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  • 1
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1106
    Keywords: Climbing fibers ; Mossy rosettes ; Bands
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The pathways and terminal projections of the inferior olivary complex and the lateral reticular nucleus (LRN) to the cerebellar nuclei and cortex in the rat were studied using unilateral and bilateral injections of 35S-methionine followed by light microscope autoradiography. The cerebellar projections from unilateral olivary injections show heavy contralateral, crossed and light, ipsilateral, uncrossed projections in sagittal bands in the deep nuclei and in the molecular layer. The crossed projections occupy all cortical lobules. Bilateral olivary injections that encompassed all subdivisions of the nuclear complex on both sides demonstrated that the same pattern of sagittal zonation is preserved although in this case distributed bilaterally. Thus, the representations of ipsilateral and contralateral projections of both sides overlap precisely and banding is preserved. These data suggest that the olivocerebellar climbing fibers occupy the banded areas and that the empty strips of molecular layer between them must have climbing fibers of extra-olivary origin. It was also found that climbing fiber rosettes are present in the granular layer borne by collaterals of axons en route to the molecular layer; their distribution is not restricted to the molecular layer bands. Unilateral injections in the LRN produced heavy, uncrossed, ipsilateral and light, crossed, contralateral projections with the crossing occurring in the cerebellum. Projections to the deep nuclei occur and the terminal arborizations in the cortex are dense fields of mossy fiber rosettes forming narrow sagittal bands restricted to the granular layer. These mossy fiber rosettes contrast sharply in their number and distribution to the climbing fiber rosettes. The data from these studies strengthen the evidence gathered from morphological and physiological studies that the entire cerebellum may be organized on a plan involving narrow sagittal strips with structural, functional and chemical significance.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A starch gel electrophoretic procedure is described that resolves peptidase S (PEPS) as well as the peptidases A, B, and C in man-rodent, rodent-rodent, and primate-rodent interspecific somatic cell hybrids. The interspecific PEPS cell hybrid phenotype can be resolved into a pattern which suggests that PEPS is composed of five or six identical subunits. Results are presented supporting assignment of the PEPS locus to chromosome 4 in man using man-mouse and man-Chinese hamster somatic cell hybrids. Human genes coding for peptidases A, B, C, and D were assigned to chromosome 18, 12, 1, and 19, respectively, confirming previous assignments. These somatic cell genetic data demonstrate the independent genetic control of the several human peptidases.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-1017
    Keywords: Calcium ; Limulus ; Photoreceptors ; Adaptation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Notes: Abstract Calcium ion fulfills several criteria for identifying an intracellular messenger for light-adaptation in Limulus photoreceptors. Direct injection of Ca++ mimicks two aspects of light-adaptation; sequestration of intracellular calcium tends to prevent light-adaptation; and light induces an increase in intracellular Ca++ as demonstrated by two independent techniques.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-1041
    Keywords: Tetracyclines ; half life ; volume of distribution ; renal clearance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The disposition of minocycline, tetracycline, doxycycline and oxytetracycline was investigated in four male volunteers after multiple dosing. Values for half life, renal clearance and volume of distribution were calculated and corrected for plasma protein binding. Tetracycline and oxytetracycline have a much larger volume of distribution than minocycline and doxycycline but similar half lives. They give higher tissue levels for equivalent plasma levels. Since their cost per unit dose is much lower they should be the tetracyclines of first choice.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Skeletal radiology 3 (1979), S. 250-253 
    ISSN: 1432-2161
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-0428
    Keywords: GIP ; gastrin ; insulin ; incretin ; chronic pancreatitis ; test meal ; malassimilation of fat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Twenty-nine patients with chronic pancreatitis had a significantly greater IR-GIP response to a test meal than 15 controls. This increased response was not related to the degree of steatorrhoea or glucose intolerance. It was most marked in a group of patients with moderately impaired IRI release and medium steatorrhoea. From this is concluded that the IR-GIP response to a test meal is determined by at least two factors: 1. feedback control via insulin secretion, 2. assimilation of fat. In chronic pancreatitis endocrine insufficiency may induce an exaggerated GIP response and severe exocrine insufficiency may prevent fat induced GIP release. Gastrin is not involved in the different GIP response in patients with chronic pancreatitis.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-0428
    Keywords: GIP ; gastrin ; insulin ; incretin ; coeliac disease ; duodeno-pancreatectomy ; chronic pancreatitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The response of serum immunoreactive gastric inhibitory polypeptide (IR-GIP), gastrin (IRG) and insulin (IRI) to a mixed standard meal was measured in 15 controls, 6 patients with coeliac disease, 26 patients with chronic pancreatitis and 6 patients with chronic pancreatitis and partial duodenopancreatectomy (Whipple's procedure). Serum levels of IR-GIP, IRG and IRI were significantly reduced in patients with coeliac disease. The serum glucose increase was significantly smaller only during the first hour after the meal. Since small intestinal GIP- and G-cells are situated mainly in the glands of duodenal and jejunal mucosa their absolute number is not significantly reduced in coeliac disease. It is suggested that the release of IR-GIP and duodenal IRG is influenced by the rate of absorption of nutrients. In patients with chronic pancreatitis the IR-GIP release is significantly greater than in controls, the IRG release normal and the IRI response delayed. After Whipple's procedure the IR-GIP response is increased significantly while the IRG secretion is abolished. This demonstrates that the duodenum is not necessary for GIP release and that pancreatic and jejunal gastrin are without clinical significance.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 99 (1978), S. 0 
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Griseofulvin was tested for its effects on the morphology, proliferation and metabolism of fibroblasts cultured from normal human skin and on established lines of mouse fibroblasts 3T3 and 3T6. In all cells treatment produced slight increases in the mitotic index compatible with transient mitotic arrest, but cultures of 3T3 and 3T6 cells also included high proportions (up to 25%) of abnormal multi-nucleate cells not present in human strains. The proliferation of all cell strains over a 2 or 4 day period was inhibited in proportion to dose (2–17 μg/ml) with 50% inhibition of growth in the range of 5-11 μg/ml. Acid mucopolysaccharide secretion was depressed by about 20% at 4–17 μg/ml. Total protein synthesis was depressed in 3T6 and in human cells, but there was no specific effect on collagen synthesis or secretion.
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  • 10
    ISSN: 1365-2761
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Abstract. An in vitro technique was developed to screen drugs for toxicity to laboratory cultured protozoans. Drugs were diluted using standard microtitration equipment. An easily cultured protozoan, Tetrahymena pyriformis, was added to the dilutions of drugs and viability was checked daily for 10 days. Drugs used as a model system to test the technique were formalin and malachite green. Effective concentrations of formalin determined by this in vitro technique were close to recommended therapeutic treatment levels for Ichthyophthirius. Malachite green was effective at concentrations in excess of recommended therapeutic treatment levels for Ichthyophthirius. The synergistic effect of formalin and malachite green was demonstrated. This technique can he of use in determining effectiveness of new drugs as parasiticides.
    Type of Medium: Electronic Resource
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