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  • 1
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Notes: Summary Goldfish were fed DDT for three weeks, then exposed to phenobarbital solution for one week to study the possibility of microsomal enzyme induction and therefore possibly enhanced insecticide excretion. Analysis of DDT, DDE and DDD were made at intervals up to six weeks. Forty percent of the DDT fed was incorporated during the feeding. It was recovered mainly as DDE (68 to 96%). Significant differences between pesticide levels of phenobarbital treated and control fish were not found.
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  • 4
    ISSN: 1432-1246
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In Tierversuch und Klinik wurde der Einflu\ der Stickstoffoxyde auf die Immunität untersucht. Bei Meerschweinchen beobachtete man nach 6 Monate langer Exponierung auf l ppm Stickstoffoxyde eine Immunitätsschwächung mit vermehrten Infektionen, vor allem der Atmungsorgane. Immunologische Untersuchungen zeigten eine Schwächung der Hämolyseaktivität des Komplements, während die Immunoelektrophorese eine Verminderung sämtlicher Fraktionen ergab. Bei mit Diplococcus pneumoniae intranasal infizierten Mäusen wies die stickstoffoxydbeatmete Gruppe eine erhöhte Sterblichkeit auf. Auf Grund der immunologischen Untersuchungen wurde als Ursache des Immunitätsrückgangs Störung der Eiwei\synthese erkannt, was eine auffällige Hemmung der Körpergewichtszunahme bei den chronisch vergifteten Meerschweinchen bestätigt. Die klinischen Untersuchungen an beruflich Stickstoffoxyd-Gefährdeten ergaben allgemein eine Senkung des Eiwei\spiegels, Verminderung der Albumine und IgG-Globuline sowie Vermehrung der Immunoglobuline IgA und IgM. Letztere Beobachtung dürfte auf einen den IgG-Mangel kompensierenden Mechanismus oder aber auf öftere bakterielle Erkrankungen der Atmungsorgane bei Stickstoff-Gefährdung hinweisen. Die verringerten IgG-Globulin-Werte dürften auf stickstoffoxydbedingte Synthesestörungen zurückzuführen sein und könnten Ursache einer verminderten Infektionsimmunität bei den Gefährdeten sein.
    Notes: Summary The effect of nitrogen oxides on immunity was examined in animal experimentation and in clinical trials. In guinea pig, immunity was found to be lowered following 6 months' exposure to 1 ppm; there was an increased incidence of injection, the respiratory organs being particularly frequently affected. Immunological examination revealed reduced hemolytic activity of the complement, while immunoelectrophoresis showed a reduction in all fractions. When mice were infected intranasally with Diplococcus pneumoniae the group exposed to inhalation of nitrogen oxides showed a higher mortality than the control group. The immunological examination revealed that the lowered immunity was due to impaired protein synthesis, which was confirmed by a striking inhibition of weight gain in guinea pigs suffering from chronic intoxication. Clinical examination of patients who had suffered harmful occupational exposure to nitrogen oxides revealed a depressed protein level, reduced levels of albumin and IgG globulins and raised levels of IgA and IgM immunoglobulins in most cases. This last observation may be indicative of a compensatory mechanism precipitated by the IgG deficiency, but could also indicate frequent bacterial infections of the respiratory organs following exposure to nitrogen oxide. The reduced levels of IgG globulin may be attributable to impaired synthesis caused by nitrogen oxides and could be the reason for the lower immunity to infection in the patients affected.
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  • 5
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In an attempt to transmit feline malignant lymphoma to mice, a murine hepatitis virus (MHV) was accidentally recovered from conventionally reared Swiss mice receiving prolonged treatment with antilymphocyte serum. In these mice, the virus did not require concomitant infection withEperythrozoon coccoides to produce disease. Tests for antibodies against a variety of viruses were performed on serum from control colony mice and mice that recovered from experimental infection as well as on serum pooled from vaccinated and non-vaccinated mice challenged with the recovered agent. Antibodies to the MHV complement fixing (CF) antigen(s) were demonstrated in only the last mentioned serum. Mice harbouring a hepatitis virus may thus be tolerant to their CF antigen(s) in a situation analogous to oncornavirus infection of their natural hosts. The liver pathology was that of a confluent focal-type necrosis resembling that produced by certain other MHV strains. We have labelled this newly isolated virus MHV (Swiss-Cape Town), abbreviated to MHV (S-CT).
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Virchows Archiv 352 (1971), S. 182-194 
    ISSN: 1432-2307
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Anhand von 14 eigenen Fällen wird das Krankheitsbild der atypischen bakteriellen Endokarditis mit Klappenringabsceß beschrieben. Das Krankheitsbild kommt in höherem Alter vor, es besteht ein starkes Überwiegen des weiblichen Geschlechts. Größere Absceßbildungen im verkalkten Faserring der Mitralklappe, konstante Endokarditis im subvalvulären Winkel und inkonstante thrombulceröse Endokarditis an der Klappenoberfläche kennzeichnen das anatomische Bild bei den 12 akuten Fällen. Bei 2 chronischen Fällen mit abgekapseltem Klappenringabsceß fehlt die Endokarditis. Die Klappenringabscesse und die sie begleitende basale „atypische“ Endokarditis sind regelmäßig im marginalen Segel der Mitralklappe lokalisiert. Wichtige pathogenetische Faktoren sind die senile Klappenringsklerose mit Bewegungseinschränkung des marginalen Segels, Stase im subvalvulären Winkel und verkalkende höckerige Thrombenabscheidungen subvalvulär mit Nischenbildungen, in denen die Bakterienansiedelung auf frischen Thromben erfolgt. Von der akuten subvalvulären Endokarditis geht die Infektion des Faserringes und die Absceßbildung aus. Sie kann — in dieser Untersuchungsreihe in der Hälfte der Fälle — auch zu thrombulceröser Endokarditis an der atrialen Seite der Mitralklappe führen. In 5 von 10 bakteriologisch untersuchten Fällen wurde Staphylococcus aureus, in 2 Fällen Streptococcus pyogenes, in 2 weiteren Fällen Escherichia coli und bei einem Fall Salmonella cholerae suis als Erreger nachgewiesen. Die unicale Beobachtung eines Klappenringabscesses durch S. cholerae suis wird ausführlicher besprochen.
    Notes: Summary Fourteen cases of valve ring abscesses of the heart associated with atypical bacterial endocarditis are presented. This entity occurs in the older age groups and predominately in women. Large abscesses in the calcific mitral annulus, constant endocarditis in the subvalve angle, and inconstant thrombo-ulcerous endocarditis on the atrial surface characterize the pathoanatomical pattern in our twelve acute cases. Endocarditic lesions could not be found in two chronic cases with encapsulated valve-ring abcesses. Usually, the valve ring abscesses and the concomitant basic atypical endocarditis are localized on the posterior mitral cusp. Important pathogenetic factors are senile mitral annulus sclerosis, a decreased movement of the posterior cusp, stasis in the subvalve angle, and calcifying humpy subvalvular thrombotic deposits that form pockets for fresh thrombi which become invaded by bacteria. The infection of the valve rings and the following ring abscesses originate from the acute subvalvular endocarditis. However, this mode of infection can cause the inconstant thromboulcerous endocarditis on the atrial surface, which developed in only the half of our cases. In five of ten cases examined bacteriologically Staphylococcus aureus was grown, in two other cases Streptococcus pyogenes, in two cases Escherichia coli, and in one instance Salmonella cholerae suis. To our knowledge, this is the first case reported of a valve ring abscess due to S. cholerae suis. It has been particularly discussed.
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  • 7
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
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  • 8
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary A spontaneous leukemia in mice of the C57Bl6 strain was treated with antilymphocyteserum (ALS) alone and in combination with cyclosphosphamide. The WBC was lowered and survival times were prolonged by antilymphocyteerum treatment alone. Antilymphocyteserum combined with cyclophosphamide doubled the survival time. The effect of antilymphozyteserum and cyclophosphamide was better than the addition of the single effects.
    Notes: Zusammenfassung Eine spontane Leukämie in C57Bl6-Mäusen wurde mit Antilymphozytenserum (ALS) allein und in Kombination mit Cyclophosphamid behandelt. Antilymphozytenserum allein bewirkte eine Erniedrigung der peripheren Leukozytenzahl und verlängerte die Überlebenszeit der Tiere. Durch die Kombination Antilymphozytenserum-Endoxan ließ sich die Überlebenszeit der Tiere auf das Doppelte verlängern. Die Ergebnisse der Versuche sprechen für eine Potenzierung der Wirkungen beider Mittel.
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  • 9
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Annals of hematology 22 (1971), S. 218-220 
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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