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  • 1985-1989  (4)
  • 1970-1974  (6)
  • 1
    ISSN: 1432-069X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Im Röntgenbild von Gewebsschnitten (Mikroradiogramm, Histioradiogramm) wird das Verhalten des Haarfollikels, des Haares und der übrigen Haut während eines künstlich induzierten Haarcyclus bei der Maus studiert. Die Ergebnisse am Haarfollikel und Haar sind in der Tabelle zusammengefaßt (0=keine Strahlendurchlässigkeit, 4=völlige Strahlendurchlässigkeit der Strukturen). Die Verbreiterung der Epidermis im Anagen entspricht einer echten Proliferation, Cutis und Subcutis sind aufgrund einer Materialverdünnung und nicht einer Materialzunahme verbreitert. Deutlich ist am Ende des Katagen um das Haar das Gebilde zu beobachten, welches Kligman als “Hair-Cast” bezeichnete.
    Notes: Summary X-ray microradiograms were prepared from histological sections of mouse skin after artificial induction of the hair cycle. The results on hair and hair follicle are graded according to X-ray penetrability (0=no penetrability, 4=complete penetrability). In anagen the epidermis is thickened and less permeable for x-rays, whereas cutis and subcutis are more permeable. Hair casts become visible around the hair shafts at the end of katagen.
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  • 2
    ISSN: 1432-069X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Im Talgdrüsennaevus machen die Talgdrüsen die Entwicklung im Kindesalter mit, d. h., sie werden nach dem 2. Lebensjahr zurückgebildet. Bei der Pubertät entwickeln sich die Talgdrüsen wieder voll, sezernieren aber wahrscheinlich zum großen Teil nicht. Neben der Mißbildung der Talgdrüsen werden auch Fehlanlagen der apokrinen Drüsen und besonders reichlich fehl angelegte Haarfollikel gefunden. Während der Phase der Rückbildung steht die Epidermishypertrophie im Vordergrund. Es ist daher möglich, den Talgdrüsennaevus als Oberhautnaevus zu verkennen.
    Notes: Summary The sebaceous nevus is actually an organoid nevus. The sebaceous glands in the nevus follow the pattern of the normal sebaceous glands during infancy. In the first year of life they are fully developed and secreting. After the first year their size is reduced, and at puberty they are fully developed again, but possibly do not secrete sebum. During the regressive phase between the first year of life and puberty, the sebaceous glands may be overlooked. Since the hypertrophy of the epidermis predominates, sebaceous nevus may be misdiagnosed as verrucous epidermal nevus.
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  • 3
    ISSN: 1432-069X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In zwei vorausgegangenen Testreihen zeichnete sich ein bestimmtes enzymhaltiges Waschmittel durch besonders häufige und deutlich positive Läppchentests aus. Um diesem Befund weiter nachzugehen, führten wir Läppchentests mit zwei verschiedenen enzymhaltigen und einem enzymfreien Waschmittel in der Zeit vom 14. 9. 1970 bis 31. 12. 1971 bei 946 Probanden aus (0,5%ige wäßrige Lösung, Ablesung nach 24, 48 und 72 Std). Bei 542 der Probanden wurden auch die Enzyme Alcalase und Maxatase in 0,015%iger Lösung getestet. Auf das enzymhaltige Waschmittel 1 reagierten 134 Probanden = 14,2% positiv, auf das enzymhaltige Waschmittel 2 60 Probanden = 6,3% und auf das enzymfreie Waschmittel 46 = 4,9%. Überraschenderweise nahm die Zahl der positiven Reaktionen im Verhältnis zur Zahl der Getesteten während der Beobachtungszeit stetig ab. Von den 542 Probanden, bei denen die Enzyme Alcalase und Maxatase mitgetestet wurden, zeigten 38 (= 7%) eine positive Reaktion. Auf Alcalase reagierten 29 Probanden (= 5,6%) positiv, auf Maxatase 27 Probanden (= 5,2%). 11 Patienten zeigten eine positive Reaktion nur beim Test mit Alcalase und 9 Patienten nur beim Test mit Maxatase. Auffallend war bei den Probanden der hohe Anteil von Männern, die im Läppchentest mit den Waschmittelenzymen positive Reaktionen zeigten.
    Notes: Summary In two previous test series one particular enzyme-containing washing powder (No. 1) produced far more positive patch tests compared to a second (No.2) with enzymes and a third (No.3) without. In order to substantiate these findings, we conducted further patch tests using two different powders with proteolytic enzymes (alcalase and maxatase) and one without. Between September 14th 1970 and December 31st 1971, 946 patients were patch tested with the three compounds in a 0.5% aqueous solution. Readings were taken after 24, 48, and 72 h. Also, 542 patients were patch-tested with the enzymes alcalase and maxatase in a 0.015% aqueous solution. 134 patients (=14.2%) reacted positively to the biological washing powder No. 1; 60 patients (= 6.3%) reacted positively to the biological washing powder No. 2; and 46 patients (= 4.9%) reacted positively to the washing powder No. 3 (without enzymes). Surprisingly, the number of positive reactions in relation to the number of patients tested decreased constantly during the period of observation. We feel that this may be due to improvement of the washing powders themselves. 38 out of 542 patients (= 7%) reacted positively to the enzymes alcalase and/or maxatase. 29 (= 5.6%) reacted positively to alcalase, and 27 (= 5.2%) to maxatase. 11 patients reacted only to alcalase, and 9 only to maxatase. When our tests began, there were more positive reactions amongst female patients, but later there were more positive reactions amongst male patients. This pattern of positive reaction may be due to German habits of dress and the distribution of household duties in Germany.
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  • 4
    ISSN: 1432-069X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Autoradiographische in vitro-Untersuchungen gesunder und psoriatisch veränderter Haut mit dem Doppelmarkierungsverfahren (1 µC C-14-Thymidin und 10 µC H-3-Thymidin) ergaben bei unbehandelter psoriatischer Haut einen entsprechend der gesteigerten Proliferationsaktivität auf durchschnittlich 8,83% erhöhten Thymidinmarkierungsindex. Die Generationszeit war verkürzt. Unter der durchgeführten Dithranol-Saliclysäure (10%)-Vaseline-Behandlung (DSP) kam es entsprechend dem klinischen Verlauf zu einer Normalisierung des Markierungsindex und zu einer Verlängerung bzw. Normalisierung der Dauer des Zellcyclus. Nach den erhaltenen Ergebnissen scheint ein Einfluß der Dithranol-Salbe auf die DNS-Synthese zu bestehen.
    Notes: Summary Autoradiographic in vitro-examination of normal and of psoriatic skin, using the double labelling technique (1 µC thymidine-2-C14 and 10 µC thymidine-methyl-H3), revealed the usual increase of proliferative activity in psoriatic skin, approximately four times greater than normal. The cell cycle time was shortened. According to the data obtained by the double labelling technique a shortening of the DNA synthesis time was not found in vitro. Treatment with a dithranol-salicylic acid (10%)-petrolatum ointment (DSP) normalized the cell cycle in accordance with the degree of clinical improvement. The findings seem to indicate that DSP has an effect on the DNA-synthesis.
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  • 5
    ISSN: 1432-069X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wird über vergleichende Untersuchungen von Epi- und Intracutantestungen mit Metallsalzen von Chrom, Kobalt, Kupfer und Nickel (CrO3, K2Cr2O7, CoSO4 ⋅ 7H2O, CuSO4 und NiSO4) an 132 Patienten berichtet. Bei 4 Patienten fand sich bei negativem Epicutantest eine positive Spätreaktion auf die Intracutantestung 1:10000. Bei 4 weiteren Fällen, die auf eines oder mehrere Metalle im Epicutantest reagierten, traten im Intracutantest noch zusätzlich positive Reaktionen auf andere Metallsalze auf. Eindeutig positive Epicutantests in der üblichen Konzentration stimmten mit positiven Epicutantests in einer 10fachen Verdünnung und mit den positiven Spätreaktionen im Intracutantest in einer Konzentration 1:10000 überein; „positive“ Epicutantests bei negativer Spätreaktion im Intracutantest kamen jedoch vor 1. bei Patienten mit Endogenem Ekzem, 2. bei Patienten, die noch im akuten Stadium ihres Ekzems getestet worden waren, 3. bei Patienten, die bei einem stark positiven Epicutantest auf eine andere Substanz eine Mitreaktion auf Metallsalze zeigten. Wegen der zahlreichen unspezifischen Sofortreaktionen kann ihre Beurteilung nur im Zusammenhang mit den Spätreaktionen erfolgen. Bei 11 Patienten wurde als Komplikation des Intracutantestes ein Aufflammen ferngelegener Ekzemherde beobachtet. Die Intracutantests mit Metallsalzen haben ihre Bedeutung als Ergänzungstests zum Routine-Epicutantest: 1. zum Aufdecken von Metallallergien bei negativem Epicutantest und positiver Anamnese, 2. zur Differenzierung einer „ekzematös allergisch positiven“ von einer „unspezifisch positiven“ Epicutantestreaktion.
    Notes: Summary Patch tests and intracutaneous tests with metal salts (CrO3, K2Cr2O7, CoSO4 ⋅ 7H2O, CuSO4, and NiSO4) were performed in 132 patients. In four patients, intradermal testing with a 1:10000 diluted antigen solution revealed a positive delayed reaction, although the patch test had been negative. Four other cases which reacted to one or more metals in the patch test showed additional positive delayed reactions to other metal salts when tested intradermally. Patch testing with the usual antigen concentration also gave positive results with the antigen diluted ten times as well as in intracutaneous tests (1:10000 dilution). Positive patch test reactions however, with negative delayed intradermal response occured 1. in patients with atopic dermatitis, 2. in patients in an acute phase of exzema and 3. in cases with contact allergies to other compounds, which showed a weak reaction to metal salts. Because immediate, non-specific reactions to intracutaneous tests were numerous, these reactions were of significance only in connection with delayed reactions. In 11 cases, exzematous lesions flared up at some distance from the site of the intracutaneous test. We feel that such intracutaneous tests should not be conducted routinely, but only in order to supplement routine patch testing: 1. for detecting allergies to metals in cases with a positive history but negative patch tests and 2. for distinguishing specific from non-specific patch tests.
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  • 6
    ISSN: 1432-069X
    Keywords: Kaposi's sarcoma ; Initial lesion ; HIV infection ; Spindle cells ; AIDS
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Kaposi's sarcoma (KS) in human immunodeficiency virus infection (HIV) has become a rather frequent manifestation of the previously rare disease with fatal outcome. Initial lesions of KS were studied by means of histopathology, immunohistology, and electron microscopy in order to define the earliest alterations. The histopathological changes of initial lesions were distinct, consisting of (1) discrete proliferation of capillary vessels, (2) dissection of collagen by proliferating spindle cells which formed slits, (3) atypical spindle cells arranged in an Indian file pattern, and (4) the lack of any inflammatory cellular infiltrate. Double staining with antibodies against vimentin and immunohistochemical markers for endothelial cells revealed that slits forming vimentin-positive spindle cells displayed laminin, factor VIII, and PAL-E. Atypical vimentinpositive spindle cells arranged in an Indian file pattern inconsistently expressed laminin and factor VIII, but not PAL-E. KS cells rarely stained with the lectin UEA I, not even in case of less advanced dedifferentiation. Electron microscopy showed gradual transformation between spindle cells forming slits and those having lost the ability to form incomplete vessel walls. The present findings support the view that KS develops from the endothelial cells of the blood vessels. The proliferation of atypical endothelial cells as early as in initial lesions and the lack of inflammation favors the primary neoplastic genesis of KS.
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  • 7
    ISSN: 1432-069X
    Keywords: Arylhydrocarbon-hydroxylase (AHH) ; Epidermal cells ; Cell proliferation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Cytochrome P-450-dependent arylhydrocarbon-hydroxylase (AHH) activity and inducibility by benzanthracene (BA) was measured in cultured guinea pig and human epidermal cells. Basal AHH-activity (AHHb) in guinea pig epidermal cells was much higher than in human epidermal cells. AHHb in guinea pig epidermal cells was directly related to the labeling index and decreased to the original level between the 5th and 7th day of cell culturing. On the other hand, the induction-ratio of AHH reached its maximum level when the number of cells began to rise (proliferation phase) and remained high at day 7 of the cell culture. These results suggest a cell growth dependent activity and inducibility of carcinogen-metabolizing enzymes, such as AHH, in isolated epidermal cells.
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  • 8
    ISSN: 1432-069X
    Keywords: Psoriasis ; Polymorphonuclear leukocytes ; Myeloperoxidase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The specific activity of myeloperoxidase (MPO), an enzyme located in the primary granules of polymorphonuclear leukocytes, was measured in patients with psoriasis vulgaris and compared with that in patients with atopic dermatitis and in healthy subjects. MPO catalyzes the oxidation of guaiacol into tetraguaiacol in the presence of H2O2. The activity was determined by photometric measurement of tetraguaiacol. The specific MPO activity showed no statistically significant difference between the healthy subjects and the patients with atopic dermatitis. In comparison to these two groups the specific MOP activity of the psoriatic patients showed a slight reduction which was, however, not statistically significant.
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Archives of dermatological research 239 (1971), S. 414-425 
    ISSN: 1432-069X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Mit verschiedenen Techniken wird versucht, die Natur der lichtbrechenden Granula (Parakeratosegranula) zu bestimmen, die sich mit Sudanschwarz anfärben und besonders reichlich in der hyperkeratotischen Hornschicht vom psoriasiformen Parakeratosetyp vorkommen. Es gelingt nicht, einen Anhaltspunkt dafür zu erbringen, daß die Parakeratosegranula gebundene Lipide enthalten. Offensichtlich werden mit Sudanschwarz, jedenfalls bei den von uns vornehmlich angewandten Spezial verfahren, auch andere Stoffe außer Lipiden dargestellt, z. B. Nucleinsäuren; aber auch RNase und DNase widerstanden die Parakeratosegranula. Die Befunde bei verlängerter Sudanschwarz-Färbetechnik und der Flambierungstechnik mit Sudanschwarz an normaler Haut sind in der Tabelle zusammengestellt. Als Nebenbefund ergab sich in Ergänzung früherer Untersuchungen, daß auch im unfixierten Kryostatschnitt Zellkerne, einmal in die Hornschicht gelangt, für Desoxyribonuclease nicht mehr oder nur vermindert angreifbar sind. Diese Feststellung gilt auch für die Kerne von Leukocyten.
    Notes: Summary With different techniques, especially the Berenbaum acetone-sudanblack method for bound lipids and the Berenbaum burnt sudanblack method, an attempt, was made to determine the substrate of the parakeratotic granules. These parakeratotic granules are defined as double refractile granules which stain with sudanblack. They are especially common in the parakeratotic horny layer of the psoriatic type. No proof was found that the granules contain lipids. An unsuccessful attempt was also made to extract the granules or to digest them by DNase or RNase. With the above-mentioned techniques, nucleid acids and other substrates were also stained by sudanblack B. The results obtained in normal skin are found in the table. DNase digests the nuclei in the deeper epidermis, but nuclei remain in the perakeratotic horny layer. This was found to be true not only of the nuclei in the epidermis but also of the nuclei in the leucocytes in microabscesses of the horny layer.
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  • 10
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cutaneous pathology 12 (1985), S. 0 
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A survey of conditions with mucinous deposits is given. The most important factors for their diagnosis are to consider these disorders and to stain the slides for proteoglycans or glycosaminoglycans; the most common routine techniques are the Giemsa and the Alcian-blue stain. More sophisticated methods allow differentiation between specific compounds, especially hyaluronic acid and various pro-teglycans.
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