Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    ISSN: 1433-8580
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 2
    ISSN: 1433-8580
    Keywords: Renal preservation ; Anaerobic ischemia ; Aerobic ischemia ; Retrograde renal O2 persufflation ; Post-ischemic renal function
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Retrograde persufflation of ischemic kidneys of dogs via the renal vein with gaseous O2 was evaluated as a method of kidney preservation (retrograde aerobic ischemia) and compared to conventional ischemic storage without additional measures (anaerobic ischemia). Renal preservationin situ lasted 4 hrs at 6°C. A contralateral nephrectomy was performed before the preservation period. For retrograde aerobic ischemia the persufflation pressure was 30 mm Hg, the gas flowed off via opened capsular vessels. While dogs which had undergone renal anaerobic ischemia showed a marked temporary post-ischemic increase in renal blood flow and in the systemic blood pressure, dogs submitted to renal retrograde aerobic ischemia did not exhibit a storage induced loss of the renal vascular autoregulation. During and after retrograde aerobic ischemia the renal tissue levels of ATP, ADP, and AMP remained within normal ranges; ATP and the sum of adenine nucleotides decreased markedly during anaerobic ischemia. In both the groups a normal renal function was resumed again; but the recovery time of various parameters of renal function (clearance from inulin and PAH, urea excretion, serum concentrations of urea and creatinine) was shorter after retrograde aerobic ischemia than after anaerobic ischemia. Kidneys subjected to retrograde aerobic ischemia exhibited a better functional adaption to the contralateral nephrectomy during the 3 weeks of post-ischemic observation than kidneys stored in anaerobic ischemia.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 3
    ISSN: 1432-0428
    Keywords: Human adipose tissue ; fat cell size ; obesity ; lipolysis ; reesterincation ; norepinephrine ; theophylline ; DB-C-AMP
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Le but de ce travail est d'examiner si la lipolyse (libération de glycérol et d'acides gras libres) du tissu adipeux humain sous-cutané étudiéin vitro est affectée par l'excès ou le déficit pondéral et par la taille des adipocytes. Chez 86 sujets, une relation très étroite a pu être établie entre l'excès ou le déficit pondéral d'une part, et le logarithme de la teneur en lipides ou le logarithme du diamètre moyen des adipocytes du tissu adipeux sous cutané abdominal d'autre part. Cependant, même en cas d'adiposité extrême le diamètre moyen de l'adipocyte ne dépasse pas 135μ. Dans ces cas, l'obésité dépend à la fois d'une hypertrophie et d'une hyperplasie du tissu adipeux. La libération basale d'acides gras et de glycérol dans le milieu d'incubation n'est pas affectée par la surcharge pondérale, si l'on se réfère à la teneur en lipides du tissu adipeux. Par contre, cette libération d'acides gras et de glycérol est significativement plus grande si l'on se réfère au diamètre moyen des cellules. Dans l'obésité, la libération d'acides gras libres est proportionellement plus faible que celle de glycérol. Une augmentation de la lipolyse a pu être obtenue par l'adjonction au milieu d'incubation de nor-adrénaline, de théophylline et de dibutyryl-AMP cyclique. La relation dose-effet fut comparable que le tissu adipeux provienne de sujets de poids normal ou d' individus obèses. Néanmoins, exprimée en % des valeurs de base, la stimulation de la lipolyse est plus faible chez les patients obèses. Une corrélation négative entre la réponse lipolytique au dibutyryl-AMP cyclique et le diamètre des adipocytes a été observée. La quantité absolue de glycérol ou d'acides gras libérés en présence de noradrénaline, de théophylline ou de dibutyryl-AMP cyclique était en corrélation positive avec le diamètre des adipocytes. Bien que le glucose stimule la libération de glycérol et inhibe la libération d'acides gras libres, ces effets du glucose n'ont pu être mis en relation avec le diamètre cellulaire moyen. — Nos observations nous permettent de conclure que les adipocytes de grande taille possèdent une quantité supplémentaire de lipase et que dans les conditions basales la proportion de lipase active dans ces cellules est vraisemblablement plus élevée.
    Abstract: Zusammenfassung Die Lipolyse (Freisetzung von Glycerin und freien Fettsäuren) des subcutanen menschlichen Fettgewebesin vitro wurde in Abhängigkeit vom relativen Körpergewicht und der Fettzellgröße untersucht. Bei 86 Personen bestanden hochsigniflkante logarithmische Beziehungen zwischen relativem Körpergewicht, Fettzelldurchmesser und Lipidgehalt des subcutanen Fettgewebes der Bauchregion. Ein mittlerer Fettzelldurchmesser von 135 μ wurde auch bei extremer Adipositas praktisch nie überschritten. Adipositas ist in diesen Fällen auf Hypertrophie und Hyperplasie des Fettgewebes zurückzuführen. — Die basale Freisetzung von Glycerin und freien Fettsäuren bezogen auf den Lipid-gehalt war bei Normund Übergewicht nicht signifikant unterschieden. Die Metabolitfreisetzung der Einzelzelle nahm jedoch mit wachsendem Zelldurchmesser zu. Der LipolysequotientQ (Verhältnis FFS-Freisetzung: Glycerinfreisetzung) war bei Adipositas signifikant kleiner. — Die Lipolyse wurde durch Norepinephrin, Theophyllin und Dibutyryl-cyclo-AMP stimuliert. Die Konzentrations-abhängigkeit der Effekte war bei Normund Übergewicht ähnlich. — Die Stimulierbarkeit der Lipolyse in Prozent des Basalwertes war bei Adipositas vermindert. Es bestand eine negative Korrelation der Stimulierbarkeit durch Dibutyryl-cyclo-AMP zum Zelldurchmesser. Die absolute Metabolitfreisetzung der Fettzelle bei Stimulation mit Noradrenalin, Theophyllin oder Dibutyryl-cyclo-AMP nahm mit steigender Zellgröße signifikant zu. — Zusatz von Glucose führte zur Steigerung der Glycerin-freisetzung und zur Hemmung der FFS-Freisetzung, die Korrelation der Lipolyse zum Zelldurchmesser wurde dadurch nicht wesentlich verändert. — Diese Beobachtungen lassen den Schluß zu, daß große Zellen mit zusätzlicher Gesamtlipase ausgestattet sind und daß unter Basalbedingungen das Verhältnis inaktiver Prolipase zur aktiven Lipase zugunsten des aktiven Enzyms verschoben ist.
    Notes: Summary Lipolysis (release of glycerol and free fatty acids) of subcutaneous human adipose tissuein vitro has been investigated in relation to relative body weight and fat cell size. Studying 86 persons, there was a highly significant logarithmic relation between relative body weight, fat cell size and lipid content of subcutaneous adipose tissue obtained from the abdominal region. Even in extreme obesity a mean fat cell diameter of 135 μ was generally not exceeded. In these cases overweight is due to hypertrophy as well as hyperplasia of adipose tissue. — The basal FFA and glycerol release, calculated on the basis of the lipid content, did not significantly differ in normal and overweight persons. The lipolysis of the individual cell increased, however, with increasing cell diameter. The quotient of resterification (FFA release: glycerol release) was significantly lower in obesity. — When lipolysis was stimulated with norepinephrine, theophylline or dibutyryl-cyclic AMP, the dose response relations were similar in obesity and normal weight. — The stimulation of lipolysis, expressed as % of baseline, was diminished in obesity. Stimulation with dibutyryl-cyclic-AMP was negatively correlated to the cell diameter. — The absolute release of metabolites per fat cell after stimulation with norepinephrine, theophylline or dibutyryl-cyclic AMP was positively correlated with the fat cell diameter. — Addition of glucose resulted in an increment in glycerol release and an inhibition of FFA release. However, the correlation of lipolysis with fat cell diameter was not affected. — The observations suggest that large fat cells are provided with additional total lipase. Under basal conditions the relation of inactive pro lipase to active lipase seemed to change in favour of the active enzyme.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 4
    ISSN: 1432-0711
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Archives of dermatological research 246 (1973), S. 167-174 
    ISSN: 1432-069X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Nach intradermaler Applikation von Arginin-C-14 an Meerschweinchen bzw. von Ornithin-C-14 an haarlosen Mäusen wurde jeweils ein Radiometabolit in den Hydrolysaten großmolekularer Epidermis-(Protein-)Fraktionen gefunden, der sich bei Säulenchromatographie an Dowex 50 wie Citrullin verhielt. In der kleinmolekularen Fraktion der Epidermis („Wasserlösliches“ WI) lagen als Radiometaboliten offenbar Citrullin und Harnstoff vor.
    Notes: Summary After intracutaneous injection of arginine-C-14 into guinea pigs or of ornithine-C-14 into hairless mice, respectively, a radiometabolite could be found in hydrolyzed, macromolecular epidermis fractions, which by column chromatography on Dowex 50 showed the same behavior as citrulline. In the ultrafiltrable fraction of the epidermis (“the water-soluble substances”), the detected radiometabolites seemed to be citrulline and urea.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 6
    ISSN: 1432-0711
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 7
    ISSN: 1433-8580
    Keywords: Renal preservation ; Anaerobic ischemia ; Aerobic ischemia ; Renal O2-persufflation ; Post-ischemic renal function
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In search for new techniques of renal preservation, kidneys were persufflatedin situ with gaseous O2 at a pressure of 90–100 mm Hg via their vascular system (orthograde aerobic ischemia). The results on post-ischemic function and blood flow, and on the changes in the renal tissue levels of the adenine nucleotides were compared to those obtained from kidneys ischemically stored without additional measures (anaerobic ischemia). The kidneys were stored for 4 hrs at 6°C. A contralateral nephrectomy was performed before the preservation period. All dogs subjected to renal anaerobic ischemia survived. After orthograde aerobic ischemia, 3 out of 4 dogs died from uremia within 8 days, 1 animal survived. Although the aerobic ischemic preservation resulted in the maintenance of a metabolic status characteristic for aerobiosis, post-ischemic renal function recovered too slowly and insufficiently on the average. Renal blood flow was within normal ranges after anaerobic ischemia, it was reduced to about one third of this after orthograde aerobic ischemia.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 8
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 95 (1973), S. 7923-7923 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 9
    ISSN: 1432-1351
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Investigations in 10 species showed that respiration of birds in flight is usually co-ordinated with wing beats, but the co-ordination is not obligatory. Respiration synchronous with wing beats (1∶1 co-ordination) was found only in pigeons and crows, the other species exhibited one of 11 other types of co-ordination. Quails, ducks and pheasants, birds with relatively high wing beat frequencies (with relatively small wings) showed a 5∶1 co-ordination. Within species, and even during a flight the type of co-ordination changed, and simultaneously there were sudden changes in the respiration frequency. For the most part, the beginning of inspiration was linked with the (end of) upstroke and the beginning of expiration with the end of downstroke.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 10
    ISSN: 1432-1351
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Pulmonary ventilation (tidal volume, frequency) and oxygen content of expired air were measured in separate flights for 3 species of birds — Evening Grosbeak (Hesperiphona vespertina), Ring-billed Gull (Larus delawarensis), and Black Duck (Anas rubripes). Heart rate was measured in flight or immediately after landing in 12 species. Respiratory frequency and tidal volume were greater in flight than during rest. As the O2 content of expired air did not change appreciably, the increase in O2 consumption was similar to the increase in ventilation and averaged more than 10 times basal. The influence of body weight on metabolism during flight was similar to that previously observed under basal conditions. Heart rates during flight (10 species), immediately after landing (12 species), and maximal rates from various authors (15 species) were in close agreement, and were 2–4 times as high as during rest. The heart rate decreased with increasing body weight according to the equation HRf=25.1 BW−0.16 (HR per sec, BW in g). In flight there was much less variation and there was a smaller decrease with increasing weight than during rest. Although the estimated stroke volume and heart size appear larger in birds, the ratio of these functions was similar to that in mammals.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...