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  • 1
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Eine Methode zur kathodenstrahlpolarographischen Bestimmung kleiner Mengen α,β-ungesättigter Ketone in MIBK wird beschrieben. Die statistische Nachweisgrenze beträgt 8,6 · 10−5% (das entspricht 0,9 ppm), berechnet als Mesityloxid. Die gas-chromatographisch vom MIBK getrennten ungesättigten Ketone werden durch IR- und KMR-spektroskopische Untersuchungen charakterisiert.
    Notes: Summary A method is described for determining small amounts of α,β-unsaturated ketones in methylisobutyl ketone by cathode-ray polarography. Traces are detectable down to 1 ppm. The unsaturated ketones are separated from methylisobutyl ketone by gas chromatography and are characterized by IR and NMR spectroscopy.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Die kathodenstrahlpolarographische Bestimmung von Ni, Pb, Cu, Co, Fe, Mo, Te, Sn, Zn, Bi, Cd, Tl in Tetrachlorogoldsäure wird beschrieben. Die Nachweisgrenzen liegen im 10−4%- bzw. 10−5%-Bereich (Ni, Co, Mo). Die Spuren werden über einen Ionenaustauscher AG 1X8 untereinander und von der Matrix getrennt.
    Notes: Abstract A method is described for the cathode-ray polarographic determination of traces of Ni, Pb, Cu, Co, Fe, Mo, Te, Sn, Zn, Bi, Cd, Tl in H(AuCl4). Gold is separated from the trace metals by absorption on the strongly basic anion-exchange resin AG 1X8. The detection limits are within the ranges of 10−4% and 10−5% ((Ni, Co, Mo).
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Eine Methode wird beschrieben, die die kathodenstrahlpolarographische Bestimmung von Spuren Ni, Pb, Mn, Co, Cu, Fe, Mo in Zinnchloriden in den Bereichen 10−4% (Ni, Pb, Mn, Cu, Fe) und 10−5% (Mo, Co) gestattet. Über den stark basischen Anionenaustauscher AG 1×8 wird das Zinn von den Spurenelementen getrennt.
    Notes: Abstract A method is described for the cathode-ray polarographic detemination of traces of Ni, Pb, Mn, Co, Cu, Fe, and Mo in tin chlorides. Tin is separated from the trace metals by ion exchange on the strong basic anion-exchange resin AG 1×8. The detection limits are within the ranges of 10−4% and 10−5%.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Eine Methode zur kathodenstrahlpolarographischen Bestimmung von Spuren Kobalt und Zink in Nickel und Nickelsalzen wird beschrieben. Die Spuren werden untereinander und von der Matrix über den Anionenaustauscher Dowex 1X8 getrennt. Die Nachweisgrenzen betragen für Kobalt 5·10−4% und für Zink 4·10−4%.
    Notes: Summary A method is described for the cathode-ray polarographic determination of cobalt and zinc traces in nickel and nickel salts after separation by the anionexchange resin Dowex 1X8. Traces are detectable as low as 5·10−4% and 4·10−4%, respectively.
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  • 5
    Publication Date: 2018-12-04
    Description: T cells are highly conserved in jawed vertebrates, suggesting an essential role in the immune system. However, T cell–deficient Tcrd –/– mice display surprisingly mild phenotypes. We hypothesized that the lack of T cells in constitutive Tcrd –/– mice is functionally compensated by other lymphocytes taking over genuine T cell functions. To test this, we generated a knock-in model for diphtheria toxin–mediated conditional T cell depletion. In contrast to IFN-–producing T cells, IL-17–producing T cells (T17 cells) recovered inefficiently after depletion, and their niches were filled by expanding Th17 cells and ILC3s. Complementary genetic fate mapping further demonstrated that T17 cells are long-lived and persisting lymphocytes. Investigating the function of T cells, conditional depletion but not constitutive deficiency protected from imiquimod-induced psoriasis. Together, we clarify that fetal thymus-derived T17 cells are nonredundant local effector cells in IL-17–driven skin pathology.
    Print ISSN: 0022-1007
    Electronic ISSN: 1540-9538
    Topics: Medicine
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  • 6
    Publication Date: 2018-05-25
    Description: Computations in the mammalian cortex are carried out by glutamatergic and -aminobutyric acid–releasing (GABAergic) neurons forming specialized circuits and areas. Here we asked how these neurons and areas evolved in amniotes. We built a gene expression atlas of the pallium of two reptilian species using large-scale single-cell messenger RNA sequencing. The transcriptomic signature of glutamatergic neurons in reptilian cortex suggests that mammalian neocortical layers are made of new cell types generated by diversification of ancestral gene-regulatory programs. By contrast, the diversity of reptilian cortical GABAergic neurons indicates that the interneuron classes known in mammals already existed in the common ancestor of all amniotes.
    Keywords: Evolution, Molecular Biology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
    Publication Date: 2015-02-28
    Description: Evolutionary expansion of the human neocortex reflects increased amplification of basal progenitors in the subventricular zone, producing more neurons during fetal corticogenesis. In this work, we analyze the transcriptomes of distinct progenitor subpopulations isolated by a cell polarity-based approach from developing mouse and human neocortex. We identify 56 genes preferentially expressed in human apical and basal radial glia that lack mouse orthologs. Among these, ARHGAP11B has the highest degree of radial glia-specific expression. ARHGAP11B arose from partial duplication of ARHGAP11A (which encodes a Rho guanosine triphosphatase-activating protein) on the human lineage after separation from the chimpanzee lineage. Expression of ARHGAP11B in embryonic mouse neocortex promotes basal progenitor generation and self-renewal and can increase cortical plate area and induce gyrification. Hence, ARHGAP11B may have contributed to evolutionary expansion of human neocortex.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Florio, Marta -- Albert, Mareike -- Taverna, Elena -- Namba, Takashi -- Brandl, Holger -- Lewitus, Eric -- Haffner, Christiane -- Sykes, Alex -- Wong, Fong Kuan -- Peters, Jula -- Guhr, Elaine -- Klemroth, Sylvia -- Prufer, Kay -- Kelso, Janet -- Naumann, Ronald -- Nusslein, Ina -- Dahl, Andreas -- Lachmann, Robert -- Paabo, Svante -- Huttner, Wieland B -- New York, N.Y. -- Science. 2015 Mar 27;347(6229):1465-70. doi: 10.1126/science.aaa1975. Epub 2015 Feb 26.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG), Pfotenhauerstrasse 108, D-01307 Dresden, Germany. ; Technische Universitat Dresden, Center for Regenerative Therapies Dresden, Fetscherstrasse 105, D-01307 Dresden, Germany. ; Max Planck Institute for Evolutionary Anthropology (MPI-EVA), Deutscher Platz 6, D-04103 Leipzig, Germany. ; Technische Universitat Dresden, Universitatsklinikum Carl Gustav Carus, Klinik und Poliklinik fur Frauenheilkunde und Geburtshilfe, Fetscherstrasse 74, D-01307 Dresden, Germany. ; Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG), Pfotenhauerstrasse 108, D-01307 Dresden, Germany. huttner@mpi-cbg.de.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25721503" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Separation ; GTPase-Activating Proteins/chemistry/genetics/*physiology ; Gene Duplication ; *Gene Expression Regulation, Developmental ; Humans ; Lateral Ventricles/cytology ; Mice ; Neocortex/cytology/*embryology/metabolism ; Neural Stem Cells/*cytology/metabolism ; Neurogenesis/*genetics ; Neuroglia/cytology/metabolism ; Neurons/cytology/metabolism ; Protein Structure, Tertiary ; Transcriptome
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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