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  • 1970-1974  (7)
  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 86 (1972), S. 0 
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary.— Three case of unilateral idiopathic hyperhidrosis are described. Two of the lesions were congenital; the thrid occurred in later life. Quantitative sweat collections demonstrated that the sweat glands in the lesion were hyperresponsive to those stimuli, which normally evoked sweating in the skin sites where the lesions occurred. Hyper-responsiveness of the sweat glands to cholinergic stimuli was also demonstrated, and histology revealed greatly enalrged glands.These results suggest that the hyperhidrosis is due to Increased glandular mass, although sweat gland hypersensitivity could notberuled out as an additional contributing factor to the hyperhidrosis.Local anticholinergic therapy was found to besuccessful in the treatment of all 3 patients.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1612-1112
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary Thin layer chromatography on silica gel was used to separate and semiquantitate d-chondrocurarine chloride in d-tubocurarine chloride at the 0.5% to 2% level. This system was also found to separate the o-methylated chondrocurarine iodide and other compounds related to d-tubocurarine chloride.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1617-4623
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Log phase cells of Saccharomyces cerevisiae, fully density labelled by growth in 15N medium, were transferred to medium containing only 14N, and DNA replication followed by isopycnic banding in CsCl. Nuclear DNA replicated semi-conservatively, but mitochondrial DNA showed a dispersive pattern, appearing throughout as a single unimodal gradient band the density of which decreased continuously throughout the period of growth. Approaching its first doubling, the mitochondrial component developed marked density heterogeneity, but this was largely dissipated by the time the second doubling was reached. Analysis of single strand densities showed that this phenomenon was an early consequence of a process in which previously incorporated 15N atoms were continually redistributed between old and new DNA strands. By two doublings the operation of this process resulted in the single strands of mitochondrial DNA being indistinguishable in terms of density. The kinetics of density loss of the mitochondrial component showed that incorporation of 15N into mitochondrial DNA following the transfer was negligible and that essentially all pre-incorporated 15N was conserved, indicating the probable absence of metabolic turnover. It was concluded that a primary semi-conservative strand copying step in the replication of mitochondrial DNA is accompanied or closely followed by extensive partial exchanges of homologous strands between duplexes.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1617-4623
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Low concentrations of erythromycin and chloramphenicol (≤0.3 mg/ml) specifically affect intra-mitochondrial protein synthesis in most strains of Saccharomyces cerevisiae, thereby preventing growth on non-fermentable substrates. This effect is reversible, the genetic capacity for respiration in the absence of the drug being unaffected. However, we now show that exposure of growing cells to high concentrations (1.3–3.0 mg/ml) of either antibiotic generates a high frequency of cytoplasmic petite (respiratory-deficient) mutants with a concomitant loss of the cytoplasmic genetic determinant for respiration known as the rho factor. In one strain in which the effect of erythromycin was examined, the entire population abruptly underwent mutation but only after exposure to the drug for several generations. Mitochondrial DNA was synthesised normally during the silent pre-mutational period, but was rapidly lost, by a process partly dependent on degradation, at the time of the mutational event. Intra-mitochondrial protein synthesis was inhibited only about 67% by the lower levels of erythromycin but was completely (99%) inhibited by the higher petite-inducing levels. These results are interpreted as evidence that the normal maintenance of mitochondrial DNA in this organism requires a protein(s) whose assembly in the mitochondria is completely blocked only by high erythromycin concentrations. This protein is normally present in excess and on exposure to high drug levels replication of mitochondrial DNA is unaffected until the supply runs out. When this happens, replication ceases, existing molecules are degraded, and rho factors are destroyed.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Helgoland marine research 20 (1970), S. 417-434 
    ISSN: 1438-3888
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Description / Table of Contents: Summary 1. The main methods which have been used for obtaining and rearing decapod larvae are reviewed. These methods range from very simple ones involving little or no control over the environmental conditions, to quite complex techniques with control over such factors as temperature, salinity, and light. 2. The difficulties encountered in rearing decapod larvae are largely the same as those met with in rearing any other planktonic organisms. Although failure to provide suitable food is probably the most important single factor responsible for the failure of many attempts in the past, other features of the rearing conditions may also be critical. In this context the effects of temperature, salinity, light and water type on larval development are briefly discussed. 3. No single rearing technique is suitable for all species and all situations. The choice of technique in any particular case will, therefore, depend largely on the aim in view, whether it be taxonomic, physiological, behavioural or commercial.
    Notes: Kurzfassung Es werden Methoden zur Gewinnung und Zucht von Larven decapoder Crustaceen beschrieben. Die mit Erfolg eingesetzten Zuchteinrichtungen reichen von einfachen Glasschalen bis zu Geräten mit Wasserzirkulation, Belüftung, Ultraviolettbestrahlung und Temperaturkontrolle. Wert und Verfügbarkeit verschiedener Nahrungsobjekte sowie die Bedeutung von Temperatur, Salzgehalt, Licht und Wasserqualität werden erörtert. Methoden für die Massenzucht decapoder Crustacea werden kurz beschrieben und allgemeine Richtlinien in bezug auf die Wahl der Kultivierungsmethode und die Zielsetzung der Untersuchungen diskutiert.
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