assessed; five of them had a left ventricle of normal size, in 11 left ventricular size was diminished, and in nine patients it was enlarged. Eleven of the infants had extensive endocardial fibroelastosis (EFE) evidenced angiographically by myocardial sinusoids in ten of them and established at autopsy in six. The presence of EFE correlated with the size of the left ventricle; eight of 11 with a small left ventricle, two of five with a normal-sized left ventricle, and one of nine with an enlarged left ventricle displayed EFE. The severe depression of left ventricular function associated with EFE was documented by left ventricular volume determinations on exclusion of the myocardial sinusoids. Of 30 patients, 12 (including eight of 26 who underwent surgery) did not survive. Mortality, severity, and early onset of symptoms were associated mainly with small size of the left ventricle and with the severe left ventricular dysfunction associated with EFE.
    Type of Medium: Electronic Resource
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