Springer Online Journal Archives 1860-2000
Abstract The influence of the vasoactive catecholamines, epinephrine and norepinephrine, has been investigated in regard to the comparative ulcerogenicity on the gastric glandular mucosa of the rat. The unique extensive, hemorrhagic necrosis, and ulcerations which appear in the fundus—but not the antrum—following single injections of these drugs are readily quantified because of the continuous nature of the lesion. A standard assay has been developed with this new ulcer model, which results in extensive mucosal ulceration (43% of fundus with lesions) in 100% of treated animals after only 5 hr. The optimal procedure requires the single intraperitoneal epinephrine injection of 0.4 mg/kg to young adult Sprague-Dawley rats 4 hr after pylorus occlusion, and the sacrifice of animals 1 hr after injection. This experimental gastric lesion is dependent upon the presence of gastric acid, and is completely inhibited by bilateral vagotomy, and almost completely inhibited by the presence of a magnesium-aluminum hydroxide gel-type antacid.
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