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  • 1
    Call number: YY Diss Baue/Mag
    Keywords: DKFZ-publications / academic dissertations
    Pages: 82 p.
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    YY Diss Baue/Mag departmental collection or stack – please contact the library
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  • 2
    Call number: 09-MA:435/2
    Keywords: Algebras, Linear / Data processing
    Pages: viii, 439 p.
    ISBN: 3540054146
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    09-MA:435/2 departmental collection or stack – please contact the library
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  • 3
    Unknown
    Berlin : Springer
    Call number: WZ309:1/Mag
    Keywords: Aphorisms and Proverbs ; Surgery
    Pages: 178 p.
    ISBN: 3-540-05831-1
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  • 4
    Call number: ZZ1973:1a ; ZZ1973:1b/Mag ; ZZ1973:1/Mag
    Keywords: Deutsches Krebsforschungszentrum Heidelberg ; DKFZ-publications
    Pages: viii, 79 p. : ill.
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    ZZ1973:1a available
    ZZ1973:1b/Mag departmental collection or stack – please contact the library
    ZZ1973:1/Mag departmental collection or stack – please contact the library
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Archives of microbiology 94 (1973), S. 365-371 
    ISSN: 1432-072X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Incorporation of tritiated glucose into cell walls of growingSaccharomyces cerevisiac andSchizosaccharomyces pombe was studied using electron microscopic autoradiography. The pattern and the extent of labelling ofS. cerevisiae cell walls depended on the cell stage in the cell cycle. Quantitative evaluation of autoradiographs showed that the highest rate of wall synthesis took place during bud growth. The incorporation of new material into the wall of growing bud showed an increasing rate with the magnitude of the bud. The incorporation into the mother cell wall was almost negligible during bud growth. The rate of wall synthesis in double cells decreased during cell division. This period and that before new bud initiation was found to be the time of substantially reduced rate of wall replication inS. cerevisiae. A significant random incorporation was observed into the walls of post-division adult cells, both parental and daughter. The cell walls ofS. pombe were labelled almost exclusively at growing tips. The incorporation of tritiated carbohydrates into non-extensile regions ofS. pombe cell walls was found to be only about 5% of the total wall labelling.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Human genetics 〈Berlin〉 10 (1970), S. 1-7 
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The rôle of several structural and functional factors and of concentration on the cross-reactions of 28 human plasma proteins with their homologues in animal blood was investigated. The Immunological Evolution Group (IEG) system was employed for this purpose as described earlier (Bauer, 1970 a). No interaction of structural factors was detected, while an influence of serum level of the different proteins could not be ruled out with certainty. At least in the case of the 4 immunoglobulins and the 3 complement factors, included in the IEG-system, protein function and evolution show some degree of correlation, indicating the influence of function on molecular evolution in the case of these plasma proteins.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Human genetics 〈Berlin〉 10 (1970), S. 8-14 
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A correlation was found between a small range of cross-reactions of human plasma proteins among other mammalian species and levels of the respective proteins in cord blood, which are significantly lower than in adult plasma. When expressed in terms of the IEG-system (Bauer, 1970a), IEG I-proteins (cross-reacting only with homologues in pongids) showed a mean difference of 5.1 titre steps between adult and cord plasmas. For IEG IIa, IIb, IIc, and III (cross-reacting with pongid and old world monkey, new world monkey, prosimian and non-primate plasmas respectively) mean titre differences of 2.7, 1.7, 0.6 and 0.17 were found. The relative frequencies of significant differences, calculated in the Scheffé-test (a〈0.01), were 1.00 for IEG I, 0.67 for IEG IIa, 0.20 for IEG IIb and 0.00 for IEG's IIc and III. A negative feed-back mechanism regulating the rate of plasma protein mutations for plasma proteins synthesized early during fetal life is proposed and discussed in greater detail.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Human genetics 〈Berlin〉 13 (1971), S. 49-57 
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Description / Table of Contents: Zusammenfassung In Fortführung früherer Versche wurden die Kreuzreaktionen zwischen menschlichen Plasmaeiweißen und ihren Homologen im Blut von 9 Proto- und Metatheria untersucht. Monospezifische Kaninchen-Antiseren gegen 30 verschiedene menschliche Plasmaproteine wurden getestet. Dabei fand die Ouchterlony-Methode in unserer Standard-Modifikation (Bauer, 1970a) Verwendung. 4 Proteine aus dem Blut der beiden genannten primitiven Säugergruppen, nämlich Albumin, β-Lipoproteine Fibrinogen und Plasminogen, gaben Kreuzreaktionen mit ihren menschlichen Homologen. Vorläufige Ergebnisse zeigen darüber hinaus, daß die Proto- und Metatheria-Proteine weniger menschliche Determinanten tragen als irgendeines der 24 geprüften Eutheria. Die Bedeutung unserer Befunde bezüglich der molekularen Evolution der Plasmaproteine werden diskutiert.
    Notes: Summary In continuation of earlier experiments the immunological cross-reactions between human plasma proteins and homologues from 9 non-eutherian mammals were investigated, using monospecific rabbit antisera to some 30 different human plasma proteins. The Ouchterlony method in our standard modification (Bauer, 1970a) was employed. 4 proto-and metatherian proteins were found to share antigenic structures with human homologues, namely albumin, β-lipoproteins, fibrinogen and plasminogen. Preliminary experiments indicate that marsupial and monotrematal proteins have less antigenic determinants in common with man than any from the 24 non-human species, which belong to eutheria. The phylogenetical implications of our findings are discussed in some detail.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Description / Table of Contents: Zusammentassung In Fortführung früherer Versuche über eine Gruppe von 20 menschlichen Plasmaproteinen wurden die immunologischen Kreuzreaktionen zwischen menschlichem und tierischem β 2-Glycoprotein II, β 2-Glycoprotein III, IgD und Inter-α-Trypsininhibitor untersucht. Damit wurde versucht, Informationen über die Evolution dieser Eiweiße zu gewinnen, von denen bisher erst wenige chemische Daten vorliegen. Die menschlichen β 2-Glycoprotein II und III zeigen Kreuzreaktionen mit ihren Homologen in den Seren von Gorilla gorilla, Pongo pygmaeus und Macaca nemestrina (Gruppe II unserer Nomenklatur), der Inter-α-Trypsininhibitor des Menschen mit denjenigen von Gorilla gorilla und Pongo pygmaeus und IgD (δ-Kette) nur mit denjenigen von Gorillaserum (Gruppe I). Mit den Seren von Papio anubis, Cebus albifrons und Galago crassicaudatus sowie von einigen Mammalia außerhalb der Primaten wurden keine Kreuzreaktionen gefunden. Bei allen vier Eiweißen war durch vergleichende Analyse kein Nachweis einer antigenen Heterogenität möglich. Die Ergebnisse werden kurz im Zusammenhang mit Befunden bei anderen Plasmaproteinen diskutiert.
    Notes: Summary In continuation of earlier experiments on a group of 20 human plasma proteins the immunological cross-reactions between human and animal β 2-glycoprotein II, β 2 III, IgD and inter-α-trypsininhibitor have been investigated in an attempt to elucidate the evolution of these proteins, for which only few chemical data are available. Human β 2-glycoproteins II and III cross-react with their counterparts in the sera of gorilla gorilla, pongo pygmaeus, macaca nemestrina (group II of our nomenclature), human inter-α-trypsininhibitor with gorilla gorilla, pongo pygmaeus and IgD (δ-chain) only with gorilla gorilla sera (group I). No reaction was observed with sera of papio anubis, cebus albifrons and galago crassicaudatus as well as with sera of several non-primate mammals. No antigenic heterogeneity was demonstrable by comparative analysis in any of these 4 proteins. The results are discussed briefly in comparison with findings reported on other plasma proteins.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Human genetics 〈Berlin〉 8 (1970), S. 325-329 
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Description / Table of Contents: Zusammenfassung Die Kreuzreaktionen zwischen menschlichen Plasmaeiweißen und ihren Homologen im Blut von subhumanen Primaten wurden systematisch untersucht. Von den drei früher voneinander abgetrennten Gruppen [2] wurden zwei für die vorliegende Versuchsreihe herausgegriffen; eine von ihnen konnte weiter unterteilt werden. Die erhobenen Befunde werden berichtet und diskutiert. Die Immunologische Evolutions-Gruppe (IEG) I, die IgA (α-Kette), IgD (δ-Kette) und den Inter-α-Trypsininhibitor umfaßt, zeight Kreuzreaktionen nur mit den Plasmen von Pongiden. Die IEG IIa, zu der IgM (μ-Kette), die β 2 II und III und Cholinesterase gehören, kreuzreagiert mit den entsprechenden Plasmaproteinen der geprüften Pongiden und Cercopithecoidea, die IEG IIb—das sind saueres αl-Glycoprotein, α2HS-Glycoprotein, αl-Trypsininhibitor, Haptoglobin und Haemopexin — mit Pongiden, Cercopithecoidea und Cebus (Platyrrhini) und endlich die IEG IIc, die sich aus Transferrin und dem Gc-Globulin zusammensetzt, mit allen geprüften Primatenplasmen einschließlich denen von Prosimiern. Alle hier genannten Plasmaeiweiße zeigen jedoch keine Kreuzreaktionen mit Proteinen von Nichtprimaten, wie dies bei der IEG III der Fall ist. Aus den vorliegenden Befunden wird der Schluß gezogen, daß die Determinanten der Primatenproteine, die jeweils reagieren, in ihrem phylogenetischen Alter von IEG Iüber IEG IIa, IIb, IIc im gleichen Maße ansteigen, wie die letzten gemeinsamen Vorfahren von Mensch und den kreuzreagierenden Arten.
    Notes: Summary Cross-reactions between human plasma proteins and their homologues in primate blood were investigated systematically. From the three groups of proteins distinguished earlier [2] two have been especially examined; these findings are reported and discussed in the present communication. The Immunological Evolution Group (IEG) I, comprising IgA (α-chain), IgD (δ-chain) and inter-α-trypsininhibitor, cross-reacts with pongid plasma only, IEG IIa, i.e. IgM (μ-chain), β 2-glycoproteins II and III and cholinesterase, does so with the pongid and cercopithecoid plasmas tested; IEG IIb, including acid αl-glycoprotein, α2HS-glycoprotein, αl-trypsininhibitor, haptoglobin and hemopexin, cross-reacts with pongid, cercopithecoid and cebus (platyrrhinian) plasma and finally IEG IIc, consisting of transferrin and Gc-globulin, does so with all primate plasmas tested, including prosimians. All the proteins named do not cross-react however with non-primate proteins as do those of IEG III. It is concluded, that the determinants reacting in the primate proteins increase in their evolutionary ages from IEG I over IEG IIa, IIb to IIc in the same way as the last common ancestors of man and the crossreacting species increase.
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