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  • 1980-1984  (7)
  • 1970-1974  (19)
  • 1955-1959  (806)
  • 1925-1929  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-2307
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The localization of CEA in gastric carcinomata of different histological types was studied by indirect immunofluorescence. In well differentiated adenocarcinomata CEA was present on the surface of the tumor cells. CEA was absent in anaplastic cancers. Signet ring cells contained both CEA and mucus in their cytoplasm; this may indicate that signet ring cells are fairly well-differentiated tumor cells. In areas with intestinal metaplasia, CEA was detected on the luminal surface of the cells similar to a malignant tumor.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-2307
    Keywords: Angioblastic Meningioma ; Hemangioblastoma ; Hemangiopericytoma ; Specific Red Cell Adherence ; Endothelial Cell ; Interstitial cell ; Pericyte
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The presence of blood group isoantigens in vascular endothelium cells was used in order to identify cells of endothelial origin in CNS tumors. 70 cerebrospinal tumors coded as “angioblastic meningiomas” and 30 cerebellar hemangioblastomas were examined for the detection of BG isoantigens by the specific red cell adherence (SRCA) test by Davidson (1972). In cerebellar and supratentorial hemangioblastomas a positive SRCA reaction in endothelial cells forming the prominent component of this neoplasm was opposed by a negative reaction in the large majority of interstitial (stroma) cells that argues against their endothelial origin. Identical behavior of SCRA test supports the histogenetic identity of hemangioblastomas and angioblastic meningiomas. A consistently negative SRCA reaction in cerebrospinal hemangiopericytomas except for the endothelial cells lining the capillaries supports the concept of a non-endothelial (pericytic) histogenesis of this neoplasm. Richly vascularized meningiomas with positive SRCA reaction restricted to vascular endothelial cells can be separated from angioblastic meningiomas, although transition forms are likely to occur. Angioblastic meningiomas suggested to originate from vasoformative elements (endothelium and pericytes) were found to represent 3.2 percent of a biopsy sample of 660 cases with cerebrospinal meningiomas. Their relationship to primary meningeal neoplasms needs further elucidation.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-2307
    Keywords: Carcinoid ; Immunocytochemistry ; Cytokeratin ; Neuron specific enolase ; Histogenesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Occurrence and distribution of cytokeratin, neuron specific enolase (NSE) and actin were studied by the immunoperoxidase-antiperoxidase (PAP)-technique using specific antibodies in formalin-fixed, paraffin-embedded material from 6 cases of neurogenic appendicopathy with numerous endocrine cells in the mucosal stroma (SEC), 5 cases of microcarcinoidosis of the stomach, 12 gastrointestinal carcinoids and 4 bronchial carcinoids. Cytokeratin was detectable in all tumor cells. In addition, the epithelial endocrine cells (EEC) and the SEC of intestinal origin were cytokeratin positive. EEC, SEC and cells of microcarcinoids and carcinoids showed a positive immunoreactivity with antibodies to NSE, whereas actin antibodies did not reveal significant staining of these cells. These results strongly suggest that carcinoids of the gastrointestinal tract originate from SEC that have migrated downwards into the stroma from the epithelial layer (“Endophytie” according to Feyrter).
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-2307
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Auftreten und Lokalisation eines aus normaler Colonmucosa mit Perchlorsäure extrahierbaren Antigens (NC) in benignen und malignen Colontumoren wurden mittels indirekter Immunfluorescenz untersucht und mit dem carcinoembryonalen Antigen (CEA) verglichen. In der normalen Dickdarmschleimhaut trat das NC intracellulär im sekretorischen Anteil der Becherzellen, extracellulär diffus im Schleim auf. Es kann somit als Schleimantigen angesehen werden. In Tumoren fand es sich unabhängig vom Differenzierungsgrad immer im intra- und extracellulären Schleim. In hochdifferenzierten Tumoren wurde es reichlich in Zellen gefunden, die normalen Becherzellen ähnelten. Diese Zellen sezernierten NC ins Lumen. Bezüglich des NC verhält sich der Schleim verschiedener Tumoren und der normalen Schleimhaut gleich. Es zeigt sich deutlich, daß die vom Differenzierungsgrad des Tumors abhängige CEA-Produktion von der Schleimproduktion und vom Auftreten des NC unabhängig ist. Entgegen früheren Befunden konnte CEA auch in Polypen und in der normalen Schleimhaut in der Umgebung von Carcinomen nachgewiesen werden, womit die Befunde von Burtin et al. (1972a) bestätigt werden.
    Notes: Summary Occurrence and localization of the carcinoembryonic antigen (CEA) and of a perchloric acid-soluble antigen of normal colonic mucosa (NC) were compared in polyps and carcinomas of the colon using the indirect immunfluorescence technique. NC is located in the secretory part of the goblet cells and diffusely distributed in the mucus. Therefore, it can be considered as a marker of large-bowel mucus. NC is found in all mucus-producing tumors regardless of their degree of differentiation in intra- and extracellular mucus deposits. Tumor cells which closely resemble normal goblet cells produce and secrete NC. With respect to their NC content, there is no immunologically detectable qualitative difference between the secretions of normal and of neoplastic large bowel mucosa. It is clearly shown that production and secretion of CEA is independent of mucus production and secretion. In contrast to earlier results, CEA was found in polyps and in normal mucosa surrounding the carcinoma, confirming the observations of Burtin et al. (1972a).
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  • 7
    ISSN: 1432-2307
    Keywords: Immunohistochemistry ; Pituitary gland ; Pituitary adenomas ; Cytokeratins ; Intermediate filaments
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Ten non-neoplastic pituitary glands and 22 pituitary adenomas producing different hormones were studied by immunofluorescence microscopy as well as peroxidase-antiperoxidase and biotin-avidin techniques on frozen sections and formalin-fixed, paraffin-embedded material using antibodies to cytokeratin, vimentin, GFAP, neurofilament protein and different pituitary hormones. The endocrine cells in non-neoplastic pituitary glands as well as in most pituitary adenomas were cytokeratin-positive. The cytoplasmic cytokeratin distribution patterns of non-neoplastic and tumor cells were similar and typical of the type of hormone produced: GH-producing normal cells showed a paranuclear condensation of cytokeratin-reactive intermediate filaments; this accumulation was even further accentuated in GH-producing adenomas resulting in fibrous bodies (Kovacs and Horvath 1978) decorated by cytokeratin antibodies. Prolactin-producing cells showed a less intense cytoplasmic cytokeratin-specific staining with focal paranuclear accentuation in non-neoplastic as well as in neoplastic glands. ACTH-producing cells in normal pituitary glands as well as in adenomas exhibited a strong and more uniform cytoplasmic cytokeratin staining. The cytokeratin reactivity in glycoprotein hormone-producing cells of non-neoplastic tissue and adenomas was weak. Vimentin and GFAP reactivity was confined to agranular folliculo-stellate cells. The specific and different distribution patterns of cytokeratins in pituitary cells can, therefore, provide an (indirect) indication to the production of a specific hormone if immunocytochemistry fails to demonstrate hormone production.
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  • 8
    ISSN: 1432-0533
    Keywords: Immunohistochemistry ; Folliculo-stellate cells ; Pituitary gland ; Pituitary adenoma ; S-100 protein
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Presence and distribution of S-100 protein (S-100), neuron-specific enolase (NSE), cytokeratin polypeptides, glial fibrillary acidic protein (GFAP), vimentin, actin, lysozyme and pituitary hormones (prolactin, hGH, ACTH, β-FSH, β-LH, β-TSH, alpha subunit) in folliculo-stellate cells (FSC) were studied in seven normal human pituitary glands and 28 pituitary adenomas using peroxidase-antiperoxidase and the avidin-biotin immunohistochemical techniques. Approximately 5% of the cells of the adenohypophysis were agranular, non-hormon-producing FSC most of which showed a conspicuous and strong reaction with S-100 antibodies but some were, in addition, GFAP- and vimentin-positive. In contrast to endocrine cells (EC), FSC were not decorated by antibodies to NSE or cytokeratins. In addition to supportive functions, these cells, due to their close special relationship to EC, seem to have transport and other metabolic functions yet to be elucidated. By their S-100 reactivity and their distribution FSC are comparable to glial cells of the central and schwann and satellite cells of the peripheral nervous system (PNS) as well as to supportive cells in neuroendocrine organs and related tumors (e.g., pheochromocytomas, paragangliomas, carcinoids). With one exception, S-100 reactive FSC were not found in pituitary adenomas. The immunohistochemical demonstration of S-100 protein in pituitary tissue is, therefore, a reliable aid in the discrimination between adenomas and normal pituitary tissue, particularly in small and poorly preserved specimens. In one adenoma FSC were found in addition to ACTH-producing tumor cells. This seems to be an extremely rare event suggesting a combination tumor.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1432-069X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 4 Psoriasis-Patienten, 3 davon mit zurückliegender Arsenexposition, hatten Gesamtmengen zwischen 570 und 2735 mg Methotrexat erhalten. Bei diesen Patienten wurden Chromosomendarstellungen aus dem Knochenmark und aus Lymphocytenkulturen durchgeführt. Im Knochenmark (ohne Kultur in vitro) fanden sich keine eindeutigen Aberrationen, während in den Lymphocyten in 2 Fällen gehäuft (24%) ein Chromosom regellos fehlte, und bei einem Patienten einzelne Brüche zu finden waren. Soweit aus diesen Beobachtungen in Verbindung mit den Daten der Literatur Schlüsse gezogen werden dürfen, werden sie bezüglich der Chromosomenmutationen diskutiert.
    Notes: Summary 4 patients with psoriasis, 3 of them with an history of exposure to arsenic, had received total doses of Methotrexate ranging between 570 and 2735 mg. In these patients chromosome preparations have been done from bone marrow and from lymphocyte cultures. The non-cultured bone marrow cells showed no unequivocal chromosomal alterations, but in the lymphocytes from 2 cases 1 chromosome, however not a special one, was missing in 24% of the cells. 1 case showed a few chromosomal breaks. As far as conclusions are possible from these observations they are being discussed in relation to the literature with respect to chromosomal mutations.
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  • 10
    ISSN: 1432-069X
    Keywords: Intensive cancer chemotherapy ; Spinalioma ; Mycosis fungoides ; Carcinoma of the breast ; Malignant melanoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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