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  • 1
    Call number: YY Diss Berg/Mag
    Keywords: DKFZ-publications / academic dissertations
    Pages: 69 p.
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    YY Diss Berg/Mag departmental collection or stack – please contact the library
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of neurology 219 (1978), S. 205-212 
    ISSN: 1432-1459
    Keywords: Minimal brain dysfunction ; Minor nervous dysfunction ; Child behavior ; Learning disabilities ; Soft-signs
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung An 88 Schülern in dritten Volksschulklassen wurde eine Untersuchung zur Feststellung der Häufigkeit der Minor Nervous Dysfunction (Touwen und Prechtl) vorgenommen. Die Untersuchung umfaßt neben einer neurologischen und einer motoskopischen Untersuchung eine visuomotorische Leistungsprüfung (Einstecktest nach Gleiss). Es wurden folgende Ergebnisse gefunden: 1. Bei 15,9% der Kinder wurde der Verdacht auf Minor Nervous Dysfunction ausgesprochen. 2. Nur zwei Kinder zeigten optimale Leistungen im Sinne des Optimalitätskonzepts nach Prechtl. 3. Wird die Diagnose einer Minor Nervous Dysfunction gestellt, ohne Verhaltensauffälligkeiten als diagnostisches Kriterium einzubeziehen, so findet sich kein statistisch signifikanter Zusammenhang zwischen dem Zustandsbild der Minor Nervous Dysfunction und der schulischen Leistung bzw. dem Sozialstatus. 4. Der spezifische Charakter der von Lempp (1964) unter der Bezeichnung „frühkindliches exogenes Psychosyndrom“ beschriebenen Verhaltensauffälligkeiten erscheint aufgrund unserer Ergebnisse fraglich. Diese Verhaltensstörungen finden sich aufgrund der von uns verwendeten diagnostischen Kriterien ebenso häufig bei organischen Hirnfunktionsstörungen wie bei Kindern aus niedriger Sozialschicht.
    Notes: Summary A study was made on 88 third grade school children to determine the frequency of minor nervous dysfunction (MND) (Touwen and Prechtl). The study consisted of a neurological and an motoscopic examination as well as a visuomotor performance test (Gleiss). The following results were obtained: 1. Suspected MND was found in 15.9% of the population. 2. Only two children had optimal performance according to Prechtl's optimality concept. 3. If the diagnosis MBD is made excluding the behavioral description as a diagnostic criterion, no significant statistical correlation was found with school marks or social class. 4. The specific character of Lempp's “frühkindliches exogenes Psychosyndrom” and the behavioral disturbances described seems to us to be questionable. We found such disturbances with our methods as frequently in children with disturbed organic brain function as in children from a low social class.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-2013
    Keywords: Control of respiration ; Central chemoreceptors ; Carotid body ; Stimulus interaction ; Vagotomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In cats anesthetized with chloralose-urethane, the central respiratory chemoreceptors were exposed to mock CSF of pH 7.02, 7.20, or 7.57. The right carotid body was simultaneously stimulated by intracarotid injections of 40, 80, or 160 μg sodium cyanide in 200 μl Ringer solution. The left carotid nerve and, in some animals, both vagosympathetic truncs were dissected. It could be demonstrated the the increase in ventilation produced by application of NaCN to the peripheral chemoreceptors is significantly larger at high than at low mock CSF pH (i.e. at low than at high central stimulus intensity). In vagotomized cats the responses of VT and gelai to NaCN similarly depend upon CSF pH; they are somewhat larger, though, than in intact animals. These results are discussed as compared with results reported by different authors.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary α1-acid glycoprotein, a major human serum glycoprotein was detected and localized in human liver parenchymal cells of a biopsy specimen. A heavy metal salt containing fixative was required to retain sufficient antigen determinants of α1-acid glycoprotein in order to visualize this protein by the peroxidase-anti-peroxidase unlabeled antibody enzyme method.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Human genetics 〈Berlin〉 48 (1979), S. 13-16 
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A case of trisomy 6p21→6pter resulting from a maternal balanced t(2;6)(p25;p21) translocation is reported. The main clinical abnormalities were psychomotor retardation, hypotrophy, blepharophimosis, nystagmus, high nasal bridge, small mouth, sacral dimple, and systolic murmur. Other anomalies might have been due to partial 2p monosomy. Comparison with seven other cases of trisomy 6p allowed the delineation of a clinical entity. Direct proof of the localization of HLA genes was given by the presence of three haplotypes in the index patient.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A t(8;22)(q24;q11) translocation was found in blood, bone marrow, and ascites cells from a European Burkitt's lymphoma. Cell surface markers were identified as monoclonal IgG. The relationship between these two unusual findings is questionable in this cytologically typical Burkitt's lymphoma.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Cytogenetic and enzyme studies of a child trisomic for 6p and monosomic for band 2p25 are reported. A tentative assignment of the ACP 1 gene locus to band 2p25 is suggested by a 50% decrease in red cell acid phosphatase activity.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1432-0533
    Keywords: Capillary ; Maturation ; Human ; Cerebral Development ; Electron Microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The ultrastructural characteristics of the cerebellum and olfactory bulb capillaries were studied in 12 human specimen measuring 25–200 mm. Type I capillaries, whose lumina were wider than 8 μ contained no pores or fenestrations. The basement membrane was sometimes discontinuous. In that case, junctions without quintuple-layered zones could be observed. Such capillaries may correspond to primary vessels in which the sinusoid character has disappeared. Elsewhere, the basement membrane was continuous and the interendothelial junctions always contained quintuple-layered zones. Type II capillaries, whose lumina measured between 2 and 8 μ had basement membranes that were either discontinuous or continuous. They were identical to the immature capillaries described previously in numerous species including man. Type III capillaries, rarely observed, were characterized by the presence of several endothelial cells with abundant cytoplasm, which limited the lumina from 0.5–3 μ in diameters. They had continuous basement membranes. Type IV and V capillaries has small or non-patent lumina. The basement membrane was absent or rudimentary. These capillaries appeared to correspond to simple and complex endothelial sprouts. In Types II, III, V and most Type IV capillaries, the interendothelial junctions contained quintuple-layered zones. No mature capillaries were observed. The hypothetical pathways of development of cerebral capillaries and the degree of permeability of immature interendothelial junctions are discussed. The long duration of maturation in man probably accounts for the diversity of capillary formations observed as compared with animals. The co-existence over a long period of time of several capillary types with probably varying permeability may play a significant role in the maturation of the blood-brain barrier.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Diabetologia 11 (1975), S. 93-100 
    ISSN: 1432-0428
    Keywords: Diabetic coma ; ketoacidosis ; non-ketotic hyperosmolar coma ; acidosis ; mortality ; blood urea
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The admission data and the course of 58 episodes of severe diabetic ketoacidotic coma and of 28 episodes of non-ketotic coma are compared. The non-ketotic patients were older; initial blood glucose, osmolarity, blood urea and serum sodium concentration were higher than in the ketotic patients. Treatment in the first 24 hrs consisted of similar amounts of insulin in both coma forms, the presence of acidaemia did not increase the insulin needs. Acidaemia was corrected only when pH was below 7.20. The disadvantages of alkali therapy are emphasized. A comparison of the age groups of survivors and those patients who died within 72 hrs showed an increase in mortality with age. However, the mortality rates from ketotic and non-ketotic coma were similar in the age groups above 50 years. On admission, blood glucose, osmolarity and blood urea were higher in the fatal cases. Blood urea was the most important indicator of a fatal outcome. The response of blood glucose to insulin was impaired in the subsequently fatal cases. Insulin was given in “moderate” doses by constant infusion. The use of “small” doses is discussed. Early mortality was 14% in the ketotic and 29% in the non-ketotic cases. The most frequent causes of death were circulatory failure of undetermined origin, infections and thromboembolic complications.
    Type of Medium: Electronic Resource
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