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  • 1
    ISSN: 1432-1041
    Keywords: Terbutaline ; ibuterol ; dose response curves ; forced expiratory volume ; side effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The selectivity of the recently developed β-stimulating drug ibuterol, a terbutaline ester which is rapidly hydrolyzed to terbutaline in vivo, was tested by comparing it with terbutaline after intravenous infusion. Dose-response curves for both drugs for FEV*1, heart rate, blood pressure, and tremor were recorded. The two drugs had equal bronchodilator effect. Ibuterol caused significantly less increase in heart rate, tremor ratio, and pulse amplitude when doses causing equal bronchodilation were infused. This is probably due to inequality of distribution. The lower tremorogenic activity of ibuterol can also be caused by differences in the concentration of tissue esterases in lung and skeletal muscle. It is concluded that ibuterol is more selective for the bronchi than terbutaline.
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  • 2
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Soixante-dix-sept (77) patients porteurs d'hémophylie A ou B furent soumis à un total de centhuit (108) opérations chirurgicales majeures relevant principalement de la chirurgie générale, de la chirurgie orthopédique ou de la neurochirurgie. L'article décrit les principes guidant le remplacement des facteurs anti-hémophyliques selon les différents types d'hémophylie et d'intervention ainsi que les indications opératoires et la technique chirurgicale. On y souligne l'importance de prolonger la thérapie de substitution durant la période post-opératoire pour éviter la formation d'hématome tardif, en particulier chez les cas d'hémophylie grave soumis à des interventions chirurgicales majeures. Grâce au traitement employé, on a évité les hemorragies peropératoires et quelques rares cas seulement d'hématomes post-opératoires ont été observés. En combinant le remplacement des facteurs anti-hémophyliques et l'immunosuppression, mÊme les patients porteurs d'inhibiteurs des facteurs VIII et IX ont pu Être opérés. Le taux de complication, en particulier l'incidence d'hépatite, est demeuré bas. En conclusion, l'hémophylie mÊme sévère est compatible avec la chirurgie majeure et ce, sans augmentation significative du risque opératoire. Cependant, l'application du traitement de substitution de mÊme que le jugement et la technique chirurgicale posent des problÊmes importants qui nécessitent la centralisation des cas électifs.
    Notes: Abstract Seventy-seven hemophilic patients of type A or type B were subjected to a total of 108 major surgical procedures mainly in the field of general surgery, orthopedic surgery, or neurosurgery. The principles for the substitution therapy in the different types of procedures and different types of hemophilic diseases are described, as well as the indications for surgery and the surgical technique. The importance of prolonged substitution therapy postoperatively to avoid late hematoma, particularly in patients with severe hemophilia undergoing major surgery, is stressed. With this type of management there has been no increased intraoperative hemorrhage, and very few cases of late hematoma formation. By combining the substitution therapy with immunosuppression, it has been possible to operate also on patients with inhibitors against factor VIII or IX. The rate of complications, particularly the incidence of hepatitis, has been low with the type of substitution given in this series of patients. It is concluded that major surgery can be carried out even in severe hemophilia without significantly increased risk. The handling of the substitution therapy, and the surgical judgment and technique, offers however, special problems, necessitating centralization of elective cases.
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  • 3
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract A detailed analysis of the positive parity levels in odd iridium isotopes is carried out with an extended version of the Hecht and Satchler model. A satisfactory description of187–193Ir positive parity states and their electromagnetic properties is obtained by coupling several Nilsson particle configurations to an asymmetric rotor.
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  • 4
    ISSN: 1432-0827
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary An ion micro-analyzer (Cameca IMS 300 with a TD 1000 computer unit) has been calibrated for quantitative point determination of fluorine in apatites, including tooth and bone material. Samples with macroscopically measured F concentrations were used as external standards. The samples were bombarded with O− primary ions. Secondary positive ion currents were registered as mass spectra containing mass numbers 19, 20, 31, 44, 59, 60 and 61. The latter mass numbers were used in isotopic correction to subtract oxide and hydroxide contributions from the fluoride 59 peak. For each bombarded spot, the ratios19F+/40Ca2+, respectively59CaF+/44Ca+, were plotted in a log-log graph against40Ca2+/44Ca+, the abscissa providing a measure of ionization efficiency. The plots yielded two sets of parallel straight lines, with ordinate values proportional to the respective F/Ca concentration ratios, in agreement with earlier theory. Each set of lines constitutes a calibration graph, where the fluorine concentration at an investigated spot is obtained when substituting the measured ion current ratios. With biological apatites, account must also be taken of effects due to, among other things, adsorbed humidity, other contaminations, and non-stoichiometry. When all precautions are taken, the accuracy of the determined F contents in the point analysis of an area some 100 μm in diameter can be expected to be better than 6% at 1500 ppm F, and better than 25% at 100 ppm F. The calibration is effective down to about 20 ppm F. Applications have been carried out on samples of human tooth enamel.
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  • 5
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Letalität bei Listeriose-Meningitis und -Sepsis, den beiden Hauptmanifestationen der Infektion, ist nach allgemeiner Ansicht hoch. Jedoch scheinen eher die Begleiterkrankungen als die Listeriose-Infektion selbst den Ausgang der Erkrankung zu bestimmen. In der vorliegenden Studie an 72 Fällen mit Listeriose-Infektion bei nicht schwangeren Erwachsenen betrug die Letalität bei 28 Patienten ohne Begleitkrankheit 10,7%, bei 19 Patienten mit gestörter Immunität hingegen 57,9%. In einer dritten Gruppe von Listeriose-Kranken, die Alkoholiker, Patienten mit Herzerkrankungen und Diabetes mellitus einschloß, lag die Sterberate bei 24,0%.
    Notes: Summary The mortality in listeric meningitis and septicaemia, the two main clinical manifestations of the infection, is generally considered to be high. However, co-existing disorders rather than the listeric infection itself seem to determine the outcome. In the present study of 72 listeric infections among non-pregnant adults, 28 patients without co-existing disease had a fatality rate of 10.7% as compared to 57.9% among 19 immunocompromised individuals. Finally, in a third group of listeric patients, including alcoholics and people with heart disease or diabetes mellitus, the fatality rate was 24.0%.
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  • 6
    ISSN: 1573-2584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Serum hepatitis is a dreaded risk in connection with regular dialysis treatment (RDT). Liver damage, however, can be caused by other diseases, such as infection with cytomegalovirus (CMV). Two cases in our artificial kidney unit revealed signs of liver damage with increased liver enzyme activity. Case 1, a woman, was on RDT after an unsuccessful renal transplantation, and Case 2, a man, belonged to the staff. Serum hepatitis was initially suspected in both cases, but repeated examinations of the sera revealed no hepatitis B antigen or antibodies (HbAg and HbAb). Later on, both showed a significant increase in antibodies in complement fixations reaction (CF) to CMV-antigen. CMV could be isolated from urine in Case 2. Case 1 had been bilaterally nephrectomized. The symptoms (tiredness, muscle pain and headache) and the course of the disease were mild in both cases and liver enzymes became normal within 1–2 weeks. Twenty out of 31 examined patients and staff had antibodies in CF to CMV-antigen, but in none was there any significant increase. The source of infection may have been transfusion of fresh blood in Case 1, but in Case 2 no particular source could be suspected. Thus, in liver damage CMV-infection may be an etiological alterative. In routine work at artficial kidney unite patients and personnel are regularly examined in respect of bilirubin, liver enzymes, HbAg and HbAb in serum. We recommend also examination of serum for antibodies in CF to CMV-antigen. Until a firm differential diagnosis has been established the patient should be isolated and the dialysis equipments used only by that patient.
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  • 7
    ISSN: 0020-7608
    Keywords: Computational Chemistry and Molecular Modeling ; Atomic, Molecular and Optical Physics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: It is shown that multiple scattering Xα calculations on Ni(CO)4 predict a strong back-donation effect contrary to what is stated in previous papers on the subject.
    Additional Material: 2 Ill.
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  • 8
    Electronic Resource
    Electronic Resource
    New York, NY : Wiley-Blackwell
    ISSN: 0020-7608
    Keywords: Computational Chemistry and Molecular Modeling ; Atomic, Molecular and Optical Physics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The Hartree-Fock and first natural spin determinants were compared as reference determinants for calculating various one-electron properties such as ρ(0), 〈½∇〉, 〈r-2〉,…, 〈r3〉, and r-112〉. Calculations were made on various small atoms and their positive and negative ions. For nearly all the expectation values studied, the first natural spin orbital determinant gave consistently superior results. In particular, the Hartree-Fock functions gave markedly inferior results for some long range properties such as the magnentic susceptibilities of negative ions. The major correlation error in the expectation values is primarily an orbital effect which may be accounted for by including correlation terms in the one-particle Hamiltonian. Such approximate Brueckner or best overlap orbitals should reproduce most one-electron expectation values accurately.
    Additional Material: 2 Tab.
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