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  • 1
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1106
    Keywords: Climbing fibers ; Mossy rosettes ; Bands
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The pathways and terminal projections of the inferior olivary complex and the lateral reticular nucleus (LRN) to the cerebellar nuclei and cortex in the rat were studied using unilateral and bilateral injections of 35S-methionine followed by light microscope autoradiography. The cerebellar projections from unilateral olivary injections show heavy contralateral, crossed and light, ipsilateral, uncrossed projections in sagittal bands in the deep nuclei and in the molecular layer. The crossed projections occupy all cortical lobules. Bilateral olivary injections that encompassed all subdivisions of the nuclear complex on both sides demonstrated that the same pattern of sagittal zonation is preserved although in this case distributed bilaterally. Thus, the representations of ipsilateral and contralateral projections of both sides overlap precisely and banding is preserved. These data suggest that the olivocerebellar climbing fibers occupy the banded areas and that the empty strips of molecular layer between them must have climbing fibers of extra-olivary origin. It was also found that climbing fiber rosettes are present in the granular layer borne by collaterals of axons en route to the molecular layer; their distribution is not restricted to the molecular layer bands. Unilateral injections in the LRN produced heavy, uncrossed, ipsilateral and light, crossed, contralateral projections with the crossing occurring in the cerebellum. Projections to the deep nuclei occur and the terminal arborizations in the cortex are dense fields of mossy fiber rosettes forming narrow sagittal bands restricted to the granular layer. These mossy fiber rosettes contrast sharply in their number and distribution to the climbing fiber rosettes. The data from these studies strengthen the evidence gathered from morphological and physiological studies that the entire cerebellum may be organized on a plan involving narrow sagittal strips with structural, functional and chemical significance.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A starch gel electrophoretic procedure is described that resolves peptidase S (PEPS) as well as the peptidases A, B, and C in man-rodent, rodent-rodent, and primate-rodent interspecific somatic cell hybrids. The interspecific PEPS cell hybrid phenotype can be resolved into a pattern which suggests that PEPS is composed of five or six identical subunits. Results are presented supporting assignment of the PEPS locus to chromosome 4 in man using man-mouse and man-Chinese hamster somatic cell hybrids. Human genes coding for peptidases A, B, C, and D were assigned to chromosome 18, 12, 1, and 19, respectively, confirming previous assignments. These somatic cell genetic data demonstrate the independent genetic control of the several human peptidases.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-1017
    Keywords: Calcium ; Limulus ; Photoreceptors ; Adaptation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Notes: Abstract Calcium ion fulfills several criteria for identifying an intracellular messenger for light-adaptation in Limulus photoreceptors. Direct injection of Ca++ mimicks two aspects of light-adaptation; sequestration of intracellular calcium tends to prevent light-adaptation; and light induces an increase in intracellular Ca++ as demonstrated by two independent techniques.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-1041
    Keywords: Tetracyclines ; half life ; volume of distribution ; renal clearance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The disposition of minocycline, tetracycline, doxycycline and oxytetracycline was investigated in four male volunteers after multiple dosing. Values for half life, renal clearance and volume of distribution were calculated and corrected for plasma protein binding. Tetracycline and oxytetracycline have a much larger volume of distribution than minocycline and doxycycline but similar half lives. They give higher tissue levels for equivalent plasma levels. Since their cost per unit dose is much lower they should be the tetracyclines of first choice.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Skeletal radiology 3 (1979), S. 250-253 
    ISSN: 1432-2161
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-0428
    Keywords: GIP ; gastrin ; insulin ; incretin ; chronic pancreatitis ; test meal ; malassimilation of fat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Twenty-nine patients with chronic pancreatitis had a significantly greater IR-GIP response to a test meal than 15 controls. This increased response was not related to the degree of steatorrhoea or glucose intolerance. It was most marked in a group of patients with moderately impaired IRI release and medium steatorrhoea. From this is concluded that the IR-GIP response to a test meal is determined by at least two factors: 1. feedback control via insulin secretion, 2. assimilation of fat. In chronic pancreatitis endocrine insufficiency may induce an exaggerated GIP response and severe exocrine insufficiency may prevent fat induced GIP release. Gastrin is not involved in the different GIP response in patients with chronic pancreatitis.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-0428
    Keywords: GIP ; gastrin ; insulin ; incretin ; coeliac disease ; duodeno-pancreatectomy ; chronic pancreatitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The response of serum immunoreactive gastric inhibitory polypeptide (IR-GIP), gastrin (IRG) and insulin (IRI) to a mixed standard meal was measured in 15 controls, 6 patients with coeliac disease, 26 patients with chronic pancreatitis and 6 patients with chronic pancreatitis and partial duodenopancreatectomy (Whipple's procedure). Serum levels of IR-GIP, IRG and IRI were significantly reduced in patients with coeliac disease. The serum glucose increase was significantly smaller only during the first hour after the meal. Since small intestinal GIP- and G-cells are situated mainly in the glands of duodenal and jejunal mucosa their absolute number is not significantly reduced in coeliac disease. It is suggested that the release of IR-GIP and duodenal IRG is influenced by the rate of absorption of nutrients. In patients with chronic pancreatitis the IR-GIP release is significantly greater than in controls, the IRG release normal and the IRI response delayed. After Whipple's procedure the IR-GIP response is increased significantly while the IRG secretion is abolished. This demonstrates that the duodenum is not necessary for GIP release and that pancreatic and jejunal gastrin are without clinical significance.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 16 (1969), S. 0 
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract— 〈list xml:id="l1" style="custom"〉1Phosphatidylinositol hydrolase activity of homogenates of guinea pig brain was studied by using [2-3H]inositol labelled substrate and measuring the release of radioactivity into the acid soluble fraction.2Inositol phosphate and diglyceride were found to be the main hydrolysis products. The principal enzyme involved, therefore, is a phosphatidylinositol inositolphosphohydrolase.3Most of the enzymic activity (61 per cent) was found in the soluble fraction. Osmotic shock of the high speed particulate fraction resulted in release of an additional 23 1 per cent into the soluble fraction. However, as contrasted to lactate dehydrogenase, significant activity remained particulate bound.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1365-2761
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: The parasite, Anguillicola crassus is a non-native species that infects naive European eels, Anguilla anguilla, and causes pathological damage to the swimbladder, potentially compromising their ability to cope with hypoxic conditions. This study aimed to elucidate whether anguillicolosis exacerbates the stress responses to exposure to hypoxic water, conditions that have been implicated in mass mortalities of wild infected European eels. Blood parameters in infected and uninfected eels were measured during exposure to severe hypoxia over an 8-h period. Infected fish showed significantly higher levels of plasma cortisol compared with uninfected eels after 4 h of hypoxia. Uninfected fish showed an almost twofold increase in plasma glucose after 8-h exposure to hypoxia but infected fish showed no significant change, so that the plasma glucose concentration was significantly higher in uninfected eels than in infected eels. Both groups showed similar elevations in blood haematocrit, suggesting a similar catecholamine response in infected and uninfected eels. The lack of a hyperglycaemic response in infected eels, despite indirect evidence of a catecholamine response to hypoxia, may reflect an increase in glucose turnover. The data suggest that anguillicolosis results in a significantly greater corticosteroid stress response to hypoxia accompanied by a higher metabolic cost.
    Type of Medium: Electronic Resource
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