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  • 2000-2004  (1)
  • 1965-1969  (1)
  • 1960-1964  (1)
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  • 1
    ISSN: 1591-9528
    Keywords: Shock ; Blood Cytology ; Circulatory failure ; Shock, experimental ; Bone marrow, Cytology ; Schock ; experimenteller Schock ; Blut-Cytologie ; Knochenmarks-Cytologie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 1. In Untersuchungen an Leukocytenkonzentraten des peripheren Blutes von 40 Patienten mit klinisch gesichertem Schock und von 20 Kontrollpersonen ohne Schockzeichen konnte gezeigt werden, daß Plasmoblasten, Proplasmazellen, Plasmazellen, Promyelocyten, Myelocyten und Erythroblasten bei den Schockpatienten statistisch signifikant häufiger vorkamen als in der Kontrollgruppe. 2. Weiterhin wurden Zellkonzentrate aus dem Blut und aus den Nierenperfusaten von 15 Kaninchen mit experimentellem Entblutungsschock und von 10 Kontrolltieren cytologisch untersucht. Folgende Zellformen wurden in der Schockgruppe statistisch signifikant häufiger angetroffen: in den Blutkonzentraten Myelocyten und Plasmoblasten; in den Nierenperfusaten Myelocyten, Proplasmazellen und Plasmazellen. 3. Die Gesamtzahl kernhaltiger Zellen (einschließlich Lymphocyten und segmentkerniger Granulocyten) war in den Ausstrichpräparaten der Konzentrate aus Blut und Nierenperfusat der Schocktiere statistisch signifikant höher als in den entsprechenden Präparaten der Kontrolltiere. 4. Die Ergebnisse zeigen, daß Schockzustände mit einer vermehrten Ausschwemmung der genannten Zellen in das periphere Blut einhergehen, und tragen somit dazu bei, das Auftreten intravasaler Zellansammlungen in menschlichen Schocknieren zu erklären.
    Notes: Summary 1. Leucocyte concentrates of peripheral blood from 40 patients with shock and 20 control persons without clinical symptoms of shock were investigated for the presence of immature blood and bone marrow cells. The number of cases containing plasmoblasts, proplasmocytes, plasmocytes, promyelocytes, myelocytes, and erythroblasts, was significantly higher in the shock group. 2. Leucocyte concentrates were also investigated from the blood and from the kidney perfusion fluid of 15 rabbits with experimental hemorrhagic shock and 10 control animals. The blood concentrates of the shock group contained significantly more myelocytes and plasmoblasts, the kidney perfusates significantly more myelocytes, proplasmocytes, and plasmocytes. 3. The number of nucleated cells including lymphocytes and polymorphonuclear leucocytes was significantly higher in the smears of the leucocyte concentrates from blood and kidney perfusates within the shock group compared to the control group. 4. It may be concluded from the present results that circulatory failure is accompanied by increased delivery of immature cells into the blood. The cell accumulations in the renal blood vessels following shock may be explained by this mechanism.
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Histopathology 42 (2003), S. 0 
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Aims:  Langerhans cell histiocytosis is a rare disease with clonal proliferation of dendritic histiocytes, occurring most frequently in infancy and early childhood. In the localized form (single system), the disease is self-limiting, but in the cases of multisystem disease a third of the patients develop organ dysfunction. In these cases the prognosis is poor. Our objective has been to study the immunohistochemical expression of Fas and Fas-ligand (Fas-L) in order to determine whether the level of expression of these proteins could predict the outcome of the disease. We also wanted to determine the number of apoptotic cells to compare with the expression of Fas and Fas-L.Methods and results:  We analysed the expression of Fas and Fas-L in 76 infiltrates from 49 paediatric patients with Langerhans cell histiocytosis. We also compared the results with the expression of the tumour suppressor protein p53 and the number of cells in apoptosis detected with TUNEL. Langerhans cell histiocytosis cells showed strong expression of p53 and in some cases co-expression of Fas and Fas-L. The expression of Fas-L was significantly higher in infiltrates from patients with single-system disease. The actual number of pathological Langerhans cells in apoptosis as estimated by TUNEL was low.Conclusions:  The low number of TUNEL-reactive cells can be explained by the rapid turnover of apoptotic cells in the tissue, not leaving the apoptotic cells long enough in the tissue to be detected. The co-expression of Fas and Fas-L in some Langerhans cells can lead to an autocrine apoptotic shortcut, mediating the death of the double-positive cells. Our findings suggest that apoptosis mediated through the Fas/Fas-L pathway may contribute to the spontaneous regression of lesions in single-system disease. A delicate balance between autocrine death and survival of Langerhans cells may have been disturbed in patients with multisystem lesions.
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  • 3
    ISSN: 1437-1596
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Type of Medium: Electronic Resource
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